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Breadcrumb Simon Boulton Boulton lab DSB Repair Metabolism Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members DNA damage in mouse embryonic stem cells. Credit: Paulina Marzec. Toggle to view hero caption PublicationsYear published2023 (9)2022 (7)2021 (14)2020 (10)2019 (6)2018 (8)2017 (9)2016 (2)2015 (8)2014 (7)2013 (7)2012 (6)2011 (2)2010 (8) Facet Year publishedResearch topicsBiochemistry & Proteomics (70)Cell Biology (70)Cell Cycle & Chromosomes (70)Genetics & Genomics (70)Genome Integrity & Repair (70)Model Organisms (70)Chemical Biology & High Throughput (15)Computational & Systems Biology (11)Structural Biology & Biophysics (11)Tumour Biology (8)Imaging (7)Human Biology & Physiology (4)Signalling & Oncogenes (4)Gene Expression (3)Developmental Biology (2)Neurosciences (2)Immunology (1)Infectious Disease (1)Metabolism (1)Microfabrication & Bioengineering (1)Stem Cells (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (103)Primary research (78)Review (19)Commentary (2)Editorial (2)Method (2) Facet Publication typeJournalMolecular Cell (24)Cell Reports (9)Nature (9)Nature Communications (7)Science (5)Journal of Cell Science (4)Cell (3)Nucleic Acids Research (3)PLOS Genetics (3)Cancer Discovery (2)DNA Repair (2)Genes & Development (2)Genes and Development (2)Nature Reviews Molecular Cell Biology (2)STAR Protocols (2)Trends in Cell Biology (2)American Journal of Human Genetics (1)Cell Cycle (1)Chromosoma (1)Clinical cancer research (1)Current Opinion in Genetics and Development (1)eLife (1)EMBO Journal (1)EMBO Reports (1)FEBS Letters (1)Frontiers in Cell and Developmental Biology (1)Frontiers in Immunology (1)Genome Biology (1)Journal of Biological Chemistry (1)Journal of Clinical Oncology (1)Journal of Medicinal Chemistry (1)Nature Genetics (1)Nature Structural & Molecular Biology (1)Oncogene (1)PLOS ONE (1)The EMBO Journal (1)Trends in Cancer (1)Trends in Genetics (1) Facet Journal Publications Displaying 21 - 40 of 103Last updated : 17 April 2024 03:36 A tale of two states: pluripotency regulation of telomeres Authors (1)Clara Novo Frontiers in Cell and Developmental Biology Published 8 July 2021 Crick labsSimon BoultonFull details Mechanism of mitotic recombination: insights from C. elegans Authors (3)Ondrej BelanRoopesh AnandSimon Boulton Current Opinion in Genetics and Development Published 1 December 2021 Crick labsSimon BoultonFull details Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance Authors (61) Diana Zatreanu Helen MR Robinson Omar Alkhatib Marie Boursier Harry Finch Lerin Geo[...]Simon Boulton Geoff S Higgins Stephen J Pettitt Graeme CM Smith Christopher J Lord Nature Communications Published 17 June 2021 Crick labsSimon BoultonFull details Generation of versatile ss-dsDNA hybrid substrates for single-molecule analysis Authors (7)Ondrej Belan George Moore Artur KaczmarczykMatt NewtonRoopesh AnandSimon Boulton David S Rueda STAR Protocols Published 18 June 2021 Crick labsSimon BoultonFull details A C-circle assay for detection of alternative lengthening of telomere activity in FFPE tissue Authors (4)Aurora IdilliSandra Segura-Bayona Timothy P LippertSimon Boulton STAR Protocols Published 18 June 2021 Crick labs/ facilitiesSimon BoultonExperimental HistopathologyFull details Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution Authors (47)Mani VenkatesanMihaela Angelova Clare Puttick Haoran ZhaiDeborah CaswellWei-Ting Lu[...] Samuel F Bakhoum Jiri Bartek Nnennaya KanuCharles Swanton TRACERx Consortium Cancer Discovery Published 1 October 2021 Crick labs/ facilitiesCharles SwantonSimon BoultonHigh Throughput ScreeningLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesAdvanced SequencingFull details Protection of the C. elegans germ cell genome depends on diverse DNA repair pathways during normal proliferation Authors (10) Bettina Meier Nadezda V Volkova Ye Hong Simone Bertolini Víctor González-Huici Tsvetana PetrovaSimon Boulton Peter J Campbell Moritz Gerstung Anton Gartner PLOS ONE Published 27 April 2021 Crick labsSimon BoultonFull details Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres Authors (10) Timothy P LippertPaulina MarzecAurora Idilli Grzegorz SarekAleksandra Vancevska Mark Bower Paul J Farrell Päivi M Ojala Niklas FeldhahnSimon Boulton Nature Communications Published 21 January 2021 Crick labs/ facilitiesSimon