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Breadcrumb Steve Gamblin Gamblin lab Structural Biology of Disease Processes Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Structures of proteins investigated in the Gamblin lab: AMPK, PRC2 and influenza hemagglutinin (left to right). Toggle to view hero caption PublicationsYear published2024 (3)2023 (12)2022 (10)2021 (13)2020 (12)2019 (4)2018 (4)2017 (2)2016 (6)2015 (3)2014 (5)2013 (5)2012 (4)2011 (5)2010 (3) Facet Year publishedResearch topicsInfectious Disease (68)Cell Cycle & Chromosomes (67)Metabolism (67)Structural Biology & Biophysics (67)Chemical Biology & High Throughput (50)Model Organisms (39)Cell Biology (38)Computational & Systems Biology (32)Genetics & Genomics (32)Genome Integrity & Repair (30)Immunology (30)Human Biology & Physiology (29)Tumour Biology (28)Stem Cells (27)Neurosciences (26)Signalling & Oncogenes (26)Imaging (19)Biochemistry & Proteomics (17)Developmental Biology (10)Synthetic Biology (4)Gene Expression (3)Microfabrication & Bioengineering (2) Facet Research topicsPublication typeJournal article (91)Primary research (68)Review (8)Letter (7)Commentary (3)Method (3)Case report (1)Obituary (1) Facet Publication typeJournalThe Lancet (10)Nature (7)Nature Communications (7)Proceedings of the National Academy of Sciences of the United States of America (4)Journal of Virology (3)Nature Cancer (3)Science (3)Biochemical Journal (2)Cancer Cell (2)Cell (2)Current Opinion in Structural Biology (2)Lancet Infectious Diseases (2)Methods in Molecular Biology (2)PLOS Biology (2)PLOS Pathogens (2)Proceedings of the National Academy of Sciences of USA (2)Structure (2)Virology (2)ACS Central Science (1)Cell Host and Microbe (1)Cell Metabolism (1)Cell Reports (1)Cell Reports Medicine (1)Cold Spring Harbor Perspectives in Medicine (1)eLife (1)Emerging Microbes & Infections (1)Europace (1)Frontiers in Immunology (1)Journal of Biological Chemistry (1)Journal of Infectious Diseases (1)Journal of Medicinal Chemistry (1)Journal of Molecular Biology (1)Lancet (1)Med (1)Microbiology Today (1)Molecular Cell (1)Nature Aging (1)Nature Biotechnology (1)Nature Chemical Biology (1)Nature Genetics (1)Nature Structural & Molecular Biology (1)Nature Structural and Molecular Biology (1)Nucleic Acids Research (1)PLOS ONE (1)RSC Advances: an international journal to further the chemical sciences (1)Science advances (1)Science Translational Medicine (1)Seminars in Immunology (1)Trends in Biochemical Sciences (1)Virus Research (1) Facet Journal Publications Displaying 1 - 20 of 91Last updated : 29 March 2024 02:30 COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 11 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details SARS-CoV-2 mucosal neutralising immunity after vaccination Authors (38)Edward Carr Guilia Dowgier David Greenwood Lou S Herman Agnieszka Hobbs Martina Ragno[...]Charles SwantonSonia GandhiDavid LV Bauer Emma WallMary Wu Lancet Infectious Diseases Published 1 January 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingFull details TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry Authors (25) Jim Baggen Maarten Jacquemyn Leentje Persoons Els VanstreelsVal PyeAntoni Wrobel[...] Alusha Andre Mamchak Maxime Ah Young-Chapon Eric BrownPeter Cherepanov Dirk Daelemans Cell Published 3 August 2023 Crick labs/ facilitiesSteve GamblinPeter Cherepanov Structural BiologyFull details Evolutionarily conserved amino acids in MHC-II mediate bat influenza A virus entry into human cells Authors (11) Okikiola M Olajide Maria Kaukab Osman Jonathan Robert Susanne Kessler Lina Kathrin Toews Thiprampai Thamamongood Jacques NeefjesAntoni Wrobel Martin Schwemmle Kevin Ciminski Peter Reuther PLOS Biology Published 6 July 2023 Crick labsSteve GamblinFull details Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection Authors (36)Edward CarrMary Wu Joshua Gahir Ruth Harvey Hermaleigh Townsley Chris Bailey[...]Charles SwantonSonia GandhiDavid LV Bauer Emma C Wall Crick COVID Serology Consortium Lancet Infectious Diseases Published 1 July 2023 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingScientific computingFull details Development of high affinity broadly reactive aptamers for spike protein of multiple SARS-CoV-2 variants Authors (4) Thao T LeDonald BentonAntoni WrobelSteve Gamblin RSC Advances: an international journal to further the chemical sciences Published 19 May 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike Authors (1)Antoni Wrobel Current Opinion in Structural Biology Published 1 August 2023 Crick labsSteve GamblinFull details Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer Authors (67)Mary WuScott Shepherd Annika FendlerEdward CarrLewis Au Ruth Harvey[...] Emma Nicholson James Larkin Emma C WallSamra Turajlic CAPTURE consortium Cancer Cell Published 8 May 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient Authors (24) Lena Jaki Sebastian Weigang Lisa Kern Stefanie KrammeAntoni Wrobel Andrea B Grawitz[...] Thomas Welte Georg Kochs Daniela Huzly Marcus Panning Jonas Fuchs Nature Communications Published 10 April 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein Authors (13) Valeria CalvaresiAntoni Wrobel Joanna Toporowska Dietmar Hammerschmid Katie J Doores Richard T Bradshaw[...]Chloe Roustan Eamonn Reading Michael H MalimSteve Gamblin Argyris Politis Nature Communications Published 14 March 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern Authors (22)Edgar Gonzalez-RodriguezMia Zol-HanlonGanka