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Breadcrumb Simon Boulton Boulton lab DSB Repair Metabolism Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members DNA damage in mouse embryonic stem cells. Credit: Paulina Marzec. Toggle to view hero caption PublicationsYear published (-)2023 (9) Facet Year publishedResearch topicsBiochemistry & Proteomics (9)Cell Biology (9)Cell Cycle & Chromosomes (9)Genetics & Genomics (9)Genome Integrity & Repair (9)Model Organisms (9)Chemical Biology & High Throughput (2)Computational & Systems Biology (2)Structural Biology & Biophysics (2)Gene Expression (1)Imaging (1)Neurosciences (1)Stem Cells (1)Tumour Biology (1) Facet Research topicsPublication typeJournal article (9)Primary research (8)Commentary (1) Facet Publication typeJournalMolecular Cell (3)Cell Reports (1)Clinical cancer research (1)Nature (1)Nature Communications (1)Nature Genetics (1)Nucleic Acids Research (1) Facet Journal Publications Displaying 1 - 9 of 9Last updated : 19 April 2024 02:44 Extraordinary collateral mutagenesis induced by CX-5461 Authors (1)Simon Boulton Nature Genetics Published 1 January 2024 Crick labsSimon BoultonFull details Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells Authors (12) Eeson Rajendra Diego Grande Bethany Mason Daniela Di Marcantonio Lucy Armstrong Graeme Hewitt[...] Alessandro GalbiatiSimon Boulton Robert A Heald Graeme CM Smith Helen MR Robinson Nucleic Acids Research Published 28 February 2024 Crick labsSimon BoultonFull details Negative DNA supercoiling induces genome-wide Cas9 off-target activity Authors (13)Matt Newton Marialucrezia Losito Quentin M SmithVenkata Nishita Mohan Parnandi Benjamin J Taylor Pinar Akcakaya[...] Simon H ReedSimon Boulton Graeme A King Maria Emanuela Cuomo David S Rueda Molecular Cell Published 5 October 2023 Crick labsSimon BoultonFull details Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein Authors (11)Ondrej BelanLuke Greenhough Lucas KuhlenRoopesh Anand Artur KaczmarczykDominika GruszkaHasan YardimciXiaodong Zhang David S RuedaStephen WestSimon Boulton Molecular Cell Published 17 August 2023 Crick labsHasan YardimciStephen WestSimon BoultonFull details Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor Authors (10)Luke GreenhoughEric Chih-Chao LiangOndrej BelanSimone Kunzelmann Sarah MaslenMonica Rodrigo BrenniRoopesh AnandMark SkehelSimon BoultonStephen West Nature Published 20 July 2023 Crick labs/ facilitiesStephen WestSimon BoultonStructural BiologyProteomicsElectron MicroscopyFull details Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining Authors (18) Hubert Fleury Myles K MacEachern Clara M StiefelRoopesh Anand Colin Sempeck Benjamin Nebenfuehr[...] Laila Weatherly Djelika Dansoko Justin W LeungSimon Boulton Nausica Arnoult Molecular Cell Published 4 May 2023 Crick labsSimon BoultonFull details Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways Authors (11) Joost Schimmel Núria Muñoz-Subirana Hanneke Kool Robin van Schendel Sven van der Vlies Juliette A Kamp Femke de Vrij Steven A Kushner Graeme CM SmithSimon Boulton Marcel Tijsterman Cell Reports Published 28 February 2023 Crick labsSimon BoultonFull details Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models Authors (24) Gonzalo Rodriguez-Berriguete Marco Ranzani Remko Prevo Rathi Puliyadi Nicole Machado Hannah R Bolland[...] Ester M Hammond Robert A Heald Graeme CM Smith Helen MR Robinson Geoff S Higgins Clinical cancer research Published 15 April 2023 Crick labsSimon BoultonFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Extraordinary collateral mutagenesis induced by CX-5461 Authors (1)Simon Boulton Nature Genetics Published 1 January 2024 Crick labsSimon BoultonFull details
Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells Authors (12) Eeson Rajendra Diego Grande Bethany Mason Daniela Di Marcantonio Lucy Armstrong Graeme Hewitt[...] Alessandro GalbiatiSimon Boulton Robert A Heald Graeme CM Smith Helen MR Robinson Nucleic Acids Research Published 28 February 2024 Crick labsSimon BoultonFull details
Negative DNA supercoiling induces genome-wide Cas9 off-target activity Authors (13)Matt Newton Marialucrezia Losito Quentin M SmithVenkata Nishita Mohan Parnandi Benjamin J Taylor Pinar Akcakaya[...] Simon H ReedSimon Boulton Graeme A King Maria Emanuela Cuomo David S Rueda Molecular Cell Published 5 October 2023 Crick labsSimon BoultonFull details
Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein Authors (11)Ondrej BelanLuke Greenhough Lucas KuhlenRoopesh Anand Artur KaczmarczykDominika GruszkaHasan YardimciXiaodong Zhang David S RuedaStephen WestSimon Boulton Molecular Cell Published 17 August 2023 Crick labsHasan YardimciStephen WestSimon BoultonFull details
Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor Authors (10)Luke GreenhoughEric Chih-Chao LiangOndrej BelanSimone Kunzelmann Sarah MaslenMonica Rodrigo BrenniRoopesh AnandMark SkehelSimon BoultonStephen West Nature Published 20 July 2023 Crick labs/ facilitiesStephen WestSimon BoultonStructural BiologyProteomicsElectron MicroscopyFull details
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details
The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining Authors (18) Hubert Fleury Myles K MacEachern Clara M StiefelRoopesh Anand Colin Sempeck Benjamin Nebenfuehr[...] Laila Weatherly Djelika Dansoko Justin W LeungSimon Boulton Nausica Arnoult Molecular Cell Published 4 May 2023 Crick labsSimon BoultonFull details
Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways Authors (11) Joost Schimmel Núria Muñoz-Subirana Hanneke Kool Robin van Schendel Sven van der Vlies Juliette A Kamp Femke de Vrij Steven A Kushner Graeme CM SmithSimon Boulton Marcel Tijsterman Cell Reports Published 28 February 2023 Crick labsSimon BoultonFull details
Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models Authors (24) Gonzalo Rodriguez-Berriguete Marco Ranzani Remko Prevo Rathi Puliyadi Nicole Machado Hannah R Bolland[...] Ester M Hammond Robert A Heald Graeme CM Smith Helen MR Robinson Geoff S Higgins Clinical cancer research Published 15 April 2023 Crick labsSimon BoultonFull details