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Breadcrumb Simon Boulton Boulton lab DSB Repair Metabolism Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members DNA damage in mouse embryonic stem cells. Credit: Paulina Marzec. Toggle to view hero caption PublicationsYear published2023 (1)2022 (1)2020 (4)2019 (1)2014 (2) Facet Year publishedResearch topicsBiochemistry & Proteomics (7)Cell Biology (7)Cell Cycle & Chromosomes (7)Genetics & Genomics (7)Genome Integrity & Repair (7)Model Organisms (7)Chemical Biology & High Throughput (3)Computational & Systems Biology (2)Structural Biology & Biophysics (2)Tumour Biology (2)Imaging (1) Facet Research topicsPublication typeJournal article (9)Primary research (9) Facet Publication typeJournal (-)Cell Reports (9) Facet Journal Publications Displaying 1 - 9 of 9Last updated : 18 April 2024 03:39 Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways Authors (11) Joost Schimmel Núria Muñoz-Subirana Hanneke Kool Robin van Schendel Sven van der Vlies Juliette A Kamp Femke de Vrij Steven A Kushner Graeme CM SmithSimon Boulton Marcel Tijsterman Cell Reports Published 28 February 2023 Crick labsSimon BoultonFull details Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis Authors (12)Valerie BorelStefan Boeing Niek Van Wietmarschen Sriram Sridharan Bethany Rebekah Hill Luigi Ombrato[...]Deb JacksonRobert GoldstoneSimon Boulton Andre Nussenzweig Roberto Bellelli Cell Reports Published 31 May 2022 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch Authors (14) Laura C Lehmann Luka Bacic Graeme Hewitt Klaus Brackmann Anton Sabantsev Guillaume Gaullier[...] Song TanAlessandro CostaMark SkehelSimon Boulton Sebastian Deindl Cell Reports Published 22 December 2020 Crick labsAlessandro CostaSimon BoultonFull details RTEL1 regulates G4/R-loops to avert replication-transcription collisions Authors (11)Panagiotis KotsantisSandra Segura-Bayona Pol MargalefPaulina MarzecPhil Ruis Graeme HewittRoberto Bellelli Harshil PatelRobert GoldstoneAnna PoetschSimon Boulton Cell Reports Published 22 December 2020 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details Tousled-like kinases suppress innate immune signaling triggered by alternative lengthening of telomeres Authors (7)Sandra Segura-Bayona Marina Villamor-Payà Camille Stephan-Otto Attolini Lars M Koenig Maria Sanchiz-CalvoSimon Boulton Travis H Stracker Cell Reports Published 4 August 2020 Crick labs/ facilitiesSimon BoultonHigh Throughput ScreeningFull details Synthetic lethality between DNA polymerase epsilon and RTEL1 in metazoan DNA replication Authors (6)Roberto Bellelli Jillian YoudsValerie Borel Jennifer Svendsen Visnja Pavicic-KaltenbrunnerSimon Boulton Cell Reports Published 26 May 2020 Crick labs/ facilitiesSimon BoultonBiological Research FacilityFull details A meiotic checkpoint alters repair partner bias to permit inter-sister repair of persistent DSBs Authors (8) T Garcia-Muse U Galindo-Diaz M Garcia-Rubio JS Martin J PolanowskaNicola O'Reilly A AguileraSimon Boulton Cell Reports Published 15 January 2019 Crick labsSimon BoultonFull details Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex Authors (10) Zuzana Hořejší Lasse Stach Thomas G FlowerDhira Joshi Helen FlynnMark SkehelNicola O'ReillyRoksana Ogrodowicz Stephen J SmerdonSimon Boulton Cell Reports Published 18 March 2014 Crick labs/ facilitiesSteve SmerdonSimon BoultonStructural BiologyProteomicsFull details RTEL1 inhibits trinucleotide repeat expansions and fragility Authors (7) Aisling Frizzell Jennifer HG Nguyen Mark IR Petalcorin Katherine D TurnerSimon Boulton Catherine H Freudenreich Robert S Lahue Cell Reports Published 13 March 2014 Crick labsSimon BoultonFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways Authors (11) Joost Schimmel Núria Muñoz-Subirana Hanneke Kool Robin van Schendel Sven van der Vlies Juliette A Kamp Femke de Vrij Steven A Kushner Graeme CM SmithSimon Boulton Marcel Tijsterman Cell Reports Published 28 February 2023 Crick labsSimon BoultonFull details
Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis Authors (12)Valerie BorelStefan Boeing Niek Van Wietmarschen Sriram Sridharan Bethany Rebekah Hill Luigi Ombrato[...]Deb JacksonRobert GoldstoneSimon Boulton Andre Nussenzweig Roberto Bellelli Cell Reports Published 31 May 2022 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details
Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch Authors (14) Laura C Lehmann Luka Bacic Graeme Hewitt Klaus Brackmann Anton Sabantsev Guillaume Gaullier[...] Song TanAlessandro CostaMark SkehelSimon Boulton Sebastian Deindl Cell Reports Published 22 December 2020 Crick labsAlessandro CostaSimon BoultonFull details
RTEL1 regulates G4/R-loops to avert replication-transcription collisions Authors (11)Panagiotis KotsantisSandra Segura-Bayona Pol MargalefPaulina MarzecPhil Ruis Graeme HewittRoberto Bellelli Harshil PatelRobert GoldstoneAnna PoetschSimon Boulton Cell Reports Published 22 December 2020 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details
Tousled-like kinases suppress innate immune signaling triggered by alternative lengthening of telomeres Authors (7)Sandra Segura-Bayona Marina Villamor-Payà Camille Stephan-Otto Attolini Lars M Koenig Maria Sanchiz-CalvoSimon Boulton Travis H Stracker Cell Reports Published 4 August 2020 Crick labs/ facilitiesSimon BoultonHigh Throughput ScreeningFull details
Synthetic lethality between DNA polymerase epsilon and RTEL1 in metazoan DNA replication Authors (6)Roberto Bellelli Jillian YoudsValerie Borel Jennifer Svendsen Visnja Pavicic-KaltenbrunnerSimon Boulton Cell Reports Published 26 May 2020 Crick labs/ facilitiesSimon BoultonBiological Research FacilityFull details
A meiotic checkpoint alters repair partner bias to permit inter-sister repair of persistent DSBs Authors (8) T Garcia-Muse U Galindo-Diaz M Garcia-Rubio JS Martin J PolanowskaNicola O'Reilly A AguileraSimon Boulton Cell Reports Published 15 January 2019 Crick labsSimon BoultonFull details
Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex Authors (10) Zuzana Hořejší Lasse Stach Thomas G FlowerDhira Joshi Helen FlynnMark SkehelNicola O'ReillyRoksana Ogrodowicz Stephen J SmerdonSimon Boulton Cell Reports Published 18 March 2014 Crick labs/ facilitiesSteve SmerdonSimon BoultonStructural BiologyProteomicsFull details
RTEL1 inhibits trinucleotide repeat expansions and fragility Authors (7) Aisling Frizzell Jennifer HG Nguyen Mark IR Petalcorin Katherine D TurnerSimon Boulton Catherine H Freudenreich Robert S Lahue Cell Reports Published 13 March 2014 Crick labsSimon BoultonFull details