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Breadcrumb Steve Gamblin Gamblin lab Structural Biology of Disease Processes Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Structures of proteins investigated in the Gamblin lab: AMPK, PRC2 and influenza hemagglutinin (left to right). 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Research (1)PLOS ONE (1)RSC Advances: an international journal to further the chemical sciences (1)Science advances (1)Science Translational Medicine (1)Seminars in Immunology (1)Trends in Biochemical Sciences (1)Virus Research (1) Facet Journal Publications Displaying 61 - 80 of 91Last updated : 20 April 2024 02:26 Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2" Authors (4) Ying Zhang Neil JustinJon WilsonSteve Gamblin Science Published 23 December 2016 Crick labsSteve GamblinFull details Expression cloning and production of human heavy-chain-only antibodies from murine transgenic plasma cells Authors (7) D Drabek R Janssens E de Boer R Rademaker J Kloess J Skehel F Grosveld Frontiers in Immunology Published 19 December 2016 Crick labsSteve GamblinFull details Identification of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a potent and selective inhibitor of histone methyltransferase EZH2, suitabl Authors (25) Rishi G Vaswani Victor S Gehling Les A Dakin Andrew S Cook Christopher G Nasveschuk Martin Duplessis[...]Ying ZhangNeil JustinShuyang ChenJon WilsonSteve Gamblin Journal of Medicinal Chemistry Published 10 November 2016 Crick labsSteve GamblinFull details The role of the B-allele of the influenza A virus segment 8 in setting mammalian host range and pathogenicity Authors (20) Matthew L Turnbull Helen M Wise Marlynne Q Nicol Nikki Smith Rebecca L Dunfee Philippa M Beard[...] Jeffery K Taubenberger Samantha J Lycett Michael P Weekes Bernadette M Dutia Paul Digard Journal of Virology Published 15 October 2016 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreFull details Structure and function analysis of an antibody recognizing all influenza A subtypes Authors (29) Nicole L Kallewaard Davide Corti Patrick J Collins Ursula Neu Josephine M McAuliffe Ebony Benjamin[...] JoAnn A Suzich Antonio Lanzavecchia Qing ZhuSteve Gamblin John J Skehel Cell Published 28 July 2016 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2 Authors (12)Neil JustinYing Zhang Cataldo Tarricone Stephen R MartinShuyang Chen Elizabeth Underwood[...] Lesley F HairePhilip Walker Danny ReinbergJon WilsonSteve Gamblin Nature Communications Published 28 April 2016 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Evolving catalytic properties of the MLL family SET domain Authors (6)Ying Zhang Anshumali Mittal James Reid Stephanie ReichSteve GamblinJon Wilson Structure Published 6 October 2015 Crick labsSteve GamblinFull details Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody Authors (18) X Xiong D Corti J Liu D Pinna M FoglieriniLesley Calder[...] NJ Temperton K Subbarao A LanzavecchiaSteve Gamblin JJ Skehel Proceedings of the National Academy of Sciences of the United States of America Published 28 July 2015 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyFull details Jarid2 methylation via the PRC2 complex regulates H3K27me3 deposition during cell differentiation Authors (17) Serena SanulliNeil Justin Aurélie Teissandier Katia Ancelin Manuela Portoso Matthieu Caron[...] Michel Wassef Fabienne BurlinaSteve Gamblin Edith Heard Raphaël Margueron Molecular Cell Published 5 March 2015 Crick labsSteve GamblinFull details Recent evolution of equine influenza and the origin of canine influenza Authors (9) Patrick J Collins Sebastien G Vachieri Lesley F HaireRoksana Ogrodowicz Stephen R MartinPhilip Walker Xiaoli XiongSteve Gamblin John J Skehel Proceedings of the National Academy of Sciences of the United States of America Published 14 July 2014 Crick labs/ facilitiesNicola LewisSteve GamblinStructural BiologyFull details Receptor binding by H10 influenza viruses Authors (10) Sebastien G Vachieri Xiaoli Xiong Patrick J CollinsPhilip Walker Stephen R Martin Lesley F Haire Ying ZhangJohn MccauleySteve Gamblin John J Skehel Nature Published 28 May 2014 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyFull details Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment Authors (12) Sarah Cooper Martin Dienstbier Raihann Hassan Lothar Schermelleh Jafar Sharif Neil P Blackledge[...] Sarah Elderkin Haruhiko Koseki Robert Klose Andreas Heger Neil Brockdorff Cell Reports Published 21 May 2014 Crick labsSteve GamblinFull details A novel I221L substitution in neuraminidase confers high-level resistance to oseltamivir in influenza B