Publications

Microtubule-associated protein 1S phosphorylation regulates dynein-driven transport in the brain and synaptogenesis in neurons

Authors (4)

Andre Teixeira Lopes
Ondine Janiv
Suzanne Claxton
Sila Ultanir

Journal of Clinical Investigation

Published 24 September 2026

Crick labs/ facilities

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The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages

Authors (10)

Rebecca Morrison
Simeon Mihaylov
Jakson Luk
Cyril Lemerle
Angela Rodgers
Natalia Athanasiadi
Huw R Morris
Enrica Pellegrino
Sila Ultanir
Maximiliano Gutierrez

Journal of Cell Science

Published 15 July 2026

Crick labs/ facilities

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Tracking gene expression of single mitochondria in live neurons using nanotweezers

Authors (12)

Annie Sahota
Binoy Paulose Nadappuram
Siân C Allerton
Flavie Lesept
Jack H Howden
Suzanne Claxton
[...]
Francesco A Aprile
Josef T Kittler
Mike Devine
Aleksandar P Ivanov
Joshua B Edel

Journal of the American Chemical Society

Published 24 June 2026

Crick labs/ facilities

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The phosphoproteomic landscape of the neurological manifestations in tuberous sclerosis complex

Authors (12)

Marie Girodengo
Simeon Mihaylov
Katarzyna Klonowska
Laura Mantoan Ritter
Helen R Flynn
Mark Skehel
[...]
Eleonora Aronica
Matthew White
David J Kwiatkowski
Sila Ultanir
Joseph M Bateman

Acta Neuropathologica

Published 20 May 2026

Crick labs/ facilities

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PRIDE entry PXD069405: Phosphoproteomics reveals altered RNA splicing as a major potential driver of pathology in the brain in tuberous sclerosis complex

Authors (2)

PRoteomics IDEntifications database (PRIDE)

Published 13 April 2026

Crick labs/ facilities

Full details

CDKL5 phosphorylates neuronal ELAVL proteins to promote mRNA binding, protein synthesis and visual cortex development

Preprint

Authors (21)

Simeon Mihaylov
Andre Teixeira Lopes
Margaux Silvestre
Gaia Bianchini
Helen R Flynn
Almaz Huseynova
[...]
Marcel Köhn
Mark Skehel
Jernej Ule
Florencia Iacaruso
Sila Ultanir

bioRxiv

Published 7 April 2026

Crick labs/ facilities

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mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node

Authors (43)

Laura Mantoan Ritter
Nicholas MP Annear
Emma L Baple
Leila Y Ben-Chaabane
Istvan Bodi
Lauren Brosson
[...]
Sila Ultanir
Bart Vanhaesebroeck
Benjamin Zare
Deb K Pal
Joseph M Bateman

Orphanet Journal of Rare Diseases

Published 27 May 2025

Crick labs

Sila Ultanir

Full details

Prenatal sodium channel dysfunction in Dravet syndrome alters cortical development

Preprint

Authors (25)

Clara Zourray
James Mills
Georgina Mills
Martina Mainardi
James Street
Joanna Bartkiewicz
[...]
Sanjay Sisodiya
Manju Kurian
Gaia Colasante
Serena Barral
Gabriele Lignani

Research Square

Published 9 May 2025

Crick labs/ facilities

Full details

Presynaptic filopodia form kinapses and modulate membrane mechanics for synchronous neurotransmission and seizure generation

Preprint

Authors (9)

Akanksha Jain
Jana Kroll
Jack F Webster
Jon Moss
Sila Ultanir
Alfredo Gonzalez-Sulser
Christian Rosenmund
Michael A Cousin
Daniela Ivanova

bioRxiv

Published 7 October 2024

Crick labs/ facilities

Full details

CDKL5’s role in microtubule-based transport and cognitive function

Preprint

Authors (4)

Andre Teixeira Lopes
Ondine Janiv
Suzanne Claxton
Sila Ultanir

bioRxiv

Published 29 August 2024

Crick labs/ facilities

Full details

Discovery and characterization of a chemical probe for cyclin-dependent kinase-like 2