BoultonExperimental HistopathologyFull details Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins Authors (12)Ondrej Belan Consuelo Barroso Artur KaczmarczykRoopesh AnandStefania FedericoNicola O'Reilly[...]Erik MaeotsRadoslav Enchev Enrique Martinez-Perez David S RuedaSimon Boulton Molecular Cell Published 4 March 2021 Crick labs/ facilitiesRadoslav EnchevSimon BoultonFermentationFull details The end protection problem-an unexpected twist in the tail Authors (2)Phil RuisSimon Boulton Genes and Development Published 1 January 2021 Crick labsSimon BoultonFull details Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch Authors (14) Laura C Lehmann Luka Bacic Graeme Hewitt Klaus Brackmann Anton Sabantsev Guillaume Gaullier[...] Song TanAlessandro CostaMark SkehelSimon Boulton Sebastian Deindl Cell Reports Published 22 December 2020 Crick labsAlessandro CostaSimon BoultonFull details RTEL1 regulates G4/R-loops to avert replication-transcription collisions Authors (11)Panagiotis KotsantisSandra Segura-Bayona Pol MargalefPaulina MarzecPhil Ruis Graeme HewittRoberto Bellelli Harshil PatelRobert GoldstoneAnna PoetschSimon Boulton Cell Reports Published 22 December 2020 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates Authors (14) Chaoyou Xue Lucia Molnarova Justin B Steinfeld Weixing Zhao Chujian Ma Mario Spirek[...] Katerina KrejciSimon Boulton Patrick Sung Eric C Greene Lumir Krejci Nucleic Acids Research Published 11 January 2021 Crick labsSimon BoultonFull details Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details TRF2-independent chromosome end protection during pluripotency Authors (13)Phil Ruis David Van LyValerie Borel Georgia R KaferAfshan Mccarthy Steven Howell[...]James BriscoeKathy NiakanPaulina Marzec Anthony J CesareSimon Boulton Nature Published 7 January 2021 Crick labs/ facilitiesKathy NiakanJames BriscoeSimon BoultonProteomicsGenetic Modification ServiceBiological Research FacilityFull details Spotlight on the replisome: Aetiology of DNA replication-associated genetic diseases Authors (2) Roberto BellelliSimon Boulton Trends in Genetics Published 1 April 2021 Crick labsSimon BoultonFull details Tousled-like kinases suppress innate immune signaling triggered by alternative lengthening of telomeres Authors (7)Sandra Segura-Bayona Marina Villamor-Payà Camille Stephan-Otto Attolini Lars M Koenig Maria Sanchiz-CalvoSimon Boulton Travis H Stracker Cell Reports Published 4 August 2020 Crick labs/ facilitiesSimon BoultonHigh Throughput ScreeningFull details Synthetic lethality between DNA polymerase epsilon and RTEL1 in metazoan DNA replication Authors (6)Roberto Bellelli Jillian YoudsValerie Borel Jennifer Svendsen Visnja Pavicic-KaltenbrunnerSimon Boulton Cell Reports Published 26 May 2020 Crick labs/ facilitiesSimon BoultonBiological Research FacilityFull details SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres Authors (6) Aleksandra Vančevska Wareed Ahmed Verena Pfeiffer Marianna FeretzakiSimon Boulton Joachim Lingner The EMBO Journal Published 21 February 2020 Crick labsSimon BoultonFull details Pagination First page First Previous page Previous Page 1 Current page 2 Page 3 Page 4 Page 5 Page 6 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
A tale of two states: pluripotency regulation of telomeres Authors (1)Clara Novo Frontiers in Cell and Developmental Biology Published 8 July 2021 Crick labsSimon BoultonFull details
Mechanism of mitotic recombination: insights from C. elegans Authors (3)Ondrej BelanRoopesh AnandSimon Boulton Current Opinion in Genetics and Development Published 1 December 2021 Crick labsSimon BoultonFull details
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance Authors (61) Diana Zatreanu Helen MR Robinson Omar Alkhatib Marie Boursier Harry Finch Lerin Geo[...]Simon Boulton Geoff S Higgins Stephen J Pettitt Graeme CM Smith Christopher J Lord Nature Communications Published 17 June 2021 Crick labsSimon BoultonFull details
Generation of versatile ss-dsDNA hybrid substrates for single-molecule analysis Authors (7)Ondrej Belan George Moore Artur KaczmarczykMatt NewtonRoopesh AnandSimon Boulton David S Rueda STAR Protocols Published 18 June 2021 Crick labsSimon BoultonFull details
A C-circle assay for detection of alternative lengthening of telomere activity in FFPE tissue Authors (4)Aurora IdilliSandra Segura-Bayona Timothy P LippertSimon Boulton STAR Protocols Published 18 June 2021 Crick labs/ facilitiesSimon BoultonExperimental HistopathologyFull details
Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution Authors (47)Mani VenkatesanMihaela Angelova Clare Puttick Haoran ZhaiDeborah CaswellWei-Ting Lu[...] Samuel F Bakhoum Jiri Bartek Nnennaya KanuCharles Swanton TRACERx Consortium Cancer Discovery Published 1 October 2021 Crick labs/ facilitiesCharles SwantonSimon BoultonHigh Throughput ScreeningLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesAdvanced SequencingFull details
Protection of the C. elegans germ cell genome depends on diverse DNA repair pathways during normal proliferation Authors (10) Bettina Meier Nadezda V Volkova Ye Hong Simone Bertolini Víctor González-Huici Tsvetana PetrovaSimon Boulton Peter J Campbell Moritz Gerstung Anton Gartner PLOS ONE Published 27 April 2021 Crick labsSimon BoultonFull details
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details
Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres Authors (10) Timothy P LippertPaulina MarzecAurora Idilli Grzegorz SarekAleksandra Vancevska Mark Bower Paul J Farrell Päivi M Ojala Niklas FeldhahnSimon Boulton Nature Communications Published 21 January 2021 Crick labs/ facilitiesSimon BoultonExperimental HistopathologyFull details
Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins Authors (12)Ondrej Belan Consuelo Barroso Artur KaczmarczykRoopesh AnandStefania FedericoNicola O'Reilly[...]Erik MaeotsRadoslav Enchev Enrique Martinez-Perez David S RuedaSimon Boulton Molecular Cell Published 4 March 2021 Crick labs/ facilitiesRadoslav EnchevSimon BoultonFermentationFull details
The end protection problem-an unexpected twist in the tail Authors (2)Phil RuisSimon Boulton Genes and Development Published 1 January 2021 Crick labsSimon BoultonFull details
Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch Authors (14) Laura C Lehmann Luka Bacic Graeme Hewitt Klaus Brackmann Anton Sabantsev Guillaume Gaullier[...] Song TanAlessandro CostaMark SkehelSimon Boulton Sebastian Deindl Cell Reports Published 22 December 2020 Crick labsAlessandro CostaSimon BoultonFull details
RTEL1 regulates G4/R-loops to avert replication-transcription collisions Authors (11)Panagiotis KotsantisSandra Segura-Bayona Pol MargalefPaulina MarzecPhil Ruis Graeme HewittRoberto Bellelli Harshil PatelRobert GoldstoneAnna PoetschSimon Boulton Cell Reports Published 22 December 2020 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details
Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates Authors (14) Chaoyou Xue Lucia Molnarova Justin B Steinfeld Weixing Zhao Chujian Ma Mario Spirek[...] Katerina KrejciSimon Boulton Patrick Sung Eric C Greene Lumir Krejci Nucleic Acids Research Published 11 January 2021 Crick labsSimon BoultonFull details
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details
TRF2-independent chromosome end protection during pluripotency Authors (13)Phil Ruis David Van LyValerie Borel Georgia R KaferAfshan Mccarthy Steven Howell[...]James BriscoeKathy NiakanPaulina Marzec Anthony J CesareSimon Boulton Nature Published 7 January 2021 Crick labs/ facilitiesKathy NiakanJames BriscoeSimon BoultonProteomicsGenetic Modification ServiceBiological Research FacilityFull details
Spotlight on the replisome: Aetiology of DNA replication-associated genetic diseases Authors (2) Roberto BellelliSimon Boulton Trends in Genetics Published 1 April 2021 Crick labsSimon BoultonFull details
Tousled-like kinases suppress innate immune signaling triggered by alternative lengthening of telomeres Authors (7)Sandra Segura-Bayona Marina Villamor-Payà Camille Stephan-Otto Attolini Lars M Koenig Maria Sanchiz-CalvoSimon Boulton Travis H Stracker Cell Reports Published 4 August 2020 Crick labs/ facilitiesSimon BoultonHigh Throughput ScreeningFull details
Synthetic lethality between DNA polymerase epsilon and RTEL1 in metazoan DNA replication Authors (6)Roberto Bellelli Jillian YoudsValerie Borel Jennifer Svendsen Visnja Pavicic-KaltenbrunnerSimon Boulton Cell Reports Published 26 May 2020 Crick labs/ facilitiesSimon BoultonBiological Research FacilityFull details
SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres Authors (6) Aleksandra Vančevska Wareed Ahmed Verena Pfeiffer Marianna FeretzakiSimon Boulton Joachim Lingner The EMBO Journal Published 21 February 2020 Crick labsSimon BoultonFull details