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Breadcrumb Victor Tybulewicz Tybulewicz lab Immune Cell Biology Laboratory & Down Syndrome Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Image taken by Rifdat Aoidi using microscopes in the Light Microscopy STP. Toggle to view hero caption PublicationsYear published2024 (1)2023 (2)2021 (1)2020 (3)2019 (1) Facet Year publishedResearch topicsCell Biology (8)Developmental Biology (8)Human Biology & Physiology (8)Immunology (8)Model Organisms (8)Signalling & Oncogenes (8)Tumour Biology (7)Chemical Biology & High Throughput (6)Genetics & Genomics (6)Genome Integrity & Repair (6)Infectious Disease (3)Biochemistry & Proteomics (2)Gene Expression (2)Neurosciences (2)Synthetic Biology (2)Metabolism (1) (-)Computational & Systems Biology (8) Facet Research topicsPublication typeJournal article (8)Primary research (8) Facet Publication typeJournalJournal of Experimental Medicine (2)Nature Communications (2)Disease Models and Mechanisms (1)eLife (1)Science (1)Science Translational Medicine (1) Facet Journal Publications Displaying 1 - 8 of 8Last updated : 29 March 2024 03:18 Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20)Eva Lana-ElolaRifdat Aoidi Miriam LlorianDorota GibbinsCallan BuechsenschuetzClaudio Bussi[...] Laurent MeijerBram SnijdersMaximiliano Gutierrez Elizabeth MC FisherVictor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilitiesVictor TybulewiczMaximiliano GutierrezProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsFull details T cell migration requires ion and water influx to regulate actin polymerization Authors (13)Leon De BoerLesley Vanes Serena MelgratiJoshua Biggs O'MayDarryl HaywardPaul Driscoll[...] Renata Magueta Alexander MorrellJames MacraeRobert KoechlVictor Tybulewicz Nature Communications Published 6 December 2023 Crick labs/ facilitiesVictor TybulewiczMetabolomicsLight MicroscopyFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice Authors (11)Darryl HaywardLesley Vanes Stefanie Wissmann Sujana Sivapatham Harald HartwegerJoshua Biggs O'MayLeon De Boer Richard MitterRobert Koechl Jens V SteinVictor Tybulewicz Journal of Experimental Medicine Published 6 March 2023 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsMedia PreparationLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes Authors (26)Eva Lana-Elola Heather Cater Sheona Watson-Scales Simon GreenawayJennifer Mueller-WinklerDorota Gibbins[...] Michelle Simon Ann-Marie Mallon Sara Wells Elizabeth MC FisherVictor Tybulewicz Disease Models and Mechanisms Published 1 October 2021 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival Authors (8)Jennifer Mueller-Winkler Richard MitterJulie RappeLesley VanesEdina SchweighofferHamid MohammadiAndreas WackVictor Tybulewicz Journal of Experimental Medicine Published 1 February 2021 Crick labs/ facilitiesAndreas WackVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Critical role of WNK1 in MYC-dependent early mouse thymocyte development Authors (10)Robert KoechlLesley Vanes Miriam Llorian Sopena Probir Chakravarty Harald Hartweger Kathryn Fountain Andrea White Jennifer Cowan Graham AndersonVictor Tybulewicz eLife Published 14 October 2020 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryCell ServicesBiological Research FacilityAdvanced SequencingFull details Species-specific pace of development is associated with differences in protein stability Authors (11)Teresa Rayon AlonsoDespina Stamataki Ruben Perez-CarrascoLorena Garcia-Perez Christopher BarringtonManuela MelchiondaKatherine Exelby Jorge LazaroVictor Tybulewicz Elizabeth MC FisherJames Briscoe Science Published 18 September 2020 Crick labs/ facilitiesVictor TybulewiczJames BriscoeBioinformatics and BiostatisticsFull details Gene expression dysregulation domains are not a specific feature of Down syndrome Authors (12) Helena Ahlfors Nnneka Anyanwu Edvinas Pakanavicius Natalia DinischiotuEva Lana-Elola Sheona Watson-Scales[...] Frances WisemanJames Briscoe Karen Page Elizabeth MC FisherVictor Tybulewicz Nature Communications Published 6 June 2019 Crick labs/ facilitiesVictor TybulewiczJames BriscoeGenetic Modification ServiceBiological Research FacilityAdvanced SequencingFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20)Eva Lana-ElolaRifdat Aoidi Miriam LlorianDorota GibbinsCallan BuechsenschuetzClaudio Bussi[...] Laurent MeijerBram SnijdersMaximiliano Gutierrez Elizabeth MC FisherVictor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilitiesVictor TybulewiczMaximiliano GutierrezProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
T cell migration requires ion and water influx to regulate actin polymerization Authors (13)Leon De BoerLesley Vanes Serena MelgratiJoshua Biggs O'MayDarryl HaywardPaul Driscoll[...] Renata Magueta Alexander MorrellJames MacraeRobert KoechlVictor Tybulewicz Nature Communications Published 6 December 2023 Crick labs/ facilitiesVictor TybulewiczMetabolomicsLight MicroscopyFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice Authors (11)Darryl HaywardLesley Vanes Stefanie Wissmann Sujana Sivapatham Harald HartwegerJoshua Biggs O'MayLeon De Boer Richard MitterRobert Koechl Jens V SteinVictor Tybulewicz Journal of Experimental Medicine Published 6 March 2023 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsMedia PreparationLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes Authors (26)Eva Lana-Elola Heather Cater Sheona Watson-Scales Simon GreenawayJennifer Mueller-WinklerDorota Gibbins[...] Michelle Simon Ann-Marie Mallon Sara Wells Elizabeth MC FisherVictor Tybulewicz Disease Models and Mechanisms Published 1 October 2021 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival Authors (8)Jennifer Mueller-Winkler Richard MitterJulie RappeLesley VanesEdina SchweighofferHamid MohammadiAndreas WackVictor Tybulewicz Journal of Experimental Medicine Published 1 February 2021 Crick labs/ facilitiesAndreas WackVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
Critical role of WNK1 in MYC-dependent early mouse thymocyte development Authors (10)Robert KoechlLesley Vanes Miriam Llorian Sopena Probir Chakravarty Harald Hartweger Kathryn Fountain Andrea White Jennifer Cowan Graham AndersonVictor Tybulewicz eLife Published 14 October 2020 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryCell ServicesBiological Research FacilityAdvanced SequencingFull details
Species-specific pace of development is associated with differences in protein stability Authors (11)Teresa Rayon AlonsoDespina Stamataki Ruben Perez-CarrascoLorena Garcia-Perez Christopher BarringtonManuela MelchiondaKatherine Exelby Jorge LazaroVictor Tybulewicz Elizabeth MC FisherJames Briscoe Science Published 18 September 2020 Crick labs/ facilitiesVictor TybulewiczJames BriscoeBioinformatics and BiostatisticsFull details
Gene expression dysregulation domains are not a specific feature of Down syndrome Authors (12) Helena Ahlfors Nnneka Anyanwu Edvinas Pakanavicius Natalia DinischiotuEva Lana-Elola Sheona Watson-Scales[...] Frances WisemanJames Briscoe Karen Page Elizabeth MC FisherVictor Tybulewicz Nature Communications Published 6 June 2019 Crick labs/ facilitiesVictor TybulewiczJames BriscoeGenetic Modification ServiceBiological Research FacilityAdvanced SequencingFull details