Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Venizelos Papayannopoulos Papayannopoulos lab Antimicrobial Defense Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies PublicationsYear published2023 (4)2022 (5)2021 (1)2020 (6)2019 (3)2018 (3)2017 (3)2015 (3)2014 (6)2013 (1)2011 (2)2010 (1) Facet Year publishedResearch topicsInfectious Disease (28)Immunology (27)Genetics & Genomics (9)Model Organisms (9)Tumour Biology (9)Chemical Biology & High Throughput (8)Computational & Systems Biology (8)Human Biology & Physiology (8)Genome Integrity & Repair (7)Cell Biology (6)Stem Cells (5)Metabolism (4)Signalling & Oncogenes (3)Synthetic Biology (3)Cell Cycle & Chromosomes (2)Developmental Biology (2)Gene Expression (2)Imaging (2)Neurosciences (2)Structural Biology & Biophysics (2)Biochemistry & Proteomics (1)Microfabrication & Bioengineering (1) Facet Research topicsCrick/Pre-CrickCrick publications (34)Pre-Crick publications (3) Facet Crick/Pre-CrickPublication typeJournal article (37)Primary research (23)Commentary (5)Review (5)Method (1) Facet Publication typeJournalImmunity (5)Nature Communications (3)Blood (2)Cell Host and Microbe (2)Cell Reports (2)Nature Immunology (2)Stem Cell Reports (2)Breast Cancer Research (1)Cardiovascular Research (1)Cell Stem Cell (1)Current Biology (1)EMBO Reports (1)Frontiers in Immunology (1)Journal of Cell Biology (1)Journal of Clinical Investigation (1)Journal of Experimental Medicine (1)Nature Biotechnology (1)Nature Medicine (1)Nature Reviews Immunology (1)PLOS Biology (1)PLOS ONE (1)Science (1)Science Immunology (1)Seminars in Immunopathology (1)The EMBO Journal (1)The Lancet (1) Facet Journal Publications Displaying 1 - 20 of 38Last updated : 29 March 2024 03:04 Circulating neutrophils from patients with early breast cancer have distinct subtype-dependent phenotypes Authors (9)Anisha Ramessur Bana AmbasagerIker Valle AramburuFrederick Peakman Kelly Gleason Christoph LehmannVenizelos Papayannopoulos Raoul Charles CoombesIlaria Malanchi Breast Cancer Research Published 19 October 2023 Crick labs/ facilitiesVenizelos PapayannopoulosIlaria MalanchiFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details NET histones inflame periodontitis Authors (1)Venizelos Papayannopoulos Journal of Experimental Medicine Published 4 September 2023 Crick labsVenizelos PapayannopoulosFull details Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Authors (22)Hector Huerga EncaboIker Valle AramburuManuel Garcia AlbornozMarion Piganeau Henry Wood Anna Song[...] Daniel H Wiseman Kiran Batta Rajeev GuptaVenizelos PapayannopoulosDominique Bonnet Cell Stem Cell Published 1 June 2023 Crick labs/ facilitiesCaetano Reis e SousaVenizelos PapayannopoulosDominique BonnetLight MicroscopyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Human endogenous retrovirus onco-exaptation counters cancer cell senescence through calbindin Authors (14)Jan AttigJudith PapeLaura DoglioAnastasiya KazachenkaEleonora OttinaGeorge Young[...]Nikhil Faulkner William BollandVenizelos PapayannopoulosCharles SwantonGeorge Kassiotis Journal of Clinical Investigation Published 17 July 2023 Crick labs/ facilitiesCharles SwantonVenizelos PapayannopoulosGeorge KassiotisBioinformatics and BiostatisticsScientific computingLight MicroscopyIn Vivo ImagingHigh Throughput ScreeningFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia Authors (22) Iker Valle Aramburu Dennis HovingSpyros Vernardis Martha CF Tin Marianna IoannouMia Temkin[...] Sascha David Christian Bode Florian KurthMarkus RalserVenizelos Papayannopoulos Immunity Published 13 December 2022 Crick labsMarkus RalserVenizelos PapayannopoulosFull details Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening Authors (16) Marianna Ioannou