Publications

Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways

Authors (11)

Joost Schimmel
Núria Muñoz-Subirana
Hanneke Kool
Robin van Schendel
Sven van der Vlies
Juliette A Kamp
Femke de Vrij
Steven A Kushner
Graeme CM Smith
Simon Boulton
Marcel Tijsterman

Cell Reports

Published 28 February 2023

Crick labs

Simon Boulton

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Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis

Authors (12)

Valerie Borel
Stefan Boeing
Niek Van Wietmarschen
Sriram Sridharan
Bethany Rebekah Hill
Luigi Ombrato
[...]
Deb Jackson
Robert Goldstone
Simon Boulton
Andre Nussenzweig
Roberto Bellelli

Cell Reports

Published 31 May 2022

Crick labs/ facilities

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Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch

Authors (14)

Laura C Lehmann
Luka Bacic
Graeme Hewitt
Klaus Brackmann
Anton Sabantsev
Guillaume Gaullier
[...]
Song Tan
Alessandro Costa
Mark Skehel
Simon Boulton
Sebastian Deindl

Cell Reports

Published 22 December 2020

Crick labs

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RTEL1 regulates G4/R-loops to avert replication-transcription collisions

Authors (11)

Cell Reports

Published 22 December 2020

Crick labs/ facilities

Full details

Tousled-like kinases suppress innate immune signaling triggered by alternative lengthening of telomeres

Authors (7)

Sandra Segura-Bayona
Marina Villamor-Payà
Camille Stephan-Otto Attolini
Lars M Koenig
Maria Sanchiz-Calvo
Simon Boulton
Travis H Stracker

Cell Reports

Published 4 August 2020

Crick labs/ facilities

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Synthetic lethality between DNA polymerase epsilon and RTEL1 in metazoan DNA replication

Authors (6)

Roberto Bellelli
Jillian Youds
Valerie Borel
Jennifer Svendsen
Visnja Pavicic-Kaltenbrunner
Simon Boulton

Cell Reports

Published 26 May 2020

Crick labs/ facilities

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A meiotic checkpoint alters repair partner bias to permit inter-sister repair of persistent DSBs

Authors (8)

T Garcia-Muse
U Galindo-Diaz
M Garcia-Rubio
JS Martin
J Polanowska
Nicola O'Reilly
A Aguilera
Simon Boulton

Cell Reports

Published 15 January 2019

Crick labs

Simon Boulton

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Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex

Authors (10)

Zuzana Hořejší
Lasse Stach
Thomas G Flower
Dhira Joshi
Helen Flynn
Mark Skehel
Nicola O'Reilly
Roksana Ogrodowicz
Stephen J Smerdon
Simon Boulton

Cell Reports

Published 18 March 2014

Crick labs/ facilities

Full details

RTEL1 inhibits trinucleotide repeat expansions and fragility

Authors (7)

Aisling Frizzell
Jennifer HG Nguyen
Mark IR Petalcorin
Katherine D Turner
Simon Boulton
Catherine H Freudenreich
Robert S Lahue

Cell Reports

Published 13 March 2014

Crick labs

Simon Boulton

Full details

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Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways

Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis

Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch

RTEL1 regulates G4/R-loops to avert replication-transcription collisions

Tousled-like kinases suppress innate immune signaling triggered by alternative lengthening of telomeres

Synthetic lethality between DNA polymerase epsilon and RTEL1 in metazoan DNA replication

A meiotic checkpoint alters repair partner bias to permit inter-sister repair of persistent DSBs

Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex

RTEL1 inhibits trinucleotide repeat expansions and fragility

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