Bineva-ToddAndrea MarchesiMark Skehel Keira E Mahoney[...]Robert Wilkinson Emma C Wall Ramón Hurtado-Guerrero Stacy A MalakerBen Schumann ACS Central Science Published 22 March 2023 Crick labs/ facilitiesRobert J WilkinsonBen SchumannSteve GamblinStructural BiologyProteomicsChemical BiologyFull details Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details Hold your horses: The receptor-binding domains of SARS-CoV-2, SARS-CoV, and hCoV-NL63 bind equine ACE2 Authors (2) Philipp NawrathAntoni Wrobel Structure Published 6 October 2022 Crick labsSteve GamblinFull details WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed Authors (19)Mary WuEdward Carr Ruth HarveyHarriet MearsSvend Kjaer Hermaleigh Townsley[...] Bryan WilliamsSonia GandhiCharles Swanton Emma C WallDavid LV Bauer The Lancet Published 17 December 2022 Crick labs/ facilitiesCharles SwantonNicola LewisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH Authors (7)Eva Garcia MoroJie ZhangLesley Calder Nick R BrownSteve Gamblin John J SkehelPeter Rosenthal Proceedings of the National Academy of Sciences of USA Published 16 August 2022 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 11 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details
SARS-CoV-2 mucosal neutralising immunity after vaccination Authors (38)Edward Carr Guilia Dowgier David Greenwood Lou S Herman Agnieszka Hobbs Martina Ragno[...]Charles SwantonSonia GandhiDavid LV Bauer Emma WallMary Wu Lancet Infectious Diseases Published 1 January 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingFull details
TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry Authors (25) Jim Baggen Maarten Jacquemyn Leentje Persoons Els VanstreelsVal PyeAntoni Wrobel[...] Alusha Andre Mamchak Maxime Ah Young-Chapon Eric BrownPeter Cherepanov Dirk Daelemans Cell Published 3 August 2023 Crick labs/ facilitiesSteve GamblinPeter Cherepanov Structural BiologyFull details
Evolutionarily conserved amino acids in MHC-II mediate bat influenza A virus entry into human cells Authors (11) Okikiola M Olajide Maria Kaukab Osman Jonathan Robert Susanne Kessler Lina Kathrin Toews Thiprampai Thamamongood Jacques NeefjesAntoni Wrobel Martin Schwemmle Kevin Ciminski Peter Reuther PLOS Biology Published 6 July 2023 Crick labsSteve GamblinFull details
Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details
Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection Authors (36)Edward CarrMary Wu Joshua Gahir Ruth Harvey Hermaleigh Townsley Chris Bailey[...]Charles SwantonSonia GandhiDavid LV Bauer Emma C Wall Crick COVID Serology Consortium Lancet Infectious Diseases Published 1 July 2023 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingScientific computingFull details
Development of high affinity broadly reactive aptamers for spike protein of multiple SARS-CoV-2 variants Authors (4) Thao T LeDonald BentonAntoni WrobelSteve Gamblin RSC Advances: an international journal to further the chemical sciences Published 19 May 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike Authors (1)Antoni Wrobel Current Opinion in Structural Biology Published 1 August 2023 Crick labsSteve GamblinFull details
Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer Authors (67)Mary WuScott Shepherd Annika FendlerEdward CarrLewis Au Ruth Harvey[...] Emma Nicholson James Larkin Emma C WallSamra Turajlic CAPTURE consortium Cancer Cell Published 8 May 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient Authors (24) Lena Jaki Sebastian Weigang Lisa Kern Stefanie KrammeAntoni Wrobel Andrea B Grawitz[...] Thomas Welte Georg Kochs Daniela Huzly Marcus Panning Jonas Fuchs Nature Communications Published 10 April 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein Authors (13) Valeria CalvaresiAntoni Wrobel Joanna Toporowska Dietmar Hammerschmid Katie J Doores Richard T Bradshaw[...]Chloe Roustan Eamonn Reading Michael H MalimSteve Gamblin Argyris Politis Nature Communications Published 14 March 2023 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern Authors (22)Edgar Gonzalez-RodriguezMia Zol-HanlonGanka Bineva-ToddAndrea MarchesiMark Skehel Keira E Mahoney[...]Robert Wilkinson Emma C Wall Ramón Hurtado-Guerrero Stacy A MalakerBen Schumann ACS Central Science Published 22 March 2023 Crick labs/ facilitiesRobert J WilkinsonBen SchumannSteve GamblinStructural BiologyProteomicsChemical BiologyFull details
Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details
Hold your horses: The receptor-binding domains of SARS-CoV-2, SARS-CoV, and hCoV-NL63 bind equine ACE2 Authors (2) Philipp NawrathAntoni Wrobel Structure Published 6 October 2022 Crick labsSteve GamblinFull details
WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed Authors (19)Mary WuEdward Carr Ruth HarveyHarriet MearsSvend Kjaer Hermaleigh Townsley[...] Bryan WilliamsSonia GandhiCharles Swanton Emma C WallDavid LV Bauer The Lancet Published 17 December 2022 Crick labs/ facilitiesCharles SwantonNicola LewisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details
Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details
Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH Authors (7)Eva Garcia MoroJie ZhangLesley Calder Nick R BrownSteve Gamblin John J SkehelPeter Rosenthal Proceedings of the National Academy of Sciences of USA Published 16 August 2022 Crick labs/ facilitiesPeter RosenthalSteve GamblinStructural BiologyScientific computingFull details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details