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Breadcrumb Simon Boulton Boulton lab DSB Repair Metabolism Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members DNA damage in mouse embryonic stem cells. Credit: Paulina Marzec. Toggle to view hero caption PublicationsYear published2023 (2)2022 (1)2021 (3)2020 (3)2019 (2)2018 (1)2017 (2)2016 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (15)Cell Biology (15)Cell Cycle & Chromosomes (15)Genetics & Genomics (15)Genome Integrity & Repair (15)Model Organisms (15)Computational & Systems Biology (10)Tumour Biology (7)Structural Biology & Biophysics (6)Human Biology & Physiology (4)Signalling & Oncogenes (4)Imaging (3)Developmental Biology (2)Gene Expression (2)Neurosciences (2)Immunology (1)Infectious Disease (1)Metabolism (1)Microfabrication & Bioengineering (1)Stem Cells (1)Synthetic Biology (1) (-)Chemical Biology & High Throughput (15) Facet Research topicsPublication typeJournal article (15)Primary research (15) Facet Publication typeJournalMolecular Cell (4)Cell Reports (3)Nature (3)Nature Communications (2)Cancer Discovery (1)Oncogene (1)Science (1) Facet Journal Publications Displaying 1 - 15 of 15Last updated : 24 April 2024 03:57 Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor Authors (10)Luke GreenhoughEric Chih-Chao LiangOndrej BelanSimone Kunzelmann Sarah MaslenMonica Rodrigo BrenniRoopesh AnandMark SkehelSimon BoultonStephen West Nature Published 20 July 2023 Crick labs/ facilitiesStephen WestSimon BoultonStructural BiologyProteomicsElectron MicroscopyFull details Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis Authors (12)Valerie BorelStefan Boeing Niek Van Wietmarschen Sriram Sridharan Bethany Rebekah Hill Luigi Ombrato[...]Deb JacksonRobert GoldstoneSimon Boulton Andre Nussenzweig Roberto Bellelli Cell Reports Published 31 May 2022 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution Authors (47)Mani VenkatesanMihaela Angelova Clare Puttick Haoran ZhaiDeborah CaswellWei-Ting Lu[...] Samuel F Bakhoum Jiri Bartek Nnennaya KanuCharles Swanton TRACERx Consortium Cancer Discovery Published 1 October 2021 Crick labs/ facilitiesCharles SwantonSimon BoultonHigh Throughput ScreeningLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesAdvanced SequencingFull details Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins Authors (12)Ondrej Belan Consuelo Barroso Artur KaczmarczykRoopesh AnandStefania FedericoNicola O'Reilly[...]Erik MaeotsRadoslav Enchev Enrique Martinez-Perez David S RuedaSimon Boulton Molecular Cell Published 4 March 2021 Crick labs/ facilitiesRadoslav EnchevSimon BoultonFermentationFull details RTEL1 regulates G4/R-loops to avert replication-transcription collisions Authors (11)Panagiotis KotsantisSandra Segura-Bayona Pol MargalefPaulina MarzecPhil Ruis Graeme HewittRoberto Bellelli Harshil PatelRobert GoldstoneAnna PoetschSimon Boulton Cell Reports Published 22 December 2020 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details TRF2-independent chromosome end protection during pluripotency Authors (13)Phil Ruis David Van LyValerie Borel Georgia R KaferAfshan Mccarthy Steven Howell[...]James BriscoeKathy NiakanPaulina Marzec Anthony J CesareSimon Boulton Nature Published 7 January 2021 Crick labs/ facilitiesKathy NiakanJames BriscoeSimon BoultonProteomicsGenetic Modification ServiceBiological Research FacilityFull details CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle Authors (12) Grzegorz SarekPanagiotis KotsantisPhil Ruis David Van Ly Pol MargalefValerie Borel[...] Helen R FlynnBram Snijders Dipanjan Chowdhury Anthony J CesareSimon Boulton Nature Published 13 November 2019 Crick labs/ facilitiesSimon BoultonProteomicsFull details A meiotic checkpoint alters repair partner bias to permit inter-sister repair of persistent DSBs Authors (8) T Garcia-Muse U Galindo-Diaz M Garcia-Rubio JS Martin J PolanowskaNicola O'Reilly A AguileraSimon Boulton Cell Reports Published 15 January 2019 Crick labsSimon BoultonFull details Polε instability drives replication stress, abnormal development, and tumorigenesis Authors (14)Roberto BellelliValerie Borel Clare Logan Jennifer Svendsen Danielle CoxEmma Nye[...] Helen R FlynnBram Snijders François Lassailly Andrew JacksonSimon Boulton Molecular Cell Published 17 May 2018 Crick labs/ facilitiesSimon BoultonProteomicsExperimental HistopathologyBiological Research FacilityFull details Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability Authors (11)Tohru Takaki Marco Montagner Murielle P Serres Maël Le BerreMatt RussellLucy Collinson Karoly SzuhaiMichael HowellSimon BoultonErik Sahai Mark Petronczki Nature Communications Published 24 July 2017 Crick labs/ facilitiesErik SahaiSimon BoultonHigh Throughput ScreeningElectron MicroscopyFull details MRE11 stability is regulated by CK2-dependent interaction with R2TP complex Authors (8) P