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Breadcrumb Victor Tybulewicz Tybulewicz lab Immune Cell Biology Laboratory & Down Syndrome Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Image taken by Rifdat Aoidi using microscopes in the Light Microscopy STP. Toggle to view hero caption PublicationsYear published2024 (1)2023 (8)2022 (4)2021 (7)2020 (9)2019 (4)2018 (6)2017 (5)2016 (9)2015 (4)2014 (1) Facet Year publishedResearch topicsCell Biology (58)Developmental Biology (58)Human Biology & Physiology (58)Immunology (58)Signalling & Oncogenes (58)Computational & Systems Biology (8)Genetics & Genomics (8)Tumour Biology (7)Chemical Biology & High Throughput (6)Genome Integrity & Repair (6)Imaging (4)Infectious Disease (4)Biochemistry & Proteomics (3)Gene Expression (3)Neurosciences (3)Synthetic Biology (2)Metabolism (1)Stem Cells (1) (-)Model Organisms (58) Facet Research topicsPublication typeJournal article (58)Primary research (50)Review (7)Method (1) Facet Publication typeJournalNature Communications (5)eLife (4)Journal of Experimental Medicine (4)Alzheimer's and Dementia (2)Alzheimer's Research and Therapy (2)Cell Reports (2)Development (2)Disease Models and Mechanisms (2)Neurobiology of Disease (2)PLOS Genetics (2)PLOS ONE (2)Scientific Reports (2)Blood (1)BMC Research Notes (1)Bone (1)Brain (1)Current Opinion in Cell Biology (1)Current Opinion in Immunology (1)Disease Models & Mechanisms (1)European Journal of Immunology (1)F1000Research (1)Frontiers in Immunology (1)Frontiers in Psychiatry (1)iScience (1)JAMA Neurology (1)Journal of Immunology (1)Journal of Neurodevelopmental Disorders (1)Journal of Psychopharmacology (1)Mammalian Genome (1)Molecular Psychiatry (1)Nature Immunology (1)Nature Neuroscience (1)Nature Reviews Neuroscience (1)Neurobiology of Learning and Memory (1)NeuroImage (1)Science (1)Science Immunology (1)Science Translational Medicine (1)The Journal of Neuroscience (1) Facet Journal Publications Displaying 1 - 20 of 58Last updated : 29 March 2024 03:23 Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20)Eva Lana-ElolaRifdat Aoidi Miriam LlorianDorota GibbinsCallan BuechsenschuetzClaudio Bussi[...] Laurent MeijerBram SnijdersMaximiliano Gutierrez Elizabeth MC FisherVictor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilitiesVictor TybulewiczMaximiliano GutierrezProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsFull details T cell migration requires ion and water influx to regulate actin polymerization Authors (13)Leon De BoerLesley Vanes Serena MelgratiJoshua Biggs O'MayDarryl HaywardPaul Driscoll[...] Renata Magueta Alexander MorrellJames MacraeRobert KoechlVictor Tybulewicz Nature Communications Published 6 December 2023 Crick labs/ facilitiesVictor TybulewiczMetabolomicsLight MicroscopyFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome Authors (13) ME Serrano E KimBernard Siow D Ma L Rojo C Simmons[...] N Singh A Strydom EMC FisherVictor Tybulewicz D Cash Neurobiology of Disease Published 1 November 2023 Crick labs/ facilitiesVictor TybulewiczIn Vivo ImagingBiological Research FacilityFull details Affordable optical clearing and immunolabelling in mouse brain slices Authors (8) Phillip M Muza Marta Pérez Suzanna Noy Miyu Kurosawa Loukia KatsouriVictor Tybulewicz Elizabeth MC Fisher Steven J West BMC Research Notes Published 30 September 2023 Crick labsVictor TybulewiczFull details Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes Authors (10)Yushi RedheadDorota GibbinsEva Lana-Elola Sheona Watson-Scales Lisa Dobson Matthias Krause Karen J Liu Elizabeth MC Fisher Jeremy BA GreenVictor Tybulewicz Development Published 15 April 2023 Crick labsVictor TybulewiczFull details Genetic dissection