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Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Breadcrumb Steve Gamblin Gamblin lab Structural Biology of Disease Processes Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Structures of proteins investigated in the Gamblin lab: AMPK, PRC2 and influenza hemagglutinin (left to right). 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the chemical sciences (1)Science advances (1)Science Translational Medicine (1)Seminars in Immunology (1)Trends in Biochemical Sciences (1)Virus Research (1) Facet Journal Publications Displaying 1 - 20 of 83Last updated : 09 June 2023 02:23 Development of high affinity broadly reactive aptamers for spike protein of multiple SARS-CoV-2 variants Authors (4) Thao T LeDonald BentonAntoni WrobelSteve Gamblin RSC Advances: an international journal to further the chemical sciences Published 19 May 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike Authors (1)Antoni Wrobel Current Opinion in Structural Biology Published 1 August 2023 Crick labsSteve GamblinFull details Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer Authors (67)Mary WuScott Shepherd Annika Fendler Edward J CarrLewis Au Ruth Harvey[...] Emma Nicholson James Larkin Emma C WallSamra Turajlic CAPTURE consortium Cancer Cell Published 8 May 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient Authors (24) Lena Jaki Sebastian Weigang Lisa Kern Stefanie KrammeAntoni Wrobel Andrea B Grawitz[...] Thomas Welte Georg Kochs Daniela Huzly Marcus Panning Jonas Fuchs Nature Communications Published 10 April 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein Authors (13) Valeria CalvaresiAntoni Wrobel Joanna Toporowska Dietmar Hammerschmid Katie J Doores Richard T Bradshaw[...]Chloe Roustan Eamonn Reading Michael H MalimSteve Gamblin Argyris Politis Nature Communications Published 14 March 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern Authors (22)Edgar Gonzalez-RodriguezMia Zol-HanlonGanka Bineva-ToddAndrea MarchesiMark Skehel Keira E Mahoney[...]Robert Wilkinson Emma C Wall Ramón Hurtado-Guerrero Stacy A MalakerBen Schumann ACS Central Science Published 22 March 2023 Crick labs/ facilitiesRobert J WilkinsonBen SchumannSteve GamblinStructural BiologyProteomicsChemical BiologyFull details Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details Hold your horses: The receptor-binding domains of SARS-CoV-2, SARS-CoV, and hCoV-NL63 bind equine ACE2 Authors (2) Philipp NawrathAntoni Wrobel Structure Published 6 October 2022 Crick labsSteve GamblinFull details WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed Authors (19)Mary Wu Edward J Carr Ruth HarveyHarriet MearsSvend Kjaer Hermaleigh Townsley[...] Bryan WilliamsSonia GandhiCharles Swanton Emma C WallDavid LV Bauer The Lancet Published 17 December 2022 Crick labs/ facilitiesCharles SwantonNicola LewisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH Authors (7)Eva Garcia MoroJie ZhangLesley Calder Nick R BrownSteve Gamblin John J SkehelPeter Rosenthal Proceedings of the National Academy of Sciences of USA Published 16 August 2022 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningPeptide ChemistryFlow CytometryCell ServicesBiological Research FacilityFull details Determination of histone methyltransferase structure by crystallography Authors (1)Jon Wilson Methods in Molecular Biology Published 23 June 2022 Crick labsSteve GamblinFull details Evolution of the SARS-CoV-2 spike protein in thehuman host Authors (9)Antoni WrobelDonald BentonChloe RoustanAnnabel BorgSaira Hussain Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 4 March 2022 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinDavid LV BauerWorldwide Influenza CentreStructural BiologyScientific computingFull details Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19) Edward J CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C Wall Edward J Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Development of high affinity broadly reactive aptamers for spike protein of multiple SARS-CoV-2 variants Authors (4) Thao T LeDonald BentonAntoni WrobelSteve Gamblin RSC Advances: an international journal to further the chemical sciences Published 19 May 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike Authors (1)Antoni Wrobel Current Opinion in Structural Biology Published 1 August 2023 Crick labsSteve GamblinFull details
Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer Authors (67)Mary WuScott Shepherd Annika Fendler Edward J CarrLewis Au Ruth Harvey[...] Emma Nicholson James Larkin Emma C WallSamra Turajlic CAPTURE consortium Cancer Cell Published 8 May 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient Authors (24) Lena Jaki Sebastian Weigang Lisa Kern Stefanie KrammeAntoni Wrobel Andrea B Grawitz[...] Thomas Welte Georg Kochs Daniela Huzly Marcus Panning Jonas Fuchs Nature Communications Published 10 April 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein Authors (13) Valeria CalvaresiAntoni Wrobel Joanna Toporowska Dietmar Hammerschmid Katie J Doores Richard T Bradshaw[...]Chloe Roustan Eamonn Reading Michael H MalimSteve Gamblin Argyris Politis Nature Communications Published 14 March 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern Authors (22)Edgar Gonzalez-RodriguezMia Zol-HanlonGanka Bineva-ToddAndrea MarchesiMark Skehel Keira E Mahoney[...]Robert Wilkinson Emma C Wall Ramón Hurtado-Guerrero Stacy A MalakerBen Schumann ACS Central Science Published 22 March 2023 Crick labs/ facilitiesRobert J WilkinsonBen SchumannSteve GamblinStructural BiologyProteomicsChemical BiologyFull details
Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details
Hold your horses: The receptor-binding domains of SARS-CoV-2, SARS-CoV, and hCoV-NL63 bind equine ACE2 Authors (2) Philipp NawrathAntoni Wrobel Structure Published 6 October 2022 Crick labsSteve GamblinFull details
WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed Authors (19)Mary Wu Edward J Carr Ruth HarveyHarriet MearsSvend Kjaer Hermaleigh Townsley[...] Bryan WilliamsSonia GandhiCharles Swanton Emma C WallDavid LV Bauer The Lancet Published 17 December 2022 Crick labs/ facilitiesCharles SwantonNicola LewisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details
Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details
Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH Authors (7)Eva Garcia MoroJie ZhangLesley Calder Nick R BrownSteve Gamblin John J SkehelPeter Rosenthal Proceedings of the National Academy of Sciences of USA Published 16 August 2022 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningPeptide ChemistryFlow CytometryCell ServicesBiological Research FacilityFull details
Determination of histone methyltransferase structure by crystallography Authors (1)Jon Wilson Methods in Molecular Biology Published 23 June 2022 Crick labsSteve GamblinFull details
Evolution of the SARS-CoV-2 spike protein in thehuman host Authors (9)Antoni WrobelDonald BentonChloe RoustanAnnabel BorgSaira Hussain Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 4 March 2022 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinDavid LV BauerWorldwide Influenza CentreStructural BiologyScientific computingFull details
Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19) Edward J CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C Wall Edward J Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details