Publications

Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome

Authors (7)

Davor Ivankovic
James Drew
Flavie Lesept
Ian J White
Guillermo López Doménech
Sharon Tooze
Josef T Kittler

Autophagy

Published 1 March 2020

Crick labs

Sharon Tooze

Full details

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

Authors (9)

Nature Communications

Published 3 May 2019

Crick labs/ facilities

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A mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities

Authors (15)

Musharraf Jelani
Hannah C Dooley
Andrea Gubas
Hussein Sheikh Ali Mohamoud
Muhammad Tariq Masood Khan
Zahir Ali
[...]
Muhammad Ismail Khan
Jumana Yousuf Al-Aama
Asifullah Khan
Sharon Tooze
Jamal Nasir

Brain

Published 1 May 2019

Crick labs

Sharon Tooze

Full details

Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation

Authors (18)

Guang Lu
Juan Yi
Andrea Gubas
Ya-Ting Wang
Yihua Wu
Yi Ren
[...]
Shuo Deng
Dajing Xia
Ruey-Hwa Chen
Sharon Tooze
Han-Ming Shen

Autophagy

Published 1 November 2019

Crick labs

Sharon Tooze

Full details

ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIβ

Authors (6)

Journal of Cell Biology

Published 6 May 2019

Crick labs/ facilities

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Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs

Authors (12)

Åsa Birna Birgisdottir
Stephane Mouilleron
Zambarlal Bhujabal
Martina Wirth
Eva Sjøttem
Gry Evjen
[...]
Rebecca Lee
Nicola O'Reilly
Sharon Tooze
Trond Lamark
Terje Johansen

Autophagy

Published 3 August 2019

Crick labs/ facilities

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MDH1 and MPP7 regulate autophagy in pancreatic ductal adenocarcinoma

Authors (15)

Maria New
Tim Van Acker
Jun-ichi Sakamaki
Ming Jiang
Rebecca E Saunders
Jaclyn Long
[...]
Tamas Korcsmaros
Harold BJ Jefferies
Kevin M Ryan
Michael Howell
Sharon Tooze

Cancer Research

Published 15 April 2019

Crick labs/ facilities

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Autophagy pathway mapping to elucidate the function of novel autophagy regulators identified by high-throughput screening

Authors (2)

Methods in Molecular Biology

Published 5 January 2019

Crick labs

Sharon Tooze

Full details

Identification and validation of novel autophagy regulators using an endogenous readout siGENOME screen

Authors (9)

Maria New
Tim Van Acker
Ming Jiang
Rebecca Saunders
Jaclyn S Long
Jun-Ichi Sakamaki
Kevin M Ryan
Michael Howell
Sharon Tooze

Methods in Molecular Biology

Published 5 January 2019

Crick labs/ facilities

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Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

Authors (40)

Vojo Deretic
Eric Prossnitz
Mark Burge
Matthew J Campen
Judy Cannon
Ke Jian Liu
[...]
Maria Vaccaro
Tamotsu Yoshimori
Li Yu
Hong Zhang
Daniel J Klionsky

Autophagy

Published 23 June 2018

Crick labs

Sharon Tooze

Full details

A molecular perspective of mammalian autophagosome biogenesis

Authors (3)

Journal of Biological Chemistry

Published 13 April 2018

Crick labs

Sharon Tooze

Full details

mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition

Authors (12)

Claudia Manzoni
Adamantios Mamais
Sybille Dihanich
Marc PM Soutar
Helene Plun-Favreau
Rina Bandopadhyay
[...]
Paola Giunti
John Hardy
Mark Cookson
Sharon Tooze
Patrick A Lewis

Bioscience Reports

Published 20 April 2018

Crick labs

Sharon Tooze

Full details

Emerging roles of transcriptional programs in autophagy regulation

Authors (6)

Jun-Ichi Sakamaki
Jaclyn S Long
Maria New
Tim Van Acker
Sharon Tooze
Kevin M Ryan

Transcription

Published 15 March 2018

Crick labs

Sharon Tooze

Full details

SNAREing an ARP requires a LIR

Authors (1)

Sharon Tooze

Journal of Cell Biology

Published 5 March 2018

Crick labs

Sharon Tooze

Full details

SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2

Authors (8)

Kristiane Søreng
Michael J Munson
Christopher A Lamb
Gunnveig T Bjørndal
Serhiy Pankiv
Sven R Carlsson
Sharon Tooze
Anne Simonsen

EMBO Reports

Published 7 February 2018

Crick labs

Sharon Tooze

Full details

Autophagy pathway: cellular and molecular mechanisms

Authors (3)

Li Yu
Yang Chen
Sharon Tooze

Autophagy

Published 1 February 2018

Crick labs

Sharon Tooze

Full details

Control of GABARAP-mediated autophagy by the Golgi complex, centrosome and centriolar satellites

Authors (2)

Justin Joachim
Sharon Tooze

Biology of the Cell

Published 1 January 2018

Crick labs

Sharon Tooze

Full details

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Authors (28)

Benoit Bilanges
Samira Alliouachene
Wayne Pearce
Daniele Morelli
Gyorgy Szabadkai
Yuen-Li Chung
[...]
Leon O Murphy
Robert K Semple
Bernard Payrastre
Sharon Tooze
Bart Vanhaesebroeck

Nature Communications

Published 27 November 2017

Crick labs/ facilities

Full details

Centrosome to autophagosome signalling: Specific GABARAP regulation by centriolar satellites

Authors (2)

Justin Joachim
Sharon Tooze

Autophagy

Published 3 November 2017

Crick labs

Sharon Tooze

Full details

Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers

Authors (20)

Christopher J Stefan
William S Trimble
Sergio Grinstein
Guillaume Drin
Karin Reinisch
Pietro De Camilli
[...]
Alexander Van Vliet
Patrizia Agostinis
Sharon Tooze
Ayumu Sugiura
Heidi M McBride

BMC Biology

Published 31 October 2017

Crick labs

Sharon Tooze

Full details

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Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

A mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities

Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation

ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIβ

Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs

MDH1 and MPP7 regulate autophagy in pancreatic ductal adenocarcinoma

Autophagy pathway mapping to elucidate the function of novel autophagy regulators identified by high-throughput screening

Identification and validation of novel autophagy regulators using an endogenous readout siGENOME screen

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

A molecular perspective of mammalian autophagosome biogenesis

mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition

Emerging roles of transcriptional programs in autophagy regulation

SNAREing an ARP requires a LIR

SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2

Autophagy pathway: cellular and molecular mechanisms

Control of GABARAP-mediated autophagy by the Golgi complex, centrosome and centriolar satellites

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Centrosome to autophagosome signalling: Specific GABARAP regulation by centriolar satellites

Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers

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