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Breadcrumb Simon Boulton Boulton lab DSB Repair Metabolism Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members DNA damage in mouse embryonic stem cells. Credit: Paulina Marzec. Toggle to view hero caption PublicationsYear published2023 (1)2022 (1)2021 (2)2020 (2)2018 (1)2017 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (8)Cell Biology (8)Cell Cycle & Chromosomes (8)Genetics & Genomics (8)Genome Integrity & Repair (8)Model Organisms (8)Chemical Biology & High Throughput (7)Computational & Systems Biology (7)Human Biology & Physiology (3)Gene Expression (2)Imaging (2)Signalling & Oncogenes (2)Structural Biology & Biophysics (2)Developmental Biology (1)Immunology (1)Infectious Disease (1)Metabolism (1)Neurosciences (1)Stem Cells (1) (-)Tumour Biology (8) Facet Research topicsPublication typeJournal article (8)Primary research (8) Facet Publication typeJournalCell Reports (2)Nature Communications (2)Cancer Discovery (1)Genome Biology (1)Molecular Cell (1)Science (1) Facet Journal Publications Displaying 1 - 8 of 8Last updated : 18 April 2024 03:21 Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis Authors (12)Valerie BorelStefan Boeing Niek Van Wietmarschen Sriram Sridharan Bethany Rebekah Hill Luigi Ombrato[...]Deb JacksonRobert GoldstoneSimon Boulton Andre Nussenzweig Roberto Bellelli Cell Reports Published 31 May 2022 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution Authors (47)Mani VenkatesanMihaela Angelova Clare Puttick Haoran ZhaiDeborah CaswellWei-Ting Lu[...] Samuel F Bakhoum Jiri Bartek Nnennaya KanuCharles Swanton TRACERx Consortium Cancer Discovery Published 1 October 2021 Crick labs/ facilitiesCharles SwantonSimon BoultonHigh Throughput ScreeningLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesAdvanced SequencingFull details Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details RTEL1 regulates G4/R-loops to avert replication-transcription collisions Authors (11)Panagiotis KotsantisSandra Segura-Bayona Pol MargalefPaulina MarzecPhil Ruis Graeme HewittRoberto Bellelli Harshil PatelRobert GoldstoneAnna PoetschSimon Boulton Cell Reports Published 22 December 2020 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis Authors (3)Anna PoetschSimon BoultonNicholas Luscombe Genome Biology Published 7 December 2018 Crick labs/ facilitiesNicholas LuscombeSimon BoultonBioinformatics and BiostatisticsFull details Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability Authors (11)Tohru Takaki Marco Montagner Murielle P Serres Maël Le BerreMatt RussellLucy Collinson Karoly SzuhaiMichael HowellSimon BoultonErik Sahai Mark Petronczki Nature Communications Published 24 July 2017 Crick labs/ facilitiesErik SahaiSimon BoultonHigh Throughput ScreeningElectron MicroscopyFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details
Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis Authors (12)Valerie BorelStefan Boeing Niek Van Wietmarschen Sriram Sridharan Bethany Rebekah Hill Luigi Ombrato[...]Deb JacksonRobert GoldstoneSimon Boulton Andre Nussenzweig Roberto Bellelli Cell Reports Published 31 May 2022 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details
Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution Authors (47)Mani VenkatesanMihaela Angelova Clare Puttick Haoran ZhaiDeborah CaswellWei-Ting Lu[...] Samuel F Bakhoum Jiri Bartek Nnennaya KanuCharles Swanton TRACERx Consortium Cancer Discovery Published 1 October 2021 Crick labs/ facilitiesCharles SwantonSimon BoultonHigh Throughput ScreeningLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesAdvanced SequencingFull details
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details
RTEL1 regulates G4/R-loops to avert replication-transcription collisions Authors (11)Panagiotis KotsantisSandra Segura-Bayona Pol MargalefPaulina MarzecPhil Ruis Graeme HewittRoberto Bellelli Harshil PatelRobert GoldstoneAnna PoetschSimon Boulton Cell Reports Published 22 December 2020 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details
Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis Authors (3)Anna PoetschSimon BoultonNicholas Luscombe Genome Biology Published 7 December 2018 Crick labs/ facilitiesNicholas LuscombeSimon BoultonBioinformatics and BiostatisticsFull details
Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability Authors (11)Tohru Takaki Marco Montagner Murielle P Serres Maël Le BerreMatt RussellLucy Collinson Karoly SzuhaiMichael HowellSimon BoultonErik Sahai Mark Petronczki Nature Communications Published 24 July 2017 Crick labs/ facilitiesErik SahaiSimon BoultonHigh Throughput ScreeningElectron MicroscopyFull details