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Breadcrumb Steve Gamblin Gamblin lab Structural Biology of Disease Processes Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Structures of proteins investigated in the Gamblin lab: AMPK, PRC2 and influenza hemagglutinin (left to right). Toggle to view hero caption PublicationsYear published2023 (11)2022 (10)2021 (13)2020 (12)2019 (4)2018 (4)2017 (2)2016 (6)2015 (3)2014 (5)2013 (5)2012 (4)2011 (5)2010 (3) Facet Year publishedResearch topicsCell Cycle & Chromosomes (64)Infectious Disease (64)Metabolism (64)Structural Biology & Biophysics (64)Chemical Biology & High Throughput (46)Model Organisms (35)Cell Biology (34)Computational & Systems Biology (28)Genetics & Genomics (28)Genome Integrity & Repair (26)Immunology (26)Human Biology & Physiology (25)Tumour Biology (24)Stem Cells (23)Neurosciences (22)Signalling & Oncogenes (22)Imaging (17)Biochemistry & Proteomics (16)Developmental Biology (10)Synthetic Biology (4)Gene Expression (3)Microfabrication & Bioengineering (2) Facet Research topicsPublication typeJournal article (87)Primary research (66)Review (8)Letter (5)Commentary (3)Method (3)Case report (1)Obituary (1) Facet Publication typeJournalThe Lancet (9)Nature (7)Nature Communications (7)Proceedings of the National Academy of Sciences of the United States of America (4)Journal of Virology (3)Nature Cancer (3)Science (3)Biochemical Journal (2)Cancer Cell (2)Cell (2)Current Opinion in Structural Biology (2)Methods in Molecular Biology (2)PLOS Pathogens (2)Proceedings of the National Academy of Sciences of USA (2)Structure (2)Virology (2)ACS Central Science (1)Cell Host and Microbe (1)Cell Metabolism (1)Cell Reports (1)Cell Reports Medicine (1)Cold Spring Harbor Perspectives in Medicine (1)eLife (1)Emerging Microbes & Infections (1)Europace (1)Frontiers in Immunology (1)Journal of Biological Chemistry (1)Journal of Infectious Diseases (1)Journal of Medicinal Chemistry (1)Journal of Molecular Biology (1)Lancet (1)Lancet Infectious Diseases (1)Med (1)Microbiology Today (1)Molecular Cell (1)Nature Aging (1)Nature Biotechnology (1)Nature Chemical Biology (1)Nature Genetics (1)Nature Structural & Molecular Biology (1)Nature Structural and Molecular Biology (1)Nucleic Acids Research (1)PLOS Biology (1)RSC Advances: an international journal to further the chemical sciences (1)Science advances (1)Science Translational Medicine (1)Seminars in Immunology (1)Trends in Biochemical Sciences (1)Virus Research (1) Facet Journal Publications Displaying 1 - 20 of 87Last updated : 01 December 2023 02:10 TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry Authors (25) Jim Baggen Maarten Jacquemyn Leentje Persoons Els VanstreelsVal PyeAntoni Wrobel[...] Alusha Andre Mamchak Maxime Ah Young-Chapon Eric BrownPeter Cherepanov Dirk Daelemans Cell Published 3 August 2023 Crick labs/ facilitiesSteve GamblinPeter Cherepanov Structural BiologyFull details Evolutionarily conserved amino acids in MHC-II mediate bat influenza A virus entry into human cells Authors (11) Okikiola M Olajide Maria Kaukab Osman Jonathan Robert Susanne Kessler Lina Kathrin Toews Thiprampai Thamamongood Jacques NeefjesAntoni Wrobel Martin Schwemmle Kevin Ciminski Peter Reuther PLOS Biology Published 6 July 2023 Crick labsSteve GamblinFull details Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection Authors (36) Edward J CarrMary Wu Joshua Gahir Ruth Harvey Hermaleigh Townsley Chris Bailey[...]Charles SwantonSonia GandhiDavid LV Bauer Emma C Wall Crick COVID Serology Consortium Lancet Infectious Diseases Published 1 July 2023 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingScientific computingFull details Development of high affinity broadly reactive aptamers for spike protein of multiple SARS-CoV-2 variants Authors (4) Thao T LeDonald BentonAntoni