Publications

Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders

Authors (11)

Jianzhi Jiang
Brent Wilkinson
Ilse Flores
Nicolas Hartel
Simeon Mihaylov
Veronica A Clementel
Helen R Flynn
Fowsan S Alkuraya
Sila Ultanir
Nicholas A Graham
Marcelo P Coba

Frontiers in Molecular Neuroscience

Published 4 April 2024

Crick labs/ facilities

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Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain

Authors (5)

Molecular Psychiatry

Published 8 February 2024

Crick labs/ facilities

Full details

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

Authors (10)

Nature Communications

Published 11 December 2023

Crick labs/ facilities

Full details

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

Authors (15)

Anna Laddach
Song Hui Chng
Reena Lasrado
Franze Progatzky
Michael Shapiro
Alek Erickson
[...]
Jens Kleinjung
Stefan Boeing
Sila Ultanir
Igor Adameyko
Vassilis Pachnis

Nature Communications

Published 22 September 2023

Crick labs/ facilities

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The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

Authors (16)

Simeon Mihaylov
Lydia M Castelli
Ya-Hui Lin
Aytac Gül
Nikita Soni
Christopher Hastings
[...]
Oliver Bandmann
Tatyana A Shelkovnikova
Heather Mortiboys
Sila Ultanir
Guillaume M Hautbergue

Nature Communications

Published 7 September 2023

Crick labs/ facilities

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Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

Authors (19)

Anna Castano
Margaux Silvestre
Carrow I Wells
Jennifer L Sanderson
Carla A Ferrer
Han Wee Ong
[...]
Navlot S Pabla
Alex N Bullock
Tim A Benke
Sila Ultanir
Alison D Axtman

eLife

Published 25 July 2023

Crick labs

Sila Ultanir

Full details

Activity-dependent membrane sculpting deficits in TAOK1-linked neurodevelopmental disease

Authors (2)

Trends in Neurosciences

Published 1 August 2023

Crick labs

Sila Ultanir

Full details

Discovery of a potent and selective CDKL5/GSK3 chemical probe that is neuroprotective

Authors (16)

Han Wee Ong
Yi Liang
William Richardson
Emily R Lowry
Carrow I Wells
Xiangrong Chen
[...]
Navjot S Pabla
Sila Ultanir
Alex N Bullock
David H Drewry
Alison D Axtman

ACS Chemical Neuroscience

Published 3 May 2023

Crick labs

Sila Ultanir

Full details

Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis

Authors (9)

Pranetha Baskaran
Simeon Mihaylov
Elin Vinsland
Kriti Shah
Lucy Granat
Sila Ultanir
Andrew R Tee
Jernej Murn
Joseph M Bateman

Journal of Biological Chemistry

Published 1 January 2023

Crick labs

Sila Ultanir

Full details

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

Authors (14)

Flavia Roşianu
Simeon Mihaylov
Noreen Eder
Antonie Martiniuc
Suzanne Claxton
Helen R Flynn
[...]
Mark Skehel
Bram Snijders
Matthias Krause
Sharon Tooze
Sila Ultanir

Life Science Alliance

Published 1 February 2023

Crick labs/ facilities

Full details

Mechanistic target of rapamycin signaling in human nervous system development and disease

Authors (3)

Marie Girodengo
Sila Ultanir
Joseph M Bateman

Frontiers in Molecular Neuroscience

Published 26 September 2022

Crick labs

Sila Ultanir

Full details

Molecular profiling of enteric nervous system cell lineages

Authors (10)

Nature Protocols

Published 1 August 2022

Crick labs/ facilities

Full details

Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes

Authors (8)

Daniela Ivanova
Katharine L Dobson
Akshada Gajbhiye
Elizabeth C Davenport
Daniela Hacker
Sila Ultanir
Matthias Trost
Michael A Cousin

Science advances

Published 30 April 2021

Crick labs

Sila Ultanir

Full details

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

Authors (11)

Roman Fedoryshchak
Magdalena Přechová
Abbey M Butler
Rebecca Lee
Nicola O'Reilly
Helen R Flynn
Bram Snijders
Noreen Eder
Sila Ultanir
Stephane Mouilleron
Richard Treisman

eLife

Published 25 September 2020

Crick labs/ facilities

Full details

Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models

Authors (22)

Paolo La Montanara
Arnau Hervera
Lucas Baltussen
Thomas H Hutson
Ilaria Palmisano
Francesco De Virgiliis
[...]
Hongwei Yu
David S Millar
Nagy Istvan
Nicholas D Mazarakis
Simone Di Giovanni

Science Translational Medicine

Published 8 July 2020

Crick labs

Sila Ultanir

Full details

YAP1/TAZ drives ependymoma-like tumour formation in mice

Authors (15)

Noreen Eder
Federico Roncaroli
Marie-Charlotte Dolmart
Stuart Horswell
Felipe Andreiuolo
Helen Flynn
[...]
Jun-Hao Mao
Torsten Pietsch
Barry Thompson
Bram Snijders
Sila Ultanir

Nature Communications

Published 1 December 2020

Crick labs/ facilities

Full details

Chemical genetic identification of GAK substrates reveals its role in regulating Na+/K+-ATPase

Authors (10)

Amy W Lin
Kalbinder K Gill
Marisol Sampedro Castaneda
Irene Matucci
Noreen Eder
Suzanne Claxton
Helen Flynn
Bram Snijders
Roger George
Sila Ultanir

Life Science Alliance

Published 31 December 2018

Crick labs/ facilities

Full details

Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics

Authors (10)

Lucas Baltussen
Priscilla D Negraes
Margaux Silvestre
Suzanne Claxton
M Moeskops
Evangelos Christodoulou
Helen R Flynn
Bram Snijders
Alysson R Muotri
Sila Ultanir

EMBO Journal

Published 28 September 2018

Crick labs/ facilities

Full details

Kinases in synaptic development and neurological diseases

Authors (3)

Progress in Neuro-psychopharmacology & Biological Psychiatry

Published 8 June 2018

Crick labs

Sila Ultanir

Full details

MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development

Authors (9)

Sila Ultanir
Smita Yadav
Nicholas T Hertz
Juan A Oses-Prieto
Suzanne Claxton
Alma L Burlingame
Kevan M Shokat
Lily Y Jan
Yuh-Nung Jan

Neuron

Published 1 January 2014

Crick labs

Sila Ultanir

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Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders

Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

Activity-dependent membrane sculpting deficits in TAOK1-linked neurodevelopmental disease

Discovery of a potent and selective CDKL5/GSK3 chemical probe that is neuroprotective

Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

Mechanistic target of rapamycin signaling in human nervous system development and disease

Molecular profiling of enteric nervous system cell lineages

Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models

YAP1/TAZ drives ependymoma-like tumour formation in mice

Chemical genetic identification of GAK substrates reveals its role in regulating Na+/K+-ATPase

Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics

Kinases in synaptic development and neurological diseases

MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development

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