of triplicated chromosome 21 orthologs yields varying skeletal traits in Down syndrome model mice Authors (11) Kourtney Sloan Jared Thomas Matthew Blackwell Deanna VoisardEva Lana-Elola Sheona Watson-Scales Daniel L Roper Joseph M Wallace Elizabeth MC FisherVictor Tybulewicz Randall J Roper Disease Models and Mechanisms Published 1 April 2023 Crick labsVictor TybulewiczFull details Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture Authors (13) PM Muza D Bush M Pérez-González I Zouhair K Cleverley M Llorian-Sopena[...] M GoodVictor Tybulewicz MC Walker EMC Fisher P Chang iScience Published 17 February 2023 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsFull details B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice Authors (11)Darryl HaywardLesley Vanes Stefanie Wissmann Sujana Sivapatham Harald HartwegerJoshua Biggs O'MayLeon De Boer Richard MitterRobert Koechl Jens V SteinVictor Tybulewicz Journal of Experimental Medicine Published 6 March 2023 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsMedia PreparationLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details Antidepressants cheer up hepatic B1 B cells: Hope for the treatment of autoimmune liver diseases? Authors (2)Timm AmendtVictor Tybulewicz Frontiers in Immunology Published 17 January 2023 Crick labsVictor TybulewiczFull details Genetic mapping of APP and amyloid-β biology modulation by trisomy 21 Authors (17) Paige Mumford Justin Tosh Silvia Anderle Eleni Gkanatsiou Wikberg Gloria Lau Sue Noy[...] Kaj Blennow Henrik ZetterbergVictor Tybulewicz Elizabeth MC Fisher Frances K Wiseman The Journal of Neuroscience Published 17 August 2022 Crick labsVictor TybulewiczFull details Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome Authors (7) Claudia Cannavo Karen Cleverley Cheryl Maduro Paige Mumford Dale Moulding Elizabeth MC Fisher Frances K Wiseman PLOS ONE Published 11 May 2022 Crick labsVictor TybulewiczFull details Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift Authors (21) Yang Zhang Laura Garcia-Ibanez Carolin Ulbricht Laurence SC Lok Jeremy A PikeJennifer Mueller-Winkler[...]Victor Tybulewicz Antal Rot Anja E Hauser Menna R Clatworthy Kai-Michael Toellner Nature Communications Published 5 May 2022 Crick labsVictor TybulewiczFull details Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration Authors (11) Emilie J Cosway Andrea J White Sonia M ParnellEdina Schweighoffer Helen E Jolin Andrea Bacon Hans-Reimer RodewaldVictor Tybulewicz Andrew NJ McKenzie William E Jenkinson Graham Anderson Science Immunology Published 1 March 2022 Crick labsVictor TybulewiczFull details Mouse models of aneuploidy to understand chromosome disorders Authors (3)Justin ToshVictor Tybulewicz Elizabeth MC Fisher Mammalian Genome Published 1 March 2022 Crick labsVictor TybulewiczFull details A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome Authors (10) Nicolas ToussaintYushi Redhead Marta Vidal-García Lucas Lo Vercio Wei Liu Elizabeth MC Fisher Benedikt HallgrímssonVictor Tybulewicz Julia A Schnabel Jeremy BA Green Development Published 15 September 2021 Crick labsVictor TybulewiczFull details Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes Authors (26)Eva Lana-Elola Heather Cater Sheona Watson-Scales Simon GreenawayJennifer Mueller-WinklerDorota Gibbins[...] Michelle Simon Ann-Marie Mallon Sara Wells Elizabeth MC FisherVictor Tybulewicz Disease Models and Mechanisms Published 1 October 2021 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details BAFF signaling in health and disease Authors (2)Edina SchweighofferVictor Tybulewicz Current Opinion in Immunology Published 1 August 2021 Crick labsVictor TybulewiczFull details Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis Authors (8) Lindsey Mayes-Hopfinger Aura Enache Jian Xie Chou-Long HuangRobert KoechlVictor Tybulewicz Teresa Fernandes-Alnemri Emad S Alnemri Nature Communications Published 27 July 2021 Crick labsVictor TybulewiczFull details Maternal iron deficiency perturbs embryonic cardiovascular development in mice Authors (22) Jacinta I Kalisch-Smith Nikita Ved Dorota Szumska Jacob Munro Michael Troup Shelley E Harris[...] Timothy J Mohun Samira Lakhal-Littleton Sarah De Val Eleni Giannoulatou Duncan B Sparrow Nature Communications Published 8 June 2021 Crick labs/ facilitiesVictor TybulewiczTim MohunLight MicroscopyFull details Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models Authors (13) Justin L Tosh Elena R Rhymes Paige Mumford Heather T Whittaker Laura J Pulford Sue J Noy[...] Matthew C Walker Victor LJ Tybulewicz Rob C Wykes Elizabeth MC Fisher Frances K Wiseman Scientific Reports Published 11 March 2021 Crick labsVictor TybulewiczFull details Pagination Current page 1 Page 2 Page 3 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20)Eva Lana-ElolaRifdat Aoidi Miriam LlorianDorota GibbinsCallan BuechsenschuetzClaudio Bussi[...] Laurent MeijerBram SnijdersMaximiliano Gutierrez Elizabeth MC FisherVictor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilitiesVictor TybulewiczMaximiliano GutierrezProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
T cell migration requires ion and water influx to regulate actin polymerization Authors (13)Leon De BoerLesley Vanes Serena MelgratiJoshua Biggs O'MayDarryl HaywardPaul Driscoll[...] Renata Magueta Alexander MorrellJames MacraeRobert KoechlVictor Tybulewicz Nature Communications Published 6 December 2023 Crick labs/ facilitiesVictor TybulewiczMetabolomicsLight MicroscopyFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome Authors (13) ME Serrano E KimBernard Siow D Ma L Rojo C Simmons[...] N Singh A Strydom EMC FisherVictor Tybulewicz D Cash Neurobiology of Disease Published 1 November 2023 Crick labs/ facilitiesVictor TybulewiczIn Vivo ImagingBiological Research FacilityFull details
Affordable optical clearing and immunolabelling in mouse brain slices Authors (8) Phillip M Muza Marta Pérez Suzanna Noy Miyu Kurosawa Loukia KatsouriVictor Tybulewicz Elizabeth MC Fisher Steven J West BMC Research Notes Published 30 September 2023 Crick labsVictor TybulewiczFull details
Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes Authors (10)Yushi RedheadDorota GibbinsEva Lana-Elola Sheona Watson-Scales Lisa Dobson Matthias Krause Karen J Liu Elizabeth MC Fisher Jeremy BA GreenVictor Tybulewicz Development Published 15 April 2023 Crick labsVictor TybulewiczFull details
Genetic dissection of triplicated chromosome 21 orthologs yields varying skeletal traits in Down syndrome model mice Authors (11) Kourtney Sloan Jared Thomas Matthew Blackwell Deanna VoisardEva Lana-Elola Sheona Watson-Scales Daniel L Roper Joseph M Wallace Elizabeth MC FisherVictor Tybulewicz Randall J Roper Disease Models and Mechanisms Published 1 April 2023 Crick labsVictor TybulewiczFull details
Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture Authors (13) PM Muza D Bush M Pérez-González I Zouhair K Cleverley M Llorian-Sopena[...] M GoodVictor Tybulewicz MC Walker EMC Fisher P Chang iScience Published 17 February 2023 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsFull details