Authors (14)

FM Bashore
SM Min
X Chen
S Howell
CH Rinderle
Gabriel Morel
[...]
DH Drewry
NS Pabla
Sila Ultanir
AN Bullock
AD Axtman

ACS Medicinal Chemistry Letters

Published 8 August 2024

Crick labs

Sila Ultanir

Full details

Supporting information for "Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2"

Authors (2)

Figshare

Published 3 July 2024

Crick labs

Sila Ultanir

Full details

Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders

Authors (11)

Jianzhi Jiang
Brent Wilkinson
Ilse Flores
Nicolas Hartel
Simeon Mihaylov
Veronica A Clementel
Helen R Flynn
Fowsan S Alkuraya
Sila Ultanir
Nicholas A Graham
Marcelo P Coba

Frontiers in Molecular Neuroscience

Published 4 April 2024

Crick labs/ facilities

Full details

Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain

Authors (5)

Molecular Psychiatry

Published 1 June 2024

Crick labs/ facilities

Full details

Data associated with "Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain"

Authors (5)

Figshare

Published 15 January 2024

Crick labs/ facilities

Full details

PRIDE entry PXD038505: Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

Authors (1)

Lucas Baltussen

Published 13 December 2023

Crick labs

Sila Ultanir

Full details

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

Authors (10)

Marisol Sampedro Castaneda
Lucas Baltussen
Andre Teixeira Lopes
Yichen Qiu
Liina Sirvio
Simeon Mihaylov
Suzanne Claxton
Jill C Richardson
Gabriele Lignani
Sila Ultanir

Nature Communications

Published 11 December 2023

Crick labs/ facilities

Full details

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

Authors (15)

Anna Laddach
Song Hui Chng
Reena Lasrado
Franze Progatzky
Michael Shapiro
Alek Erickson
[...]
Jens Kleinjung
Stefan Boeing
Sila Ultanir
Igor Adameyko
Vassilis Pachnis

Nature Communications

Published 22 September 2023

Crick labs/ facilities

Full details

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

Authors (16)

Simeon Mihaylov
Lydia M Castelli
Ya-Hui Lin
Aytac Gül
Nikita Soni
Christopher Hastings
[...]
Oliver Bandmann
Tatyana A Shelkovnikova
Heather Mortiboys
Sila Ultanir
Guillaume M Hautbergue

Nature Communications

Published 7 September 2023

Crick labs/ facilities

Full details

GEO entry GSE241522: A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia (bulk ATAC-seq data from ganglioid cultures)

Authors (12)

Anna Laddach
Song Hui Chng
Reena Lasrado
Franze Progatzky
Michael Shapiro
Marisol Sampedro Castaneda
[...]
Eleni Amaniti
Jens Kleinjung
Stefan Boeing
Sila Ultanir
Vassilis Pachnis

Gene Expression Omnibus (GEO)

Published 1 September 2023

Crick labs/ facilities

Full details

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Microtubule-associated protein 1S phosphorylation regulates dynein-driven transport in the brain and synaptogenesis in neurons

The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages

Tracking gene expression of single mitochondria in live neurons using nanotweezers

The phosphoproteomic landscape of the neurological manifestations in tuberous sclerosis complex

PRIDE entry PXD069405: Phosphoproteomics reveals altered RNA splicing as a major potential driver of pathology in the brain in tuberous sclerosis complex

CDKL5 phosphorylates neuronal ELAVL proteins to promote mRNA binding, protein synthesis and visual cortex development

mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node

Prenatal sodium channel dysfunction in Dravet syndrome alters cortical development

Presynaptic filopodia form kinapses and modulate membrane mechanics for synchronous neurotransmission and seizure generation

CDKL5’s role in microtubule-based transport and cognitive function

Discovery and characterization of a chemical probe for cyclin-dependent kinase-like 2

Supporting information for "Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2"

Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders

Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain

Data associated with "Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain"

PRIDE entry PXD038505: Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

GEO entry GSE241522: A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia (bulk ATAC-seq data from ganglioid cultures)

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