viruses Authors (17) Vanessa Escuret Patrick J Collins Jean-Sébastien Casalegno Sebastien G Vachieri Nicholas Cattle Olivier Ferraris[...] Martine Valette Michèle OttmannJohn Mccauley Rodney S Daniels Bruno Lina Journal of Infectious Diseases Published 3 May 2014 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreFull details Enhanced human receptor binding by H5 haemagglutinins Authors (12) Xiaoli Xiong Haixia Xiao Stephen R Martin Peter J Coombs Junfeng Liu Patrick J Collins[...]Philip Walker Yi Pu LinJohn MccauleySteve Gamblin John J Skehel Virology Published 1 May 2014 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyFull details Structural basis of AMPK regulation by small molecule activators Authors (14) Bing Xiao Matthew J Sanders David Carmena Nicola J Bright Lesley F Haire Elizabeth Underwood[...] Stefan Hallen Fabrizio Giordanetto Stephen R Martin David CarlingSteve Gamblin Nature Communications Published 19 December 2013 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details Changes in the hemagglutinin of H5N1 viruses during human infection - influence on receptor binding Authors (28) Martin Crusat Junfeng Liu Angelina S Palma Robert A Childs Yan Liu Stephen A Wharton[...] John J Skehel Alan J Hay Jeremy Farrar Menno D de Jong Ten Feizi Virology Published 17 September 2013 Crick labs/ facilitiesNicola LewisSteve GamblinStructural BiologyFull details Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus Authors (8) X Xiong A Tuzikov PJ Coombs S MartinPhilip WalkerSteve Gamblin N Bovin JJ Skehel Virus Research Published 10 September 2013 Crick labs/ facilitiesNicola LewisSteve GamblinStructural BiologyFull details Receptor binding by a ferret-transmissible H5 avian influenza virus Authors (12) X Xiong PJ Coombs SR Martin J Liu H XiaoJohn Mccauley[...]Philip Walker PJ Collins Y Kawaoka JJ SkehelSteve Gamblin Nature Published 1 January 2013 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyFull details Receptor binding by an H7N9 influenza virus from humans Authors (11) Xiaoli Xiong Stephen R Martin Lesley F Haire Stephen A Wharton Rodney S Daniels Michael S BennettJohn Mccauley Patrick J CollinsPhilip Walker John J SkehelSteve Gamblin Nature Published 1 January 2013 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyFull details A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses Authors (17) Hongxing Hu Jarrod Voss Guoliang Zhang Philippi Buchy Teng Zuo Lulan Wang[...] Linqi Zhang Vincent Deubel Boping Zhou John J Skehel Paul Zhou Journal of Virology Published 11 January 2012 Crick labsSteve GamblinFull details Pagination First page First Previous page Previous Page 1 Page 2 Page 3 Current page 4 Page 5 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2" Authors (4) Ying Zhang Neil JustinJon WilsonSteve Gamblin Science Published 23 December 2016 Crick labsSteve GamblinFull details
Expression cloning and production of human heavy-chain-only antibodies from murine transgenic plasma cells Authors (7) D Drabek R Janssens E de Boer R Rademaker J Kloess J Skehel F Grosveld Frontiers in Immunology Published 19 December 2016 Crick labsSteve GamblinFull details
Identification of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a potent and selective inhibitor of histone methyltransferase EZH2, suitabl Authors (25) Rishi G Vaswani Victor S Gehling Les A Dakin Andrew S Cook Christopher G Nasveschuk Martin Duplessis[...]Ying ZhangNeil JustinShuyang ChenJon WilsonSteve Gamblin Journal of Medicinal Chemistry Published 10 November 2016 Crick labsSteve GamblinFull details
The role of the B-allele of the influenza A virus segment 8 in setting mammalian host range and pathogenicity Authors (20) Matthew L Turnbull Helen M Wise Marlynne Q Nicol Nikki Smith Rebecca L Dunfee Philippa M Beard[...] Jeffery K Taubenberger Samantha J Lycett Michael P Weekes Bernadette M Dutia Paul Digard Journal of Virology Published 15 October 2016 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreFull details
Structure and function analysis of an antibody recognizing all influenza A subtypes Authors (29) Nicole L Kallewaard Davide Corti Patrick J Collins Ursula Neu Josephine M McAuliffe Ebony Benjamin[...] JoAnn A Suzich Antonio Lanzavecchia Qing ZhuSteve Gamblin John J Skehel Cell Published 28 July 2016 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2 Authors (12)Neil JustinYing Zhang Cataldo Tarricone Stephen R MartinShuyang Chen Elizabeth Underwood[...] Lesley F HairePhilip Walker Danny ReinbergJon WilsonSteve Gamblin Nature Communications Published 28 April 2016 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Evolving catalytic properties of the MLL family SET domain Authors (6)Ying Zhang Anshumali Mittal James Reid Stephanie ReichSteve GamblinJon Wilson Structure Published 6 October 2015 Crick labsSteve GamblinFull details
Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody Authors (18) X Xiong D Corti J Liu D Pinna M FoglieriniLesley Calder[...] NJ Temperton K Subbarao A LanzavecchiaSteve Gamblin JJ Skehel Proceedings of the National Academy of Sciences of the United States of America Published 28 July 2015 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyFull details
Jarid2 methylation via the PRC2 complex regulates H3K27me3 deposition during cell differentiation Authors (17) Serena SanulliNeil Justin Aurélie Teissandier Katia Ancelin Manuela Portoso Matthieu Caron[...] Michel Wassef Fabienne BurlinaSteve Gamblin Edith Heard Raphaël Margueron Molecular Cell Published 5 March 2015 Crick labsSteve GamblinFull details
Recent evolution of equine influenza and the origin of canine influenza Authors (9) Patrick J Collins Sebastien G Vachieri Lesley F HaireRoksana Ogrodowicz Stephen R MartinPhilip Walker Xiaoli XiongSteve Gamblin John J Skehel Proceedings of the National Academy of Sciences of the United States of America Published 14 July 2014 Crick labs/ facilitiesNicola LewisSteve GamblinStructural BiologyFull details
Receptor binding by H10 influenza viruses Authors (10) Sebastien G Vachieri Xiaoli Xiong Patrick J CollinsPhilip Walker Stephen R Martin Lesley F Haire Ying ZhangJohn MccauleySteve Gamblin John J Skehel Nature Published 28 May 2014 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyFull details
Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment Authors (12) Sarah Cooper Martin Dienstbier Raihann Hassan Lothar Schermelleh Jafar Sharif Neil P Blackledge[...] Sarah Elderkin Haruhiko Koseki Robert Klose Andreas Heger Neil Brockdorff Cell Reports Published 21 May 2014 Crick labsSteve GamblinFull details
A novel I221L substitution in neuraminidase confers high-level resistance to oseltamivir in influenza B viruses Authors (17) Vanessa Escuret Patrick J Collins Jean-Sébastien Casalegno Sebastien G Vachieri Nicholas Cattle Olivier Ferraris[...] Martine Valette Michèle OttmannJohn Mccauley Rodney S Daniels Bruno Lina Journal of Infectious Diseases Published 3 May 2014 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreFull details
Enhanced human receptor binding by H5 haemagglutinins Authors (12) Xiaoli Xiong Haixia Xiao Stephen R Martin Peter J Coombs Junfeng Liu Patrick J Collins[...]Philip Walker Yi Pu LinJohn MccauleySteve Gamblin John J Skehel Virology Published 1 May 2014 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyFull details
Structural basis of AMPK regulation by small molecule activators Authors (14) Bing Xiao Matthew J Sanders David Carmena Nicola J Bright Lesley F Haire Elizabeth Underwood[...] Stefan Hallen Fabrizio Giordanetto Stephen R Martin David CarlingSteve Gamblin Nature Communications Published 19 December 2013 Crick labs/ facilitiesSteve GamblinStructural BiologyFull details
Changes in the hemagglutinin of H5N1 viruses during human infection - influence on receptor binding Authors (28) Martin Crusat Junfeng Liu Angelina S Palma Robert A Childs Yan Liu Stephen A Wharton[...] John J Skehel Alan J Hay Jeremy Farrar Menno D de Jong Ten Feizi Virology Published 17 September 2013 Crick labs/ facilitiesNicola LewisSteve GamblinStructural BiologyFull details
Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus Authors (8) X Xiong A Tuzikov PJ Coombs S MartinPhilip WalkerSteve Gamblin N Bovin JJ Skehel Virus Research Published 10 September 2013 Crick labs/ facilitiesNicola LewisSteve GamblinStructural BiologyFull details
Receptor binding by a ferret-transmissible H5 avian influenza virus Authors (12) X Xiong PJ Coombs SR Martin J Liu H XiaoJohn Mccauley[...]Philip Walker PJ Collins Y Kawaoka JJ SkehelSteve Gamblin Nature Published 1 January 2013 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyFull details
Receptor binding by an H7N9 influenza virus from humans Authors (11) Xiaoli Xiong Stephen R Martin Lesley F Haire Stephen A Wharton Rodney S Daniels Michael S BennettJohn Mccauley Patrick J CollinsPhilip Walker John J SkehelSteve Gamblin Nature Published 1 January 2013 Crick labs/ facilitiesNicola LewisSteve GamblinWorldwide Influenza CentreStructural BiologyFull details
A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses Authors (17) Hongxing Hu Jarrod Voss Guoliang Zhang Philippi Buchy Teng Zuo Lulan Wang[...] Linqi Zhang Vincent Deubel Boping Zhou John J Skehel Paul Zhou Journal of Virology Published 11 January 2012 Crick labsSteve GamblinFull details