Publications

Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome

Authors (20)

Science Translational Medicine

Published 24 January 2024

Crick labs/ facilities

Full details

T cell migration requires ion and water influx to regulate actin polymerization

Authors (13)

Nature Communications

Published 6 December 2023

Crick labs/ facilities

Full details

Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome

Authors (13)

ME Serrano
E Kim
Bernard Siow
D Ma
L Rojo
C Simmons
[...]
N Singh
A Strydom
EMC Fisher
Victor Tybulewicz
D Cash

Neurobiology of Disease

Published 1 November 2023

Crick labs/ facilities

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Affordable optical clearing and immunolabelling in mouse brain slices

Authors (8)

Phillip M Muza
Marta Pérez
Suzanna Noy
Miyu Kurosawa
Loukia Katsouri
Victor Tybulewicz
Elizabeth MC Fisher
Steven J West

BMC Research Notes

Published 30 September 2023

Crick labs

Victor Tybulewicz

Full details

Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes

Authors (10)

Yushi Redhead
Dorota Gibbins
Eva Lana-Elola
Sheona Watson-Scales
Lisa Dobson
Matthias Krause
Karen J Liu
Elizabeth MC Fisher
Jeremy BA Green
Victor Tybulewicz

Development

Published 15 April 2023

Crick labs

Victor Tybulewicz

Full details

Genetic dissection of triplicated chromosome 21 orthologs yields varying skeletal traits in Down syndrome model mice

Authors (11)

Kourtney Sloan
Jared Thomas
Matthew Blackwell
Deanna Voisard
Eva Lana-Elola
Sheona Watson-Scales
Daniel L Roper
Joseph M Wallace
Elizabeth MC Fisher
Victor Tybulewicz
Randall J Roper

Disease Models and Mechanisms

Published 1 April 2023

Crick labs

Victor Tybulewicz

Full details

Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture

Authors (13)

PM Muza
D Bush
M Pérez-González
I Zouhair
K Cleverley
M Llorian-Sopena
[...]
M Good
Victor Tybulewicz
MC Walker
EMC Fisher
P Chang

iScience

Published 17 February 2023

Crick labs/ facilities

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B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice

Authors (11)

Darryl Hayward
Lesley Vanes
Stefanie Wissmann
Sujana Sivapatham
Harald Hartweger
Joshua Biggs O'May
Leon De Boer
Richard Mitter
Robert Koechl
Jens V Stein
Victor Tybulewicz

Journal of Experimental Medicine

Published 6 March 2023

Crick labs/ facilities

Full details

Antidepressants cheer up hepatic B1 B cells: Hope for the treatment of autoimmune liver diseases?

Authors (2)

Frontiers in Immunology

Published 17 January 2023

Crick labs

Victor Tybulewicz

Full details

Genetic mapping of APP and amyloid-β biology modulation by trisomy 21

Authors (17)

Paige Mumford
Justin Tosh
Silvia Anderle
Eleni Gkanatsiou Wikberg
Gloria Lau
Sue Noy
[...]
Kaj Blennow
Henrik Zetterberg
Victor Tybulewicz
Elizabeth MC Fisher
Frances K Wiseman

The Journal of Neuroscience

Published 17 August 2022

Crick labs

Victor Tybulewicz

Full details

Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome

Authors (7)

Claudia Cannavo
Karen Cleverley
Cheryl Maduro
Paige Mumford
Dale Moulding
Elizabeth MC Fisher
Frances K Wiseman

PLOS ONE

Published 11 May 2022

Crick labs

Victor Tybulewicz

Full details

Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift

Authors (21)

Yang Zhang
Laura Garcia-Ibanez
Carolin Ulbricht
Laurence SC Lok
Jeremy A Pike
Jennifer Mueller-Winkler
[...]
Victor Tybulewicz
Antal Rot
Anja E Hauser
Menna R Clatworthy
Kai-Michael Toellner