Dennis Hoving Iker Valle AramburuMia Temkin Nathalia M De Vasconcelos Theodora Dorita Tsourouktsoglou[...]Markus Ralser Sascha David Klaus Stahl Christian BodeVenizelos Papayannopoulos Nature Communications Published 9 August 2022 Crick labs/ facilitiesMarkus RalserVenizelos PapayannopoulosBioinformatics and BiostatisticsAdvanced SequencingFull details The roles of neutrophils linking periodontitis and atherosclerotic cardiovascular diseases Authors (6) Rizky A Irwandi Scott T Chiesa George HajishengallisVenizelos Papayannopoulos John E Deanfield Francesco D'Aiuto Frontiers in Immunology Published 7 July 2022 Crick labsVenizelos PapayannopoulosFull details Actin powers the neutrophil traps Authors (1)Venizelos Papayannopoulos Blood Published 26 May 2022 Crick labsVenizelos PapayannopoulosFull details Neutrophil extracellular traps: from physiology to pathology Authors (6) Andres Hidalgo Peter Libby Oliver Soehnlein Iker Valle AramburuVenizelos Papayannopoulos Carlos Silvestre-Roig Cardiovascular Research Published 1 September 2022 Crick labsVenizelos PapayannopoulosFull details Human erythroid progenitors are directly infected by SARS-CoV-2: Implications for emerging erythropoiesis in severe COVID-19 patients Authors (11)Hector Huerga EncaboWilliam GreyManuel Garcia Albornoz Henry WoodRachel Ulferts Iker Valle Aramburu Austin G Kulasekararaj Ghulam MuftiVenizelos PapayannopoulosRupert BealeDominique Bonnet Stem Cell Reports Published 9 March 2021 Crick labs/ facilitiesVenizelos PapayannopoulosDominique BonnetRupert BealeFlow CytometryFull details Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis Authors (19)Lucia Moreira-Teixeira Philippa J StimpsonEvangelos Stavropoulos Sabelo Hadebe Probir Chakravarty Marianna Ioannou[...] Paula Rodríguez-Martínez Cristina Vilaplana Margarida SaraivaVenizelos PapayannopoulosAnne O'Garra Nature Communications Published 4 November 2020 Crick labs/ facilitiesVenizelos PapayannopoulosAnne O’GarraExperimental HistopathologyBioinformatics and BiostatisticsBiological Research FacilityAdvanced SequencingFull details LRRK2 activation controls the repair of damaged endomembranes in macrophages Authors (8)Susanne Herbst Philip Campbell John HarveyElliott BernardVenizelos Papayannopoulos Nicholas W Wood Huw R MorrisMaximiliano Gutierrez The EMBO Journal Published 15 September 2020 Crick labs/ facilitiesVenizelos PapayannopoulosMaximiliano GutierrezLight MicroscopyFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...]Sophie Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details Histones, DNA, and citrullination promote neutrophil extracellular trap inflammation by regulating the localization and activation of TLR4 Authors (6) Theodora-Dorita Tsourouktsoglou Annika Warnatsch Marianna Ioannou Dennis HovingQian WangVenizelos Papayannopoulos Cell Reports Published 5 May 2020 Crick labsVenizelos PapayannopoulosFull details Hookworms evade host immunity by secreting a deoxyribonuclease to degrade neutrophil extracellular traps Authors (19) Tiffany Bouchery Mati Moyat Javier Sotillo Solomon Silverstein Beatrice Volpe Gillian Coakley[...] Paul Giacomin Graham Le GrosVenizelos Papayannopoulos Alex Loukas Nicola L Harris Cell Host and Microbe Published 12 February 2020 Crick labsVenizelos PapayannopoulosFull details Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases Authors (35)Akul SinghaniaChristine GrahamLeona GabrysovaLucia Moreira-TeixeiraEvangelos Stavropoulos Jonathan M Pitt[...]Venizelos PapayannopoulosAndreas Wack Jacques F Banchereau Virginia M PascualAnne O'Garra Nature Communications Published 28 June 2019 Crick labs/ facilitiesAndreas WackVenizelos PapayannopoulosAnne O’GarraJean LanghorneEva FrickelBioinformatics and BiostatisticsAdvanced