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Breadcrumb Sonia Gandhi Gandhi lab Neurodegeneration Biology Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Publications Members Dopaminergic neurons generated from human induced pluripotent stem cells. Blue stain for the nuclei and yellow stain for tyrosine hydroxylase, a dopaminergic neuron marker. Toggle to view hero caption PublicationsYear published2024 (2)2023 (5)2022 (11)2021 (10)2020 (6)2019 (2)2018 (2)2017 (1) Facet Year publishedResearch topicsCell Biology (39)Neurosciences (39)Computational & Systems Biology (23)Genetics & Genomics (23)Tumour Biology (23)Chemical Biology & High Throughput (22)Genome Integrity & Repair (22)Human Biology & Physiology (21)Immunology (20)Infectious Disease (20)Model Organisms (19)Signalling & Oncogenes (18)Cell Cycle & Chromosomes (17)Metabolism (17)Structural Biology & Biophysics (17)Biochemistry & Proteomics (10)Developmental Biology (7)Imaging (7)Gene Expression (4)Synthetic Biology (2)Microfabrication & Bioengineering (1) (-)Stem Cells (39) Facet Research topicsPublication typeJournal article (39) (-)Primary research (39) Facet Publication typeJournalThe Lancet (6)Nature Cancer (3)Acta Neuropathologica (1)Acta Neuropathologica Communications (1)Brain (1)Cancer Cell (1)Cell Death & Disease (1)Cell Death and Differentiation (1)Cell Reports (1)Cell Reports Medicine (1)Clinical Infectious Diseases (1)Communications Biology (1)eLife (1)Epilepsy and Behavior (1)Lancet (1)Movement Disorders (1)Movement Disorders Clinical Practice (1)Nature Aging (1)Nature Chemistry (1)Nature Communications (1)Nature Machine Intelligence (1)Nature Medicine (1)Nature Neuroscience (1)npj Parkinsons Disease (1)Nucleic Acids Research (1)PLOS Biology (1)PLOS ONE (1)Science (1)Science advances (1)Science Translational Medicine (1)Scientific Reports (1)Stem Cell Research (1) Facet Journal Publications Displaying 1 - 20 of 39Last updated : 29 March 2024 02:49 COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates Authors (19) Rebecca S Saleeb Craig Leighton Ji-Eun Lee Judi O'Shaughnessy Kiani Jeacock Alexandre Chappard[...] Rachel AngersSonia Gandhi Patrick Downey Tilo Kunath Mathew H Horrocks Science advances Published 17 November 2023 Crick labsSonia GandhiFull details Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models Authors (13) Karishma D'saJames EvansGurvir Virdi Giulia Vecchi Alexander Adam Ottavia Bertolli[...] Craig Leighton Mathew H HorrocksDilan AthaudaMinee ChoiSonia Gandhi Nature Machine Intelligence Published 1 August 2023 Crick labs/ facilitiesSonia GandhiHigh Throughput ScreeningFull details Commercial immunoglobulin products contain neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 spike protein Authors (29) Vinit Upasani Katie TownsendMary WuEdward Carr Agnieszka Hobbs Giulia Dowgier[...]Rupert BealeSonia Gandhi Emma C Wall Laura McCoy David M Lowe Clinical Infectious Diseases Published 1 October 2023 Crick labsSonia GandhiRupert BealeFull details Generation of TWO G51D SNCA missense mutation iPSC lines (CRICKi011-A, CRICKi012-A) from two individuals at risk of Parkinson’s disease Authors (7)Liani Gasparini Devito Zeinab Shadman ZanjaniJames Evans Annarita Scardamaglia Henry HouldenSonia GandhiLyn Healy Stem Cell Research Published 1 September 2023 Crick labs/ facilitiesSonia GandhiHuman Embryonic Stem CellCell ServicesAdvanced SequencingFull details Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons Authors (26)Gurvir VirdiMinee ChoiJames EvansZhi YaoDilan Athauda Stephanie Strohbuecker[...] Tilo Kunath Mathew H Horrocks Andrey Y AbramovRickie PataniSonia Gandhi npj Parkinsons Disease Published 24 November 2022 Crick labs/ facilitiesRickie PataniSonia GandhiBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyFlow CytometryFull details Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's Authors (20) Christina E Toomey Wendy E HeywoodJames Evans Joanne Lachica Sarah N Pressey Sandrine C Foti[...] Tammaryn Lashley Steve M Gentleman Tamas Revesz Kevin MillsSonia Gandhi Acta Neuropathologica Communications Published 8 September 2022 Crick labsSonia GandhiFull details Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci Authors (29) Marc PM Soutar Daniela Melandri Benjamin O'Callaghan Emily Annuario Amy E Monaghan Natalie J Welsh[...] Alexander J Whitworth Claudia Manzoni Mina Ryten Patrick A Lewis Hélène Plun-Favreau Brain Published 1 December 2022 Crick labsSonia GandhiFull details Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity Authors (30)Minee Choi Alexandre Chappard Bhanu P SinghCatherine Maclachlan Margarida Rodrigues Evgeniya I Fedotova[...]Lucy Collinson