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Breadcrumb Steve Gamblin Gamblin lab Structural Biology of Disease Processes Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Structures of proteins investigated in the Gamblin lab: AMPK, PRC2 and influenza hemagglutinin (left to right). Toggle to view hero caption PublicationsYear published2024 (1)2023 (4)2022 (3)2021 (5)2020 (5)2018 (1) Facet Year publishedResearch topicsCell Biology (19)Cell Cycle & Chromosomes (19)Infectious Disease (19)Metabolism (19)Model Organisms (19)Structural Biology & Biophysics (19)Chemical Biology & High Throughput (17)Computational & Systems Biology (11)Genetics & Genomics (11)Immunology (11)Genome Integrity & Repair (10)Human Biology & Physiology (10)Stem Cells (10)Tumour Biology (10)Neurosciences (9)Signalling & Oncogenes (9)Biochemistry & Proteomics (5)Developmental Biology (5)Gene Expression (3)Synthetic Biology (3)Microfabrication & Bioengineering (2) (-)Imaging (19) Facet Research topicsPublication typeJournal article (19)Primary research (16)Letter (3) Facet Publication typeJournalThe Lancet (4)Nature Communications (3)Lancet Infectious Diseases (2)Nature (2)Proceedings of the National Academy of Sciences of USA (2)Cancer Cell (1)Nature Aging (1)Nature Structural & Molecular Biology (1)PLOS Biology (1)Proceedings of the National Academy of Sciences of the United States of America (1)Science advances (1) Facet Journal Publications Displaying 1 - 19 of 19Last updated : 29 March 2024 03:50 Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details SARS-CoV-2 mucosal neutralising immunity after vaccination Authors (38)Edward Carr Guilia Dowgier David Greenwood Lou S Herman Agnieszka Hobbs Martina Ragno[...]Charles SwantonSonia GandhiDavid LV Bauer Emma WallMary Wu Lancet Infectious Diseases Published 1 January 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingFull details Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection Authors (36)Edward CarrMary Wu Joshua Gahir Ruth Harvey Hermaleigh Townsley Chris Bailey[...]Charles SwantonSonia GandhiDavid LV Bauer Emma C Wall Crick COVID Serology Consortium Lancet Infectious Diseases Published 1 July 2023 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingScientific computingFull details Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH Authors (7)Eva Garcia MoroJie ZhangLesley Calder Nick R BrownSteve Gamblin John J SkehelPeter Rosenthal Proceedings of the National Academy of Sciences of USA Published 16 August 2022 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details Evolution of the SARS-CoV-2 spike protein in thehuman host Authors (9)Antoni WrobelDonald BentonChloe RoustanAnnabel BorgSaira Hussain Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 4 March 2022 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinDavid LV BauerWorldwide Influenza CentreStructural BiologyScientific computingFull details Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients Authors (86)Edward Carr Mary Wu Ruth Harvey Emma C WallGavin KellySaira Hussain[...]Emma RussellAndy RiddellSvend KjaerAnnabel BorgChloe Roustan The Lancet Published 18 September 2021 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity Authors (40)Annachiara RosaVal Pye Carl Graham Luke Muir Jeffrey SeowKevin Ng[...] Richard S TedderGeorge Kassiotis Laura E Mccoy Katie J DooresPeter Cherepanov Science advances Published 28 May 2021 Crick labs/ facilitiesPeter RosenthalGeorge KassiotisSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsFlow CytometryFull details The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2 Authors (9)Donald BentonAntoni WrobelChloe RoustanAnnabel Borg Pengqi Xu Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Proceedings of the National Academy of Sciences of USA Published 2 March 2021 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2 Authors (10)Antoni WrobelDonald Benton Pengqi XuLesley CalderAnnabel BorgChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 5 February 2021 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein Authors (9)Antoni WrobelDonald BentonSaira Hussain Ruth Harvey Stephen R MartinChloe RoustanPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 21 October 2020 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyScientific computingFull details Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion Authors (8)Donald BentonAntoni Wrobel Pengqi XuChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Published 10 December 2020 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects Authors (8)Antoni WrobelDonald Benton Pengqi XuChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Structural & Molecular Biology Published 1 August 2020 