SequencingFlow CytometryExperimental HistopathologyBiological Research FacilityFull details IL-23-producing IL-10Rα-deficient gut macrophages elicit an IL-22-driven proinflammatory epithelial cell response Authors (14) Biana Bernshtein Caterina Curato Marianna Ioannou Christoph A Thaiss Mor Gross-Vered Masha Kolesnikov[...] Alon Harmelin Eran Elinav Paresh ThakkerVenizelos Papayannopoulos Steffen Jung Science Immunology Published 14 June 2019 Crick labsVenizelos PapayannopoulosFull details Neutrophils facing biofilms: The battle of the barriers Authors (1)Venizelos Papayannopoulos Cell Host and Microbe Published 10 April 2019 Crick labsVenizelos PapayannopoulosFull details Neutrophils stepping through (to the other side) Authors (1)Venizelos Papayannopoulos Immunity Published 18 December 2018 Crick labsVenizelos PapayannopoulosFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Circulating neutrophils from patients with early breast cancer have distinct subtype-dependent phenotypes Authors (9)Anisha Ramessur Bana AmbasagerIker Valle AramburuFrederick Peakman Kelly Gleason Christoph LehmannVenizelos Papayannopoulos Raoul Charles CoombesIlaria Malanchi Breast Cancer Research Published 19 October 2023 Crick labs/ facilitiesVenizelos PapayannopoulosIlaria MalanchiFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
NET histones inflame periodontitis Authors (1)Venizelos Papayannopoulos Journal of Experimental Medicine Published 4 September 2023 Crick labsVenizelos PapayannopoulosFull details
Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Authors (22)Hector Huerga EncaboIker Valle AramburuManuel Garcia AlbornozMarion Piganeau Henry Wood Anna Song[...] Daniel H Wiseman Kiran Batta Rajeev GuptaVenizelos PapayannopoulosDominique Bonnet Cell Stem Cell Published 1 June 2023 Crick labs/ facilitiesCaetano Reis e SousaVenizelos PapayannopoulosDominique BonnetLight MicroscopyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Human endogenous retrovirus onco-exaptation counters cancer cell senescence through calbindin Authors (14)Jan AttigJudith PapeLaura DoglioAnastasiya KazachenkaEleonora OttinaGeorge Young[...]Nikhil Faulkner William BollandVenizelos PapayannopoulosCharles SwantonGeorge Kassiotis Journal of Clinical Investigation Published 17 July 2023 Crick labs/ facilitiesCharles SwantonVenizelos PapayannopoulosGeorge KassiotisBioinformatics and BiostatisticsScientific computingLight MicroscopyIn Vivo ImagingHigh Throughput ScreeningFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia Authors (22) Iker Valle Aramburu Dennis HovingSpyros Vernardis Martha CF Tin Marianna IoannouMia Temkin[...] Sascha David Christian Bode Florian KurthMarkus RalserVenizelos Papayannopoulos Immunity Published 13 December 2022 Crick labsMarkus RalserVenizelos PapayannopoulosFull details
Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening Authors (16) Marianna Ioannou Dennis Hoving Iker Valle AramburuMia Temkin Nathalia M De Vasconcelos Theodora Dorita Tsourouktsoglou[...]Markus Ralser Sascha David Klaus Stahl Christian BodeVenizelos Papayannopoulos Nature Communications Published 9 August 2022 Crick labs/ facilitiesMarkus RalserVenizelos PapayannopoulosBioinformatics and BiostatisticsAdvanced SequencingFull details
The roles of neutrophils linking periodontitis and atherosclerotic cardiovascular diseases Authors (6) Rizky A Irwandi Scott T Chiesa George HajishengallisVenizelos Papayannopoulos John E Deanfield Francesco D'Aiuto Frontiers in Immunology Published 7 July 2022 Crick labsVenizelos PapayannopoulosFull details
Actin powers the neutrophil traps Authors (1)Venizelos Papayannopoulos Blood Published 26 May 2022 Crick labsVenizelos PapayannopoulosFull details