Nature Communications

Published 5 May 2022

Crick labs

Victor Tybulewicz

Full details

Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration

Authors (11)

Emilie J Cosway
Andrea J White
Sonia M Parnell
Edina Schweighoffer
Helen E Jolin
Andrea Bacon
Hans-Reimer Rodewald
Victor Tybulewicz
Andrew NJ McKenzie
William E Jenkinson
Graham Anderson

Science Immunology

Published 1 March 2022

Crick labs

Victor Tybulewicz

Full details

Mouse models of aneuploidy to understand chromosome disorders

Authors (3)

Justin Tosh
Victor Tybulewicz
Elizabeth MC Fisher

Mammalian Genome

Published 1 March 2022

Crick labs

Victor Tybulewicz

Full details

A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome

Authors (10)

Nicolas Toussaint
Yushi Redhead
Marta Vidal-García
Lucas Lo Vercio
Wei Liu
Elizabeth MC Fisher
Benedikt Hallgrímsson
Victor Tybulewicz
Julia A Schnabel
Jeremy BA Green

Development

Published 15 September 2021

Crick labs

Victor Tybulewicz

Full details

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes

Authors (26)

Eva Lana-Elola
Heather Cater
Sheona Watson-Scales
Simon Greenaway
Jennifer Mueller-Winkler
Dorota Gibbins
[...]
Michelle Simon
Ann-Marie Mallon
Sara Wells
Elizabeth MC Fisher
Victor Tybulewicz

Disease Models and Mechanisms

Published 1 October 2021

Crick labs/ facilities

Full details

BAFF signaling in health and disease

Authors (2)

Current Opinion in Immunology

Published 1 August 2021

Crick labs

Victor Tybulewicz

Full details

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

Authors (8)

Lindsey Mayes-Hopfinger
Aura Enache
Jian Xie
Chou-Long Huang
Robert Koechl
Victor Tybulewicz
Teresa Fernandes-Alnemri
Emad S Alnemri

Nature Communications

Published 27 July 2021

Crick labs

Victor Tybulewicz

Full details

Maternal iron deficiency perturbs embryonic cardiovascular development in mice

Authors (22)

Jacinta I Kalisch-Smith
Nikita Ved
Dorota Szumska
Jacob Munro
Michael Troup
Shelley E Harris
[...]
Timothy J Mohun
Samira Lakhal-Littleton
Sarah De Val
Eleni Giannoulatou
Duncan B Sparrow

Nature Communications

Published 8 June 2021

Crick labs/ facilities

Full details

Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models

Authors (13)

Justin L Tosh
Elena R Rhymes
Paige Mumford
Heather T Whittaker
Laura J Pulford
Sue J Noy
[...]
Matthew C Walker
Victor LJ Tybulewicz
Rob C Wykes
Elizabeth MC Fisher
Frances K Wiseman

Scientific Reports

Published 11 March 2021

Crick labs

Victor Tybulewicz

Full details

Research case studies

Postdoctoral clinical fellows

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Immune Cell Biology Laboratory & Down Syndrome Laboratory
: Publications

Lab content

Publications

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Publication type

Journal

Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome

T cell migration requires ion and water influx to regulate actin polymerization

Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome

Affordable optical clearing and immunolabelling in mouse brain slices

Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes

Genetic dissection of triplicated chromosome 21 orthologs yields varying skeletal traits in Down syndrome model mice

Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture

B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice

Antidepressants cheer up hepatic B1 B cells: Hope for the treatment of autoimmune liver diseases?

Genetic mapping of APP and amyloid-β biology modulation by trisomy 21

Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome

Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift

Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration

Mouse models of aneuploidy to understand chromosome disorders

A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes

BAFF signaling in health and disease

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

Maternal iron deficiency perturbs embryonic cardiovascular development in mice

Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models

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Postdoctoral clinical fellows

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Research topics

Publication type

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