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Boulton lab
DSB Repair Metabolism Laboratory
: Publications

Publications

Displaying 1 - 7 of 7

Last updated : 16 April 2024 02:59

POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells

Authors (16)

Ondrej Belan
Marie Sebald
Marek Adamowicz
Roopesh Anand
Aleksandra Vancevska
Joana Neves
[...]
Geoff S Higgins
Graeme CM Smith
Stephen West
David S Rueda
Simon Boulton

Published 15 December 2022

Crick labs

Search and processing of Holliday junctions within long DNA by junction-resolving enzymes

Authors (6)

Artur P Kaczmarczyk
Anne-Cécile Déclais
Matt Newton
Simon Boulton
David MJ Lilley
David S Rueda

Nature Communications

Published 7 October 2022

Crick labs

Simon Boulton

Discovery, characterization, and structure-based optimization of small-molecule in vitro and in vivo probes for human DNA polymerase theta

Authors (33)

Martin L Stockley
Amanda Ferdinand
Giovanni Benedetti
Peter Blencowe
Susan M Boyd
Mat Calder
[...]
Graeme CM Smith
Martin E Swarbrick
Andrew P Turnbull
Simon Willis
Robert A Heald

Journal of Medicinal Chemistry

Published 27 October 2022

Crick labs

Simon Boulton

Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells

Authors (13)

Clara Novo
Emily V Wong
Colin Hockings
Chetan Poudel
Eleanor Sheekey
Meike Wiese
[...]
Srinjan Basu
Simon Walker
Gabriele S Kaminski Schierle
Geeta J Narlikar
Peter J Rugg-Gunn

Nature Communications

Published 20 June 2022

Crick labs

Simon Boulton

Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis

Authors (12)

Valerie Borel
Stefan Boeing
Niek Van Wietmarschen
Sriram Sridharan
Bethany Rebekah Hill
Luigi Ombrato
[...]
Deb Jackson
Robert Goldstone
Simon Boulton
Andre Nussenzweig
Roberto Bellelli

Published 31 May 2022

Crick labs/ facilities

H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

Authors (14)

Rachel Bayley
Valerie Borel
Rhiannon J Moss
Ellie Sweatman
Phil Ruis
Alice Ormrod
[...]
Graeme Hewitt
Marco Saponaro
Grant S Stewart
Simon Boulton
Martin R Higgs

Published 19 May 2022

Crick labs/ facilities

Proline-specific aminopeptidase P prevents replication-associated genome instability

Authors (10)

Nicola Silva
Maikel Castellano-Pozo
Kenichiro Matsuzaki
Consuelo Barroso
Monica Roman-Trufero
Hannah Craig
Darren R Brooks
R Elwyn Isaac
Simon Boulton
Enrique Martinez-Perez

Published 26 January 2022

Crick labs

Simon Boulton