Neutrophil extracellular traps: from physiology to pathology Authors (6) Andres Hidalgo Peter Libby Oliver Soehnlein Iker Valle AramburuVenizelos Papayannopoulos Carlos Silvestre-Roig Cardiovascular Research Published 1 September 2022 Crick labsVenizelos PapayannopoulosFull details
Human erythroid progenitors are directly infected by SARS-CoV-2: Implications for emerging erythropoiesis in severe COVID-19 patients Authors (11)Hector Huerga EncaboWilliam GreyManuel Garcia Albornoz Henry WoodRachel Ulferts Iker Valle Aramburu Austin G Kulasekararaj Ghulam MuftiVenizelos PapayannopoulosRupert BealeDominique Bonnet Stem Cell Reports Published 9 March 2021 Crick labs/ facilitiesVenizelos PapayannopoulosDominique BonnetRupert BealeFlow CytometryFull details
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis Authors (19)Lucia Moreira-Teixeira Philippa J StimpsonEvangelos Stavropoulos Sabelo Hadebe Probir Chakravarty Marianna Ioannou[...] Paula Rodríguez-Martínez Cristina Vilaplana Margarida SaraivaVenizelos PapayannopoulosAnne O'Garra Nature Communications Published 4 November 2020 Crick labs/ facilitiesVenizelos PapayannopoulosAnne O’GarraExperimental HistopathologyBioinformatics and BiostatisticsBiological Research FacilityAdvanced SequencingFull details
LRRK2 activation controls the repair of damaged endomembranes in macrophages Authors (8)Susanne Herbst Philip Campbell John HarveyElliott BernardVenizelos Papayannopoulos Nicholas W Wood Huw R MorrisMaximiliano Gutierrez The EMBO Journal Published 15 September 2020 Crick labs/ facilitiesVenizelos PapayannopoulosMaximiliano GutierrezLight MicroscopyFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...]Sophie Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details
Histones, DNA, and citrullination promote neutrophil extracellular trap inflammation by regulating the localization and activation of TLR4 Authors (6) Theodora-Dorita Tsourouktsoglou Annika Warnatsch Marianna Ioannou Dennis HovingQian WangVenizelos Papayannopoulos Cell Reports Published 5 May 2020 Crick labsVenizelos PapayannopoulosFull details
Hookworms evade host immunity by secreting a deoxyribonuclease to degrade neutrophil extracellular traps Authors (19) Tiffany Bouchery Mati Moyat Javier Sotillo Solomon Silverstein Beatrice Volpe Gillian Coakley[...] Paul Giacomin Graham Le GrosVenizelos Papayannopoulos Alex Loukas Nicola L Harris Cell Host and Microbe Published 12 February 2020 Crick labsVenizelos PapayannopoulosFull details
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases Authors (35)Akul SinghaniaChristine GrahamLeona GabrysovaLucia Moreira-TeixeiraEvangelos Stavropoulos Jonathan M Pitt[...]Venizelos PapayannopoulosAndreas Wack Jacques F Banchereau Virginia M PascualAnne O'Garra Nature Communications Published 28 June 2019 Crick labs/ facilitiesAndreas WackVenizelos PapayannopoulosAnne O’GarraJean LanghorneEva FrickelBioinformatics and BiostatisticsAdvanced SequencingFlow CytometryExperimental HistopathologyBiological Research FacilityFull details
IL-23-producing IL-10Rα-deficient gut macrophages elicit an IL-22-driven proinflammatory epithelial cell response Authors (14) Biana Bernshtein Caterina Curato Marianna Ioannou Christoph A Thaiss Mor Gross-Vered Masha Kolesnikov[...] Alon Harmelin Eran Elinav Paresh ThakkerVenizelos Papayannopoulos Steffen Jung Science Immunology Published 14 June 2019 Crick labsVenizelos PapayannopoulosFull details
Neutrophils facing biofilms: The battle of the barriers Authors (1)Venizelos Papayannopoulos Cell Host and Microbe Published 10 April 2019 Crick labsVenizelos PapayannopoulosFull details
Neutrophils stepping through (to the other side) Authors (1)Venizelos Papayannopoulos Immunity Published 18 December 2018 Crick labsVenizelos PapayannopoulosFull details