WrobelSteve Gamblin RSC Advances: an international journal to further the chemical sciences Published 19 May 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike Authors (1)Antoni Wrobel Current Opinion in Structural Biology Published 1 August 2023 Crick labsSteve GamblinFull details Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer Authors (67)Mary WuScott Shepherd Annika Fendler Edward J CarrLewis Au Ruth Harvey[...] Emma Nicholson James Larkin Emma C WallSamra Turajlic CAPTURE consortium Cancer Cell Published 8 May 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient Authors (24) Lena Jaki Sebastian Weigang Lisa Kern Stefanie KrammeAntoni Wrobel Andrea B Grawitz[...] Thomas Welte Georg Kochs Daniela Huzly Marcus Panning Jonas Fuchs Nature Communications Published 10 April 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein Authors (13) Valeria CalvaresiAntoni Wrobel Joanna Toporowska Dietmar Hammerschmid Katie J Doores Richard T Bradshaw[...]Chloe Roustan Eamonn Reading Michael H MalimSteve Gamblin Argyris Politis Nature Communications Published 14 March 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern Authors (22)Edgar Gonzalez-RodriguezMia Zol-HanlonGanka Bineva-ToddAndrea MarchesiMark Skehel Keira E Mahoney[...]Robert Wilkinson Emma C Wall Ramón Hurtado-Guerrero Stacy A MalakerBen Schumann ACS Central Science Published 22 March 2023 Crick labs/ facilitiesRobert J WilkinsonBen SchumannSteve GamblinStructural BiologyProteomicsChemical BiologyFull details Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details Hold your horses: The receptor-binding domains of SARS-CoV-2, SARS-CoV, and hCoV-NL63 bind equine ACE2 Authors (2) Philipp NawrathAntoni Wrobel Structure Published 6 October 2022 Crick labsSteve GamblinFull details WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed Authors (19)Mary Wu Edward J Carr Ruth HarveyHarriet MearsSvend Kjaer Hermaleigh Townsley[...] Bryan WilliamsSonia GandhiCharles Swanton Emma C WallDavid LV Bauer The Lancet Published 17 December 2022 Crick labs/ facilitiesCharles SwantonNicola LewisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH Authors (7)Eva Garcia MoroJie ZhangLesley CalderNick R BrownSteve GamblinJohn J SkehelPeter Rosenthal Proceedings of the National Academy of Sciences of USA Published 16 August 2022 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary WuRuth HarveySaira Hussain[...]Michael HowellHisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details Determination of histone methyltransferase structure by crystallography Authors (1)Jon Wilson Methods in Molecular Biology Published 23 June 2022 Crick labsSteve GamblinFull details Evolution of the SARS-CoV-2 spike protein in thehuman host Authors (9)Antoni WrobelDonald BentonChloe RoustanAnnabel BorgSaira HussainStephen R MartinPeter RosenthalJohn J SkehelSteve Gamblin Nature Communications Published 4 March 2022 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinDavid LV BauerStructural BiologyScientific computingFull details Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19) Edward J CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry Authors (25) Jim Baggen Maarten Jacquemyn Leentje Persoons Els VanstreelsVal PyeAntoni Wrobel[...] Alusha Andre Mamchak Maxime Ah Young-Chapon Eric BrownPeter Cherepanov Dirk Daelemans Cell Published 3 August 2023 Crick labs/ facilitiesSteve GamblinPeter Cherepanov Structural BiologyFull details
Evolutionarily conserved amino acids in MHC-II mediate bat influenza A virus entry into human cells Authors (11) Okikiola M Olajide Maria Kaukab Osman Jonathan Robert Susanne Kessler Lina Kathrin Toews Thiprampai Thamamongood Jacques NeefjesAntoni Wrobel Martin Schwemmle Kevin Ciminski Peter Reuther PLOS Biology Published 6 July 2023 Crick labsSteve GamblinFull details
Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details
Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection Authors (36) Edward J CarrMary Wu Joshua Gahir Ruth Harvey Hermaleigh Townsley Chris Bailey[...]Charles SwantonSonia GandhiDavid LV Bauer Emma C Wall Crick COVID Serology Consortium Lancet Infectious Diseases Published 1 July 2023 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingScientific computingFull details
Development of high affinity broadly reactive aptamers for spike protein of multiple SARS-CoV-2 variants Authors (4) Thao T LeDonald BentonAntoni WrobelSteve Gamblin RSC Advances: an international journal to further the chemical sciences Published 19 May 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike Authors (1)Antoni Wrobel Current Opinion in Structural Biology Published 1 August 2023 Crick labsSteve GamblinFull details
Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer Authors (67)Mary WuScott Shepherd Annika Fendler Edward J CarrLewis Au Ruth Harvey[...] Emma Nicholson James Larkin Emma C WallSamra Turajlic CAPTURE consortium Cancer Cell Published 8 May 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient Authors (24) Lena Jaki Sebastian Weigang Lisa Kern Stefanie KrammeAntoni Wrobel Andrea B Grawitz[...] Thomas Welte Georg Kochs Daniela Huzly Marcus Panning Jonas Fuchs Nature Communications Published 10 April 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein Authors (13) Valeria CalvaresiAntoni Wrobel Joanna Toporowska Dietmar Hammerschmid Katie J Doores Richard T Bradshaw[...]Chloe Roustan Eamonn Reading Michael H MalimSteve Gamblin Argyris Politis Nature Communications Published 14 March 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern Authors (22)Edgar Gonzalez-RodriguezMia Zol-HanlonGanka Bineva-ToddAndrea MarchesiMark Skehel Keira E Mahoney[...]Robert Wilkinson Emma C Wall Ramón Hurtado-Guerrero Stacy A MalakerBen Schumann ACS Central Science Published 22 March 2023 Crick labs/ facilitiesRobert J WilkinsonBen SchumannSteve GamblinStructural BiologyProteomicsChemical BiologyFull details
Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details
Hold your horses: The receptor-binding domains of SARS-CoV-2, SARS-CoV, and hCoV-NL63 bind equine ACE2 Authors (2) Philipp NawrathAntoni Wrobel Structure Published 6 October 2022 Crick labsSteve GamblinFull details
WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed Authors (19)Mary Wu Edward J Carr Ruth HarveyHarriet MearsSvend Kjaer Hermaleigh Townsley[...] Bryan WilliamsSonia GandhiCharles Swanton Emma C WallDavid LV Bauer The Lancet Published 17 December 2022 Crick labs/ facilitiesCharles SwantonNicola LewisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details
Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details
Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH Authors (7)Eva Garcia MoroJie ZhangLesley CalderNick R BrownSteve GamblinJohn J SkehelPeter Rosenthal Proceedings of the National Academy of Sciences of USA Published 16 August 2022 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary WuRuth HarveySaira Hussain[...]Michael HowellHisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
Determination of histone methyltransferase structure by crystallography Authors (1)Jon Wilson Methods in Molecular Biology Published 23 June 2022 Crick labsSteve GamblinFull details
Evolution of the SARS-CoV-2 spike protein in thehuman host Authors (9)Antoni WrobelDonald BentonChloe RoustanAnnabel BorgSaira HussainStephen R MartinPeter RosenthalJohn J SkehelSteve Gamblin Nature Communications Published 4 March 2022 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinDavid LV BauerStructural BiologyScientific computingFull details
Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19) Edward J CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details