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Breadcrumb Stephen West West lab DNA Recombination and Repair Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Lab news Alumni Cell unable to complete the recombinational repair process shows abnormalities at cell division. Toggle to view hero caption PublicationsYear published2023 (2)2022 (1)2021 (1)2020 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (5)Cell Biology (5)Cell Cycle & Chromosomes (5)Chemical Biology & High Throughput (5)Genetics & Genomics (5)Genome Integrity & Repair (5)Structural Biology & Biophysics (5)Model Organisms (4)Tumour Biology (4)Human Biology & Physiology (3)Developmental Biology (2)Immunology (2)Infectious Disease (2)Metabolism (2)Signalling & Oncogenes (2)Imaging (1) (-)Computational & Systems Biology (5) Facet Research topicsPublication typeJournal article (5)Primary research (5) Facet Publication typeJournalMolecular Cell (1)Nature (1)Nature Communications (1)Proceedings of the National Academy of Sciences of USA (1)Science (1) Facet Journal Publications Displaying 1 - 5 of 5Last updated : 25 April 2024 03:27 Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1 Authors (8)Neil RzechorzekSimone Kunzelmann Andrew G PurkissMariana Silva Dos SantosJames MacraeIan TaylorKasper FuggerStephen West Nature Communications Published 26 October 2023 Crick labs/ facilitiesStephen WestIan TaylorStructural BiologyMetabolomicsFull details Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor Authors (10)Luke GreenhoughEric Chih-Chao LiangOndrej BelanSimone Kunzelmann Sarah MaslenMonica Rodrigo BrenniRoopesh AnandMark SkehelSimon BoultonStephen West Nature Published 20 July 2023 Crick labs/ facilitiesStephen WestSimon BoultonStructural BiologyProteomicsElectron MicroscopyFull details Integrated genome and transcriptome analyses reveal the mechanism of genome instability in ataxia with oculomotor apraxia 2 Authors (13) Radhakrishnan Kanagaraj Richard Mitter Theodoros Kantidakis Matthew M EdwardsAnaid Benitez Probir Chakravarty[...] Fengtang Yang Martin F Lavin Amnon KorenAengus StewartStephen West Proceedings of the National Academy of Sciences of USA Published 25 January 2022 Crick labs/ facilitiesStephen WestBioinformatics and BiostatisticsFlow CytometryCell ServicesAdvanced SequencingFull details Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1 Authors (8)Neil RzechorzekSimone Kunzelmann Andrew G PurkissMariana Silva Dos SantosJames MacraeIan TaylorKasper FuggerStephen West Nature Communications Published 26 October 2023 Crick labs/ facilitiesStephen WestIan TaylorStructural BiologyMetabolomicsFull details
Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor Authors (10)Luke GreenhoughEric Chih-Chao LiangOndrej BelanSimone Kunzelmann Sarah MaslenMonica Rodrigo BrenniRoopesh AnandMark SkehelSimon BoultonStephen West Nature Published 20 July 2023 Crick labs/ facilitiesStephen WestSimon BoultonStructural BiologyProteomicsElectron MicroscopyFull details
Integrated genome and transcriptome analyses reveal the mechanism of genome instability in ataxia with oculomotor apraxia 2 Authors (13) Radhakrishnan Kanagaraj Richard Mitter Theodoros Kantidakis Matthew M EdwardsAnaid Benitez Probir Chakravarty[...] Fengtang Yang Martin F Lavin Amnon KorenAengus StewartStephen West Proceedings of the National Academy of Sciences of USA Published 25 January 2022 Crick labs/ facilitiesStephen WestBioinformatics and BiostatisticsFlow CytometryCell ServicesAdvanced SequencingFull details
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Authors (27) Graeme HewittValerie BorelSandra Segura-BayonaTohru TakakiPhil RuisRoberto Bellelli[...] Ivan Ahel Dragana Ahel J Ross Chapman Sebastian DeindlSimon Boulton Molecular Cell Published 18 February 2021 Crick labs/ facilitiesStephen WestSimon BoultonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingGenetic Modification ServiceBiological Research FacilityFull details