B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice Authors (11)Darryl HaywardLesley Vanes Stefanie Wissmann Sujana Sivapatham Harald HartwegerJoshua Biggs O'MayLeon De Boer Richard MitterRobert Koechl Jens V SteinVictor Tybulewicz Journal of Experimental Medicine Published 6 March 2023 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsMedia PreparationLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Antidepressants cheer up hepatic B1 B cells: Hope for the treatment of autoimmune liver diseases? Authors (2)Timm AmendtVictor Tybulewicz Frontiers in Immunology Published 17 January 2023 Crick labsVictor TybulewiczFull details
Genetic mapping of APP and amyloid-β biology modulation by trisomy 21 Authors (17) Paige Mumford Justin Tosh Silvia Anderle Eleni Gkanatsiou Wikberg Gloria Lau Sue Noy[...] Kaj Blennow Henrik ZetterbergVictor Tybulewicz Elizabeth MC Fisher Frances K Wiseman The Journal of Neuroscience Published 17 August 2022 Crick labsVictor TybulewiczFull details
Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome Authors (7) Claudia Cannavo Karen Cleverley Cheryl Maduro Paige Mumford Dale Moulding Elizabeth MC Fisher Frances K Wiseman PLOS ONE Published 11 May 2022 Crick labsVictor TybulewiczFull details
Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift Authors (21) Yang Zhang Laura Garcia-Ibanez Carolin Ulbricht Laurence SC Lok Jeremy A PikeJennifer Mueller-Winkler[...]Victor Tybulewicz Antal Rot Anja E Hauser Menna R Clatworthy Kai-Michael Toellner Nature Communications Published 5 May 2022 Crick labsVictor TybulewiczFull details
Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration Authors (11) Emilie J Cosway Andrea J White Sonia M ParnellEdina Schweighoffer Helen E Jolin Andrea Bacon Hans-Reimer RodewaldVictor Tybulewicz Andrew NJ McKenzie William E Jenkinson Graham Anderson Science Immunology Published 1 March 2022 Crick labsVictor TybulewiczFull details
Mouse models of aneuploidy to understand chromosome disorders Authors (3)Justin ToshVictor Tybulewicz Elizabeth MC Fisher Mammalian Genome Published 1 March 2022 Crick labsVictor TybulewiczFull details
A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome Authors (10) Nicolas ToussaintYushi Redhead Marta Vidal-García Lucas Lo Vercio Wei Liu Elizabeth MC Fisher Benedikt HallgrímssonVictor Tybulewicz Julia A Schnabel Jeremy BA Green Development Published 15 September 2021 Crick labsVictor TybulewiczFull details
Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes Authors (26)Eva Lana-Elola Heather Cater Sheona Watson-Scales Simon GreenawayJennifer Mueller-WinklerDorota Gibbins[...] Michelle Simon Ann-Marie Mallon Sara Wells Elizabeth MC FisherVictor Tybulewicz Disease Models and Mechanisms Published 1 October 2021 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
BAFF signaling in health and disease Authors (2)Edina SchweighofferVictor Tybulewicz Current Opinion in Immunology Published 1 August 2021 Crick labsVictor TybulewiczFull details
Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis Authors (8) Lindsey Mayes-Hopfinger Aura Enache Jian Xie Chou-Long HuangRobert KoechlVictor Tybulewicz Teresa Fernandes-Alnemri Emad S Alnemri Nature Communications Published 27 July 2021 Crick labsVictor TybulewiczFull details
Maternal iron deficiency perturbs embryonic cardiovascular development in mice Authors (22) Jacinta I Kalisch-Smith Nikita Ved Dorota Szumska Jacob Munro Michael Troup Shelley E Harris[...] Timothy J Mohun Samira Lakhal-Littleton Sarah De Val Eleni Giannoulatou Duncan B Sparrow Nature Communications Published 8 June 2021 Crick labs/ facilitiesVictor TybulewiczTim MohunLight MicroscopyFull details
Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models Authors (13) Justin L Tosh Elena R Rhymes Paige Mumford Heather T Whittaker Laura J Pulford Sue J Noy[...] Matthew C Walker Victor LJ Tybulewicz Rob C Wykes Elizabeth MC Fisher Frances K Wiseman Scientific Reports Published 11 March 2021 Crick labsVictor TybulewiczFull details