von Morgen K Burdova TG FlowerNicola O'ReillySimon Boulton SJ Smerdon L Macurek Z Hořejší Oncogene Published 1 August 2017 Crick labs/ facilitiesSteve SmerdonSimon BoultonCell ServicesFull details Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN Authors (13) Julian StingeleRoberto Bellelli Ferdinand Alte Graeme Hewitt Grzegorz Sarek Sarah L Maslen[...]Svend Kjaer John A TainerMark Skehel Michael GrollSimon Boulton Molecular Cell Published 17 November 2016 Crick labs/ facilitiesSimon BoultonProteomicsFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor Authors (10)Luke GreenhoughEric Chih-Chao LiangOndrej BelanSimone Kunzelmann Sarah MaslenMonica Rodrigo BrenniRoopesh AnandMark SkehelSimon BoultonStephen West Nature Published 20 July 2023 Crick labs/ facilitiesStephen WestSimon BoultonStructural BiologyProteomicsElectron MicroscopyFull details
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details
Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis Authors (12)Valerie BorelStefan Boeing Niek Van Wietmarschen Sriram Sridharan Bethany Rebekah Hill Luigi Ombrato[...]Deb JacksonRobert GoldstoneSimon Boulton Andre Nussenzweig Roberto Bellelli Cell Reports Published 31 May 2022 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details
Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution Authors (47)Mani VenkatesanMihaela Angelova Clare Puttick Haoran ZhaiDeborah CaswellWei-Ting Lu[...] Samuel F Bakhoum Jiri Bartek Nnennaya KanuCharles Swanton TRACERx Consortium Cancer Discovery Published 1 October 2021 Crick labs/ facilitiesCharles SwantonSimon BoultonHigh Throughput ScreeningLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesAdvanced SequencingFull details
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details
Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins Authors (12)Ondrej Belan Consuelo Barroso Artur KaczmarczykRoopesh AnandStefania FedericoNicola O'Reilly[...]Erik MaeotsRadoslav Enchev Enrique Martinez-Perez David S RuedaSimon Boulton Molecular Cell Published 4 March 2021 Crick labs/ facilitiesRadoslav EnchevSimon BoultonFermentationFull details
RTEL1 regulates G4/R-loops to avert replication-transcription collisions Authors (11)Panagiotis KotsantisSandra Segura-Bayona Pol MargalefPaulina MarzecPhil Ruis Graeme HewittRoberto Bellelli Harshil PatelRobert GoldstoneAnna PoetschSimon Boulton Cell Reports Published 22 December 2020 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details
TRF2-independent chromosome end protection during pluripotency Authors (13)Phil Ruis David Van LyValerie Borel Georgia R KaferAfshan Mccarthy Steven Howell[...]James BriscoeKathy NiakanPaulina Marzec Anthony J CesareSimon Boulton Nature Published 7 January 2021 Crick labs/ facilitiesKathy NiakanJames BriscoeSimon BoultonProteomicsGenetic Modification ServiceBiological Research FacilityFull details
CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle Authors (12) Grzegorz SarekPanagiotis KotsantisPhil Ruis David Van Ly Pol MargalefValerie Borel[...] Helen R FlynnBram Snijders Dipanjan Chowdhury Anthony J CesareSimon Boulton Nature Published 13 November 2019 Crick labs/ facilitiesSimon BoultonProteomicsFull details
A meiotic checkpoint alters repair partner bias to permit inter-sister repair of persistent DSBs Authors (8) T Garcia-Muse U Galindo-Diaz M Garcia-Rubio JS Martin J PolanowskaNicola O'Reilly A AguileraSimon Boulton Cell Reports Published 15 January 2019 Crick labsSimon BoultonFull details
Polε instability drives replication stress, abnormal development, and tumorigenesis Authors (14)Roberto BellelliValerie Borel Clare Logan Jennifer Svendsen Danielle CoxEmma Nye[...] Helen R FlynnBram Snijders François Lassailly Andrew JacksonSimon Boulton Molecular Cell Published 17 May 2018 Crick labs/ facilitiesSimon BoultonProteomicsExperimental HistopathologyBiological Research FacilityFull details
Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability Authors (11)Tohru Takaki Marco Montagner Murielle P Serres Maël Le BerreMatt RussellLucy Collinson Karoly SzuhaiMichael HowellSimon BoultonErik Sahai Mark Petronczki Nature Communications Published 24 July 2017 Crick labs/ facilitiesErik SahaiSimon BoultonHigh Throughput ScreeningElectron MicroscopyFull details
MRE11 stability is regulated by CK2-dependent interaction with R2TP complex Authors (8) P von Morgen K Burdova TG FlowerNicola O'ReillySimon Boulton SJ Smerdon L Macurek Z Hořejší Oncogene Published 1 August 2017 Crick labs/ facilitiesSteve SmerdonSimon BoultonCell ServicesFull details
Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN Authors (13) Julian StingeleRoberto Bellelli Ferdinand Alte Graeme Hewitt Grzegorz Sarek Sarah L Maslen[...]Svend Kjaer John A TainerMark Skehel Michael GrollSimon Boulton Molecular Cell Published 17 November 2016 Crick labs/ facilitiesSimon BoultonProteomicsFull details