Publications

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

Authors (15)

Anna Laddach
Song Hui Chng
Reena Lasrado
Franze Progatzky
Michael Shapiro
Alek Erickson
[...]
Jens Kleinjung
Stefan Boeing
Sila Ultanir
Igor Adameyko
Vassilis Pachnis

Nature Communications

Published 22 September 2023

Crick labs/ facilities

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IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis

Authors (15)

Miguel Munoz-Ruiz
Miriam Llorian Sopena
Rocco D'Antuono
Anna Pavlova
Anna Maria Mavrigiannaki
Duncan McKenzie
[...]
Daniel Davies
Mariam Jamal-Hanjani
Anett Jandke
Dmitry S Ushakov
Adrian Hayday

Journal of Allergy and Clinical Immunology

Published 1 December 2023

Crick labs/ facilities

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MTG8 interacts with LHX6 to specify cortical interneuron subtype identity

Authors (11)

Zeinab Asgarian
Marcio Guiomar Oliveira
Agata Stryjewska
Ioannis Maragkos
Anna Noren Rubin
Lorenza Magno
Vassilis Pachnis
Mohammadmersad Ghorbani
Scott Wayne Hiebert
Myrto Denaxa
Nicoletta Kessaris

Nature Communications

Published 5 September 2022

Crick labs

Vassilis Pachnis

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Multiple roles of Ret signalling during enteric neurogenesis

Authors (5)

Dipa Natarajan
Conor McCann
Justine Dattani
Vassilis Pachnis
Nikhil Thapar

Frontiers in Molecular Neuroscience

Published 27 May 2022

Crick labs/ facilities

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Regulation of intestinal immunity and tissue repair by enteric glia

Authors (18)

Franze Progatzky
Michael Shapiro
Song Hui Chng
Bethania Garcia-Cassani
Cajsa Classon
Selin Sevgi
[...]
Lewis J Entwistle
Alejandro Suárez-Bonnet
Mark Wilson
Brigitta Stockinger
Vassilis Pachnis

Nature

Published 20 October 2021

Crick labs/ facilities

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Enteric glia as a source of neural progenitors in adult zebrafish

Authors (13)

eLife

Published 27 August 2020

Crick labs/ facilities

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Neuronal programming by microbiota regulates intestinal physiology

Authors (18)

Yuuki Obata
Alvaro Castano Medina
Stefan Boeing
Ana Carina Bon Frauches Oliveira
Candice Fung
Todd Fallesen
[...]
Pieter Vanden Berghe
Andrew J Murray
Brigitta Stockinger
Andrew J Macpherson
Vassilis Pachnis

Nature

Published 13 February 2020

Crick labs/ facilities

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Structurally defined signaling in neuro-glia units in the enteric nervous system

Authors (8)

Werend Boesmans
Marlene M Hao
Candice Fung
Zhiling Li
Chris Van den Haute
Jan Tack
Vassilis Pachnis
Pieter Vanden Berghe

Glia

Published 1 June 2019

Crick labs

Vassilis Pachnis

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Modulation of apoptosis controls inhibitory interneuron number in the cortex

Authors (7)

Myrto Denaxa
Guilherme Neves
Adam Rabinowitz
Sarah Kemlo
Petros Liodis
Juan Burrone
Vassilis Pachnis

Cell Reports

Published 13 February 2018

Crick labs/ facilities

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Transcription and signaling regulators in developing neuronal subtypes of mouse and human enteric nervous system

Authors (9)

Fatima Memic
Viktoria Knoflach
Khomgrit Morarach
Rebecca Sadler
Catia Laranjeira
Jens Hjerling-Leffler
Erik Sundström
Vassilis Pachnis
Ulrika Marklund

Gastroenterology

Published 12 October 2017

Crick labs

Vassilis Pachnis

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Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep

Authors (15)

Kai Liu
Juhyun Kim
Dong Won Kim
Yi Stephanie Zhang
Hechen Bao
Myrto Denaxa
[...]
Vassilis Pachnis
Samer Hattar
Juan Song
Solange P Brown
Seth Blackshaw

Nature

Published 31 August 2017

Crick labs

Vassilis Pachnis

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Lineage-dependent spatial and functional organization of the mammalian enteric nervous system