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details Structural transitions in influenza haemagglutinin at membrane fusion pH Authors (4)Donald BentonSteve GamblinPeter Rosenthal John J Skehel Nature Published 2 July 2020 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details Influenza hemagglutinin membrane anchor Authors (13)Donald BentonAndrea NansLesley CalderJack Turner Ursula Neu Yi Pu Lin[...] Davide Corti Antonio LanzavecchiaSteve GamblinPeter Rosenthal John J Skehel Proceedings of the National Academy of Sciences of the United States of America Published 17 September 2018 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyElectron MicroscopyFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details
SARS-CoV-2 mucosal neutralising immunity after vaccination Authors (38)Edward Carr Guilia Dowgier David Greenwood Lou S Herman Agnieszka Hobbs Martina Ragno[...]Charles SwantonSonia GandhiDavid LV Bauer Emma WallMary Wu Lancet Infectious Diseases Published 1 January 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingFull details
Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details
Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection Authors (36)Edward CarrMary Wu Joshua Gahir Ruth Harvey Hermaleigh Townsley Chris Bailey[...]Charles SwantonSonia GandhiDavid LV Bauer Emma C Wall Crick COVID Serology Consortium Lancet Infectious Diseases Published 1 July 2023 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingScientific computingFull details
Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details
Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH Authors (7)Eva Garcia MoroJie ZhangLesley Calder Nick R BrownSteve Gamblin John J SkehelPeter Rosenthal Proceedings of the National Academy of Sciences of USA Published 16 August 2022 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
Evolution of the SARS-CoV-2 spike protein in thehuman host Authors (9)Antoni WrobelDonald BentonChloe RoustanAnnabel BorgSaira Hussain Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 4 March 2022 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinDavid LV BauerWorldwide Influenza CentreStructural BiologyScientific computingFull details
Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients Authors (86)Edward Carr Mary Wu Ruth Harvey Emma C WallGavin KellySaira Hussain[...]Emma RussellAndy RiddellSvend KjaerAnnabel BorgChloe Roustan The Lancet Published 18 September 2021 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details
SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity Authors (40)Annachiara RosaVal Pye Carl Graham Luke Muir Jeffrey SeowKevin Ng[...] Richard S TedderGeorge Kassiotis Laura E Mccoy Katie J DooresPeter Cherepanov Science advances Published 28 May 2021 Crick labs/ facilitiesPeter RosenthalGeorge KassiotisSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsFlow CytometryFull details
The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2 Authors (9)Donald BentonAntoni WrobelChloe RoustanAnnabel Borg Pengqi Xu Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Proceedings of the National Academy of Sciences of USA Published 2 March 2021 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2 Authors (10)Antoni WrobelDonald Benton Pengqi XuLesley CalderAnnabel BorgChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 5 February 2021 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein Authors (9)Antoni WrobelDonald BentonSaira Hussain Ruth Harvey Stephen R MartinChloe RoustanPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 21 October 2020 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyScientific computingFull details
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion Authors (8)Donald BentonAntoni Wrobel Pengqi XuChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Published 10 December 2020 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects Authors (8)Antoni WrobelDonald Benton Pengqi XuChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Structural & Molecular Biology Published 1 August 2020 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
Structural transitions in influenza haemagglutinin at membrane fusion pH Authors (4)Donald BentonSteve GamblinPeter Rosenthal John J Skehel Nature Published 2 July 2020 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
Influenza hemagglutinin membrane anchor Authors (13)Donald BentonAndrea NansLesley CalderJack Turner Ursula Neu Yi Pu Lin[...] Davide Corti Antonio LanzavecchiaSteve GamblinPeter Rosenthal John J Skehel Proceedings of the National Academy of Sciences of the United States of America Published 17 September 2018 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyElectron MicroscopyFull details