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Breadcrumb Simon Boulton Boulton lab DSB Repair Metabolism Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members DNA damage in mouse embryonic stem cells. Credit: Paulina Marzec. Toggle to view hero caption PublicationsYear published2023 (2)2022 (1)2021 (3)2020 (2)2019 (1)2018 (1)2017 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (11)Cell Biology (11)Cell Cycle & Chromosomes (11)Genetics & Genomics (11)Genome Integrity & Repair (11)Model Organisms (11)Chemical Biology & High Throughput (6)Imaging (4)Computational & Systems Biology (3)Human Biology & Physiology (2)Signalling & Oncogenes (2)Tumour Biology (2)Developmental Biology (1)Immunology (1)Infectious Disease (1)Metabolism (1)Microfabrication & Bioengineering (1) (-)Structural Biology & Biophysics (11) Facet Research topicsPublication typeJournal article (11)Primary research (10)Review (1) Facet Publication typeJournalMolecular Cell (5)Cell Reports (2)Nature (1)Oncogene (1)Science (1)Trends in Cancer (1) Facet Journal Publications Displaying 1 - 11 of 11Last updated : 20 April 2024 02:13 Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein Authors (11)Ondrej BelanLuke Greenhough Lucas KuhlenRoopesh Anand Artur KaczmarczykDominika GruszkaHasan YardimciXiaodong Zhang David S RuedaStephen WestSimon Boulton Molecular Cell Published 17 August 2023 Crick labsHasan YardimciStephen WestSimon BoultonFull details Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor Authors (10)Luke GreenhoughEric Chih-Chao LiangOndrej BelanSimone Kunzelmann Sarah MaslenMonica Rodrigo BrenniRoopesh AnandMark SkehelSimon BoultonStephen West Nature Published 20 July 2023 Crick labs/ facilitiesStephen WestSimon BoultonStructural BiologyProteomicsElectron MicroscopyFull details POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells Authors (16)Ondrej BelanMarie SebaldMarek AdamowiczRoopesh AnandAleksandra Vancevska Joana Neves[...] Geoff S Higgins Graeme CM SmithStephen West David S RuedaSimon Boulton Molecular Cell Published 15 December 2022 Crick labsStephen WestSimon BoultonFull details Tackling PARP inhibitor resistance Authors (4)Kasper Fugger Graeme HewittStephen WestSimon Boulton Trends in Cancer Published 1 December 2021 Crick labsStephen WestSimon BoultonFull details Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins Authors (12)Ondrej Belan Consuelo Barroso Artur KaczmarczykRoopesh AnandStefania FedericoNicola O'Reilly[...]Erik MaeotsRadoslav Enchev Enrique Martinez-Perez David S RuedaSimon Boulton Molecular Cell Published 4 March 2021 Crick labs/ facilitiesRadoslav EnchevSimon BoultonFermentationFull details Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch Authors (14) Laura C Lehmann Luka Bacic Graeme Hewitt Klaus Brackmann Anton Sabantsev Guillaume Gaullier[...] Song TanAlessandro CostaMark SkehelSimon Boulton Sebastian Deindl Cell Reports Published 22 December 2020 Crick labsAlessandro CostaSimon BoultonFull details Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details A meiotic checkpoint alters repair partner bias to permit inter-sister repair of persistent DSBs Authors (8) T Garcia-Muse U Galindo-Diaz M Garcia-Rubio JS Martin J PolanowskaNicola O'Reilly A AguileraSimon Boulton Cell Reports Published 15 January 2019 Crick labsSimon BoultonFull details POLE3-POLE4 is a histone H3-H4 chaperone that maintains chromatin integrity during DNA replication Authors (9)Roberto BellelliOndrej BelanVal Pye Camille Clement Sarah L MaslenMark SkehelPeter Cherepanov Genevieve AlmouzniSimon Boulton Molecular Cell Published 4 October 2018 Crick labs/ facilitiesPeter Cherepanov Simon BoultonFlow CytometryFull details MRE11 stability is regulated by CK2-dependent interaction with R2TP complex Authors (8) P von Morgen K Burdova TG FlowerNicola O'ReillySimon Boulton SJ Smerdon L Macurek Z Hořejší Oncogene Published 1 August 2017 Crick labs/ facilitiesSteve SmerdonSimon BoultonCell ServicesFull details Share the page Share on Twitter Share 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Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein Authors (11)Ondrej BelanLuke Greenhough Lucas KuhlenRoopesh Anand Artur KaczmarczykDominika GruszkaHasan YardimciXiaodong Zhang David S RuedaStephen WestSimon Boulton Molecular Cell Published 17 August 2023 Crick labsHasan YardimciStephen WestSimon BoultonFull details
Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor Authors (10)Luke GreenhoughEric Chih-Chao LiangOndrej BelanSimone Kunzelmann Sarah MaslenMonica Rodrigo BrenniRoopesh AnandMark SkehelSimon BoultonStephen West Nature Published 20 July 2023 Crick labs/ facilitiesStephen WestSimon BoultonStructural BiologyProteomicsElectron MicroscopyFull details
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells Authors (16)Ondrej BelanMarie SebaldMarek AdamowiczRoopesh AnandAleksandra Vancevska Joana Neves[...] Geoff S Higgins Graeme CM SmithStephen West David S RuedaSimon Boulton Molecular Cell Published 15 December 2022 Crick labsStephen WestSimon BoultonFull details
Tackling PARP inhibitor resistance Authors (4)Kasper Fugger Graeme HewittStephen WestSimon Boulton Trends in Cancer Published 1 December 2021 Crick labsStephen WestSimon BoultonFull details
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details
Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins Authors (12)Ondrej Belan Consuelo Barroso Artur KaczmarczykRoopesh AnandStefania FedericoNicola O'Reilly[...]Erik MaeotsRadoslav Enchev Enrique Martinez-Perez David S RuedaSimon Boulton Molecular Cell Published 4 March 2021 Crick labs/ facilitiesRadoslav EnchevSimon BoultonFermentationFull details
Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch Authors (14) Laura C Lehmann Luka Bacic Graeme Hewitt Klaus Brackmann Anton Sabantsev Guillaume Gaullier[...] Song TanAlessandro CostaMark SkehelSimon Boulton Sebastian Deindl Cell Reports Published 22 December 2020 Crick labsAlessandro CostaSimon BoultonFull details
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details
A meiotic checkpoint alters repair partner bias to permit inter-sister repair of persistent DSBs Authors (8) T Garcia-Muse U Galindo-Diaz M Garcia-Rubio JS Martin J PolanowskaNicola O'Reilly A AguileraSimon Boulton Cell Reports Published 15 January 2019 Crick labsSimon BoultonFull details
POLE3-POLE4 is a histone H3-H4 chaperone that maintains chromatin integrity during DNA replication Authors (9)Roberto BellelliOndrej BelanVal Pye Camille Clement Sarah L MaslenMark SkehelPeter Cherepanov Genevieve AlmouzniSimon Boulton Molecular Cell Published 4 October 2018 Crick labs/ facilitiesPeter Cherepanov Simon BoultonFlow CytometryFull details
MRE11 stability is regulated by CK2-dependent interaction with R2TP complex Authors (8) P von Morgen K Burdova TG FlowerNicola O'ReillySimon Boulton SJ Smerdon L Macurek Z Hořejší Oncogene Published 1 August 2017 Crick labs/ facilitiesSteve SmerdonSimon BoultonCell ServicesFull details