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Breadcrumb Simon Boulton Boulton lab DSB Repair Metabolism Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members DNA damage in mouse embryonic stem cells. Credit: Paulina Marzec. Toggle to view hero caption PublicationsYear published2021 (2)2020 (1)2018 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (4)Cell Biology (4)Cell Cycle & Chromosomes (4)Chemical Biology & High Throughput (4)Computational & Systems Biology (4)Genetics & Genomics (4)Genome Integrity & Repair (4)Model Organisms (4)Tumour Biology (3)Signalling & Oncogenes (2)Structural Biology & Biophysics (2)Developmental Biology (1)Imaging (1)Immunology (1)Infectious Disease (1)Metabolism (1) (-)Human Biology & Physiology (4) Facet Research topicsPublication typeJournal article (4)Primary research (4) Facet Publication typeJournalMolecular Cell (2)Cancer Discovery (1)Science (1) Facet Journal Publications Displaying 1 - 4 of 4Last updated : 20 April 2024 02:37 Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution Authors (47)Mani VenkatesanMihaela Angelova Clare Puttick Haoran ZhaiDeborah CaswellWei-Ting Lu[...] Samuel F Bakhoum Jiri Bartek Nnennaya KanuCharles Swanton TRACERx Consortium Cancer Discovery Published 1 October 2021 Crick labs/ facilitiesCharles SwantonSimon BoultonHigh Throughput ScreeningLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesAdvanced SequencingFull details Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details Polε instability drives replication stress, abnormal development, and tumorigenesis Authors (14)Roberto BellelliValerie Borel Clare Logan Jennifer Svendsen Danielle CoxEmma Nye[...] Helen R FlynnBram Snijders François Lassailly Andrew JacksonSimon Boulton Molecular Cell Published 17 May 2018 Crick labs/ facilitiesSimon BoultonProteomicsExperimental HistopathologyBiological Research FacilityFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution Authors (47)Mani VenkatesanMihaela Angelova Clare Puttick Haoran ZhaiDeborah CaswellWei-Ting Lu[...] Samuel F Bakhoum Jiri Bartek Nnennaya KanuCharles Swanton TRACERx Consortium Cancer Discovery Published 1 October 2021 Crick labs/ facilitiesCharles SwantonSimon BoultonHigh Throughput ScreeningLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesAdvanced SequencingFull details
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details
Polε instability drives replication stress, abnormal development, and tumorigenesis Authors (14)Roberto BellelliValerie Borel Clare Logan Jennifer Svendsen Danielle CoxEmma Nye[...] Helen R FlynnBram Snijders François Lassailly Andrew JacksonSimon Boulton Molecular Cell Published 17 May 2018 Crick labs/ facilitiesSimon BoultonProteomicsExperimental HistopathologyBiological Research FacilityFull details