Authors (12)

Reena Lasrado
Werend Boesmans
Jens Kleinjung
Carmen Pin
Donald Bell
Leena Bhaw
[...]
Hui Zong
Liqun Luo
Hans Clevers
Pieter Vanden Berghe
Vassilis Pachnis

Science

Published 19 May 2017

Crick labs/ facilities

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A novel zebrafish ret heterozygous model of Hirschsprung disease identifies a functional role for mapk10 as a modifier of enteric nervous system phenotype severity

Authors (6)

Tiffany Heanue
Werend Boesmans
Donald Bell
Koichi Kawakami
Pieter Vanden Berghe
Vassilis Pachnis

PLOS Genetics

Published 30 November 2016

Crick labs/ facilities

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Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis

Authors (3)

Chrysoula Konstantinidou
Stavros Taraviras
Vassilis Pachnis

BMC Biology

Published 26 October 2016

Crick labs

Vassilis Pachnis

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Analysis of neural crest-derived clones reveals novel aspects of facial development

Authors (21)

Marketa Kaucka
Evgeny Ivashkin
Daniel Gyllborg
Tomas Zikmund
Marketa Tesarova
Jozef Kaiser
[...]
Ueli Suter
Andrei S Chagin
Kaj Fried
Andreas Hellander
Igor Adameyko

Science advances

Published 3 August 2016

Crick labs

Vassilis Pachnis

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Ascl1 is required for the development of specific neuronal subtypes in the enteric nervous system

Authors (8)

Fatima Memic
Viktoria Knoflach
Rebecca Sadler
Gunilla Tegerstedt
Erik Sundström
Francois Guillemot
Vassilis Pachnis
Ulrika Marklund

Journal of Neuroscience

Published 13 April 2016

Crick labs

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Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis

Authors (7)

Athanasia Stathopoulou
Dipa Natarajan
Pinelopi Nikolopoulou
Alexandra L Patmanidi
Zoi Lygerou
Vassilis Pachnis
Stavros Taraviras

Developmental Biology

Published 15 January 2016

Crick labs

Vassilis Pachnis

Full details

The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system

Authors (8)

Panagiotis S Kabouridis
Reena Lasrado
Sarah Mccallum
Song Hui Chng
Hugo J Snippert
Hans Clevers
Sven Pettersson
Vassilis Pachnis

Gut Microbes

Published 4 January 2016

Crick labs

Vassilis Pachnis

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Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo

Authors (11)

S Eldridge
G Nalesso
H Ismail
K Vicente-Greco
P Kabouridis
M Ramachandran
A Niemeier
J Herz
C Pitzalis
M Perretti
F Dell'Accio

Annals of the Rheumatic Diseases

Published 1 June 2016

Crick labs

Vassilis Pachnis

Full details

Lhx8 regulates primordial follicle activation and postnatal folliculogenesis

Authors (8)

Yu Ren
Hitomi Suzuki
Krishna Jagarlamudi
Kayla Golnoski
Megan McGuire
Rita Lopes
Vassilis Pachnis
Aleksandar Rajkovic

BMC Biology

Published 16 June 2015

Crick labs

Vassilis Pachnis

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A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis

MTG8 interacts with LHX6 to specify cortical interneuron subtype identity

Multiple roles of Ret signalling during enteric neurogenesis

Regulation of intestinal immunity and tissue repair by enteric glia

Enteric glia as a source of neural progenitors in adult zebrafish

Neuronal programming by microbiota regulates intestinal physiology

Structurally defined signaling in neuro-glia units in the enteric nervous system

Modulation of apoptosis controls inhibitory interneuron number in the cortex

Transcription and signaling regulators in developing neuronal subtypes of mouse and human enteric nervous system

Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep

Lineage-dependent spatial and functional organization of the mammalian enteric nervous system

A novel zebrafish ret heterozygous model of Hirschsprung disease identifies a functional role for mapk10 as a modifier of enteric nervous system phenotype severity

Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis

Analysis of neural crest-derived clones reveals novel aspects of facial development

Ascl1 is required for the development of specific neuronal subtypes in the enteric nervous system

Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis

The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system

Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo

Lhx8 regulates primordial follicle activation and postnatal folliculogenesis

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