David Klenerman Andrey Y Abramov Mathew H HorrocksSonia Gandhi Nature Neuroscience Published 1 September 2022 Crick labs/ facilitiesSonia GandhiElectron MicroscopyFull details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details Structure-specific amyloid precipitation in biofluids Authors (20) M Rodrigues P Bhattacharjee A Brinkmalm DT Do CM Pearson S De[...] H Zetterberg TN SnaddonSonia Gandhi SF Lee D Klenerman Nature Chemistry Published 1 September 2022 Crick labsSonia GandhiFull details The impact of type 2 diabetes in Parkinson's disease Authors (14)Dilan AthaudaJames Evans Anna WernickGurvir VirdiMinee Choi Michael Lawton[...] Khalida Ismail Huw Morris Donald Grosset Thomas FoltynieSonia Gandhi Movement Disorders Published 1 August 2022 Crick labsSonia GandhiFull details Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19)Edward CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C WallEdward Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details
Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates Authors (19) Rebecca S Saleeb Craig Leighton Ji-Eun Lee Judi O'Shaughnessy Kiani Jeacock Alexandre Chappard[...] Rachel AngersSonia Gandhi Patrick Downey Tilo Kunath Mathew H Horrocks Science advances Published 17 November 2023 Crick labsSonia GandhiFull details
Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models Authors (13) Karishma D'saJames EvansGurvir Virdi Giulia Vecchi Alexander Adam Ottavia Bertolli[...] Craig Leighton Mathew H HorrocksDilan AthaudaMinee ChoiSonia Gandhi Nature Machine Intelligence Published 1 August 2023 Crick labs/ facilitiesSonia GandhiHigh Throughput ScreeningFull details
Commercial immunoglobulin products contain neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 spike protein Authors (29) Vinit Upasani Katie TownsendMary WuEdward Carr Agnieszka Hobbs Giulia Dowgier[...]Rupert BealeSonia Gandhi Emma C Wall Laura McCoy David M Lowe Clinical Infectious Diseases Published 1 October 2023 Crick labsSonia GandhiRupert BealeFull details
Generation of TWO G51D SNCA missense mutation iPSC lines (CRICKi011-A, CRICKi012-A) from two individuals at risk of Parkinson’s disease Authors (7)Liani Gasparini Devito Zeinab Shadman ZanjaniJames Evans Annarita Scardamaglia Henry HouldenSonia GandhiLyn Healy Stem Cell Research Published 1 September 2023 Crick labs/ facilitiesSonia GandhiHuman Embryonic Stem CellCell ServicesAdvanced SequencingFull details
Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons Authors (26)Gurvir VirdiMinee ChoiJames EvansZhi YaoDilan Athauda Stephanie Strohbuecker[...] Tilo Kunath Mathew H Horrocks Andrey Y AbramovRickie PataniSonia Gandhi npj Parkinsons Disease Published 24 November 2022 Crick labs/ facilitiesRickie PataniSonia GandhiBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyFlow CytometryFull details
Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's Authors (20) Christina E Toomey Wendy E HeywoodJames Evans Joanne Lachica Sarah N Pressey Sandrine C Foti[...] Tammaryn Lashley Steve M Gentleman Tamas Revesz Kevin MillsSonia Gandhi Acta Neuropathologica Communications Published 8 September 2022 Crick labsSonia GandhiFull details
Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci Authors (29) Marc PM Soutar Daniela Melandri Benjamin O'Callaghan Emily Annuario Amy E Monaghan Natalie J Welsh[...] Alexander J Whitworth Claudia Manzoni Mina Ryten Patrick A Lewis Hélène Plun-Favreau Brain Published 1 December 2022 Crick labsSonia GandhiFull details
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity Authors (30)Minee Choi Alexandre Chappard Bhanu P SinghCatherine Maclachlan Margarida Rodrigues Evgeniya I Fedotova[...]Lucy Collinson David Klenerman Andrey Y Abramov Mathew H HorrocksSonia Gandhi Nature Neuroscience Published 1 September 2022 Crick labs/ facilitiesSonia GandhiElectron MicroscopyFull details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
Structure-specific amyloid precipitation in biofluids Authors (20) M Rodrigues P Bhattacharjee A Brinkmalm DT Do CM Pearson S De[...] H Zetterberg TN SnaddonSonia Gandhi SF Lee D Klenerman Nature Chemistry Published 1 September 2022 Crick labsSonia GandhiFull details
The impact of type 2 diabetes in Parkinson's disease Authors (14)Dilan AthaudaJames Evans Anna WernickGurvir VirdiMinee Choi Michael Lawton[...] Khalida Ismail Huw Morris Donald Grosset Thomas FoltynieSonia Gandhi Movement Disorders Published 1 August 2022 Crick labsSonia GandhiFull details
Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19)Edward CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C WallEdward Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details