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Breadcrumb Stephen West West lab DNA Recombination and Repair Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Lab news Alumni Cell unable to complete the recombinational repair process shows abnormalities at cell division. Toggle to view hero caption PublicationsYear published2023 (1)2021 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (2)Cell Biology (2)Cell Cycle & Chromosomes (2)Chemical Biology & High Throughput (2)Computational & Systems Biology (2)Genetics & Genomics (2)Genome Integrity & Repair (2)Human Biology & Physiology (2)Immunology (2)Infectious Disease (2)Metabolism (2)Model Organisms (2)Signalling & Oncogenes (2)Structural Biology & Biophysics (2)Tumour Biology (2)Imaging (1) (-)Developmental Biology (2) Facet Research topicsPublication typeJournal article (2)Primary research (2) Facet Publication typeJournalNature Communications (1)Science (1) Facet Journal Publications Displaying 1 - 2 of 2Last updated : 29 March 2024 03:28 Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1 Authors (8)Neil RzechorzekSimone Kunzelmann Andrew G PurkissMariana Silva Dos SantosJames MacraeIan TaylorKasper FuggerStephen West Nature Communications Published 26 October 2023 Crick labs/ facilitiesStephen WestIan TaylorStructural BiologyMetabolomicsFull details Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1 Authors (8)Neil RzechorzekSimone Kunzelmann Andrew G PurkissMariana Silva Dos SantosJames MacraeIan TaylorKasper FuggerStephen West Nature Communications Published 26 October 2023 Crick labs/ facilitiesStephen WestIan TaylorStructural BiologyMetabolomicsFull details
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details