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Breadcrumb Steve Gamblin Gamblin lab Structural Biology of Disease Processes Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Structures of proteins investigated in the Gamblin lab: AMPK, PRC2 and influenza hemagglutinin (left to right). Toggle to view hero caption PublicationsYear published (-)2021 (13) Facet Year publishedResearch topicsCell Cycle & Chromosomes (13)Infectious Disease (13)Metabolism (13)Model Organisms (13)Structural Biology & Biophysics (13)Cell Biology (11)Chemical Biology & High Throughput (11)Computational & Systems Biology (11)Genetics & Genomics (11)Immunology (11)Genome Integrity & Repair (10)Signalling & Oncogenes (10)Human Biology & Physiology (9)Stem Cells (9)Tumour Biology (9)Neurosciences (8)Biochemistry & Proteomics (6)Developmental Biology (5)Imaging (5)Gene Expression (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (13)Primary research (12)Review (1) Facet Publication typeJournalNature Cancer (3)The Lancet (2)Cancer Cell (1)eLife (1)Lancet (1)Med (1)Nature Communications (1)Proceedings of the National Academy of Sciences of USA (1)Science advances (1)Seminars in Immunology (1) Facet Journal Publications Displaying 1 - 13 of 13Last updated : 29 March 2024 03:22 Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Heterologous humoral immunity to human and zoonotic coronaviruses: Aiming for the achilles heel Authors (5)Kevin NgNikhil FaulknerAntoni WrobelSteve GamblinGeorge Kassiotis Seminars in Immunology Published 1 June 2021 Crick labsGeorge KassiotisSteve GamblinFull details Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases Authors (31) Claire T Deakin Georgina H CornishKevin NgNikhil Faulkner William BollandJoshua Hope[...] Michael LevinPeter Cherepanov Coziana Ciurtin Lucy R WedderburnGeorge Kassiotis Med Published 10 September 2021 Crick labs/ facilitiesNeil McDonaldNicola LewisGeorge KassiotisSteve GamblinPeter Cherepanov Worldwide Influenza CentreFlow CytometryCell ServicesFull details Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients Authors (86)Edward Carr Mary Wu Ruth Harvey Emma C WallGavin KellySaira Hussain[...]Emma RussellAndy RiddellSvend KjaerAnnabel BorgChloe Roustan The Lancet Published 18 September 2021 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains Authors (30)Nikhil FaulknerKevin NgMary Wu Ruth Harvey Marios Margaritis Stavroula Paraskevopoulou[...]Michael HowellDavid LV Bauer Eleni Nastouli SAFER InvestigatorsGeorge Kassiotis eLife Published 29 July 2021 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesFull details AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC Authors (24) Emma C WallMary Wu Ruth HarveyGavin KellyScott WarchalChelsea Sawyer[...] Vincenzo Libri Bryan WilliamsCharles SwantonSonia GandhiDavid LV Bauer Lancet Published 17 July 2021 Crick labs/ facilitiesCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsScientific computingFull details Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination Authors (25) Emma C WallMary Wu Ruth HarveyGavin KellyScott WarchalChelsea Sawyer[...] Vincenzo Libri Bryan WilliamsCharles SwantonSonia GandhiDavid LV Bauer The Lancet Published 19 June 2021 Crick labs/ facilitiesCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity Authors (40)Annachiara RosaVal Pye Carl Graham Luke Muir Jeffrey SeowKevin Ng[...] Richard S TedderGeorge Kassiotis Laura E Mccoy Katie J DooresPeter Cherepanov Science advances Published 28 May 2021 Crick labs/ facilitiesPeter RosenthalGeorge KassiotisSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsFlow CytometryFull details The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2 Authors (9)Donald BentonAntoni WrobelChloe RoustanAnnabel Borg Pengqi Xu Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Proceedings of the National Academy of Sciences of USA Published 2 March 2021 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2 Authors (10)Antoni WrobelDonald Benton Pengqi XuLesley CalderAnnabel BorgChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 5 February 2021 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Heterologous humoral immunity to human and zoonotic coronaviruses: Aiming for the achilles heel Authors (5)Kevin NgNikhil FaulknerAntoni WrobelSteve GamblinGeorge Kassiotis Seminars in Immunology Published 1 June 2021 Crick labsGeorge KassiotisSteve GamblinFull details
Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases Authors (31) Claire T Deakin Georgina H CornishKevin NgNikhil Faulkner William BollandJoshua Hope[...] Michael LevinPeter Cherepanov Coziana Ciurtin Lucy R WedderburnGeorge Kassiotis Med Published 10 September 2021 Crick labs/ facilitiesNeil McDonaldNicola LewisGeorge KassiotisSteve GamblinPeter Cherepanov Worldwide Influenza CentreFlow CytometryCell ServicesFull details
Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients Authors (86)Edward Carr Mary Wu Ruth Harvey Emma C WallGavin KellySaira Hussain[...]Emma RussellAndy RiddellSvend KjaerAnnabel BorgChloe Roustan The Lancet Published 18 September 2021 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details
Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains Authors (30)Nikhil FaulknerKevin NgMary Wu Ruth Harvey Marios Margaritis Stavroula Paraskevopoulou[...]Michael HowellDavid LV Bauer Eleni Nastouli SAFER InvestigatorsGeorge Kassiotis eLife Published 29 July 2021 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesFull details
AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC Authors (24) Emma C WallMary Wu Ruth HarveyGavin KellyScott WarchalChelsea Sawyer[...] Vincenzo Libri Bryan WilliamsCharles SwantonSonia GandhiDavid LV Bauer Lancet Published 17 July 2021 Crick labs/ facilitiesCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsScientific computingFull details
Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination Authors (25) Emma C WallMary Wu Ruth HarveyGavin KellyScott WarchalChelsea Sawyer[...] Vincenzo Libri Bryan WilliamsCharles SwantonSonia GandhiDavid LV Bauer The Lancet Published 19 June 2021 Crick labs/ facilitiesCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity Authors (40)Annachiara RosaVal Pye Carl Graham Luke Muir Jeffrey SeowKevin Ng[...] Richard S TedderGeorge Kassiotis Laura E Mccoy Katie J DooresPeter Cherepanov Science advances Published 28 May 2021 Crick labs/ facilitiesPeter RosenthalGeorge KassiotisSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsFlow CytometryFull details
The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2 Authors (9)Donald BentonAntoni WrobelChloe RoustanAnnabel Borg Pengqi Xu Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Proceedings of the National Academy of Sciences of USA Published 2 March 2021 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2 Authors (10)Antoni WrobelDonald Benton Pengqi XuLesley CalderAnnabel BorgChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 5 February 2021 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details