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Breadcrumb Simon Boulton Boulton lab DSB Repair Metabolism Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members DNA damage in mouse embryonic stem cells. Credit: Paulina Marzec. Toggle to view hero caption PublicationsYear published (-)2020 (10) Facet Year publishedResearch topicsBiochemistry & Proteomics (10)Cell Biology (10)Cell Cycle & Chromosomes (10)Genetics & Genomics (10)Genome Integrity & Repair (10)Model Organisms (10)Chemical Biology & High Throughput (3)Computational & Systems Biology (3)Structural Biology & Biophysics (2)Tumour Biology (2)Developmental Biology (1)Gene Expression (1)Human Biology & Physiology (1)Imaging (1)Neurosciences (1)Signalling & Oncogenes (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (10)Primary research (8)Review (2) Facet Publication typeJournalCell Reports (4)Genes and Development (1)Molecular Cell (1)Nature (1)Nucleic Acids Research (1)The EMBO Journal (1)Trends in Genetics (1) Facet Journal Publications Displaying 1 - 10 of 10Last updated : 23 April 2024 02:04 The end protection problem-an unexpected twist in the tail Authors (2)Phil RuisSimon Boulton Genes and Development Published 1 January 2021 Crick labsSimon BoultonFull details Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch Authors (14) Laura C Lehmann Luka Bacic Graeme Hewitt Klaus Brackmann Anton Sabantsev Guillaume Gaullier[...] Song TanAlessandro CostaMark SkehelSimon Boulton Sebastian Deindl Cell Reports Published 22 December 2020 Crick labsAlessandro CostaSimon BoultonFull details RTEL1 regulates G4/R-loops to avert replication-transcription collisions Authors (11)Panagiotis KotsantisSandra Segura-Bayona Pol MargalefPaulina MarzecPhil Ruis Graeme HewittRoberto Bellelli Harshil PatelRobert GoldstoneAnna PoetschSimon Boulton Cell Reports Published 22 December 2020 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates Authors (14) Chaoyou Xue Lucia Molnarova Justin B Steinfeld Weixing Zhao Chujian Ma Mario Spirek[...] Katerina KrejciSimon Boulton Patrick Sung Eric C Greene Lumir Krejci Nucleic Acids Research Published 11 January 2021 Crick labsSimon BoultonFull details Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details TRF2-independent chromosome end protection during pluripotency Authors (13)Phil Ruis David Van LyValerie Borel Georgia R KaferAfshan Mccarthy Steven Howell[...]James BriscoeKathy NiakanPaulina Marzec Anthony J CesareSimon Boulton Nature Published 7 January 2021 Crick labs/ facilitiesKathy NiakanJames BriscoeSimon BoultonProteomicsGenetic Modification ServiceBiological Research FacilityFull details Spotlight on the replisome: Aetiology of DNA replication-associated genetic diseases Authors (2) Roberto BellelliSimon Boulton Trends in Genetics Published 1 April 2021 Crick labsSimon BoultonFull details Tousled-like kinases suppress innate immune signaling triggered by alternative lengthening of telomeres Authors (7)Sandra Segura-Bayona Marina Villamor-Payà Camille Stephan-Otto Attolini Lars M Koenig Maria Sanchiz-CalvoSimon Boulton Travis H Stracker Cell Reports Published 4 August 2020 Crick labs/ facilitiesSimon BoultonHigh Throughput ScreeningFull details Synthetic lethality between DNA polymerase epsilon and RTEL1 in metazoan DNA replication Authors (6)Roberto Bellelli Jillian YoudsValerie Borel Jennifer Svendsen Visnja Pavicic-KaltenbrunnerSimon Boulton Cell Reports Published 26 May 2020 Crick labs/ facilitiesSimon BoultonBiological Research FacilityFull details SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres Authors (6) Aleksandra Vančevska Wareed Ahmed Verena Pfeiffer Marianna FeretzakiSimon Boulton Joachim Lingner The EMBO Journal Published 21 February 2020 Crick labsSimon BoultonFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The end protection problem-an unexpected twist in the tail Authors (2)Phil RuisSimon Boulton Genes and Development Published 1 January 2021 Crick labsSimon BoultonFull details
Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch Authors (14) Laura C Lehmann Luka Bacic Graeme Hewitt Klaus Brackmann Anton Sabantsev Guillaume Gaullier[...] Song TanAlessandro CostaMark SkehelSimon Boulton Sebastian Deindl Cell Reports Published 22 December 2020 Crick labsAlessandro CostaSimon BoultonFull details
RTEL1 regulates G4/R-loops to avert replication-transcription collisions Authors (11)Panagiotis KotsantisSandra Segura-Bayona Pol MargalefPaulina MarzecPhil Ruis Graeme HewittRoberto Bellelli Harshil PatelRobert GoldstoneAnna PoetschSimon Boulton Cell Reports Published 22 December 2020 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details
Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates Authors (14) Chaoyou Xue Lucia Molnarova Justin B Steinfeld Weixing Zhao Chujian Ma Mario Spirek[...] Katerina KrejciSimon Boulton Patrick Sung Eric C Greene Lumir Krejci Nucleic Acids Research Published 11 January 2021 Crick labsSimon BoultonFull details
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details
TRF2-independent chromosome end protection during pluripotency Authors (13)Phil Ruis David Van LyValerie Borel Georgia R KaferAfshan Mccarthy Steven Howell[...]James BriscoeKathy NiakanPaulina Marzec Anthony J CesareSimon Boulton Nature Published 7 January 2021 Crick labs/ facilitiesKathy NiakanJames BriscoeSimon BoultonProteomicsGenetic Modification ServiceBiological Research FacilityFull details
Spotlight on the replisome: Aetiology of DNA replication-associated genetic diseases Authors (2) Roberto BellelliSimon Boulton Trends in Genetics Published 1 April 2021 Crick labsSimon BoultonFull details
Tousled-like kinases suppress innate immune signaling triggered by alternative lengthening of telomeres Authors (7)Sandra Segura-Bayona Marina Villamor-Payà Camille Stephan-Otto Attolini Lars M Koenig Maria Sanchiz-CalvoSimon Boulton Travis H Stracker Cell Reports Published 4 August 2020 Crick labs/ facilitiesSimon BoultonHigh Throughput ScreeningFull details
Synthetic lethality between DNA polymerase epsilon and RTEL1 in metazoan DNA replication Authors (6)Roberto Bellelli Jillian YoudsValerie Borel Jennifer Svendsen Visnja Pavicic-KaltenbrunnerSimon Boulton Cell Reports Published 26 May 2020 Crick labs/ facilitiesSimon BoultonBiological Research FacilityFull details
SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres Authors (6) Aleksandra Vančevska Wareed Ahmed Verena Pfeiffer Marianna FeretzakiSimon Boulton Joachim Lingner The EMBO Journal Published 21 February 2020 Crick labsSimon BoultonFull details