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Breadcrumb Victor Tybulewicz Tybulewicz lab Immune Cell Biology Laboratory & Down Syndrome Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Image taken by Rifdat Aoidi using microscopes in the Light Microscopy STP. Toggle to view hero caption PublicationsYear published2024 (1)2023 (8)2022 (4)2021 (7)2020 (9)2019 (4)2018 (6)2017 (5)2016 (9)2015 (4)2014 (5)2013 (5)2012 (7)2011 (6)2010 (11) Facet Year publishedResearch topicsCell Biology (58)Developmental Biology (58)Human Biology & Physiology (58)Immunology (58)Model Organisms (58)Signalling & Oncogenes (58)Computational & Systems Biology (8)Genetics & Genomics (8)Tumour Biology (7)Chemical Biology & High Throughput (6)Genome Integrity & Repair (6)Imaging (4)Infectious Disease (4)Biochemistry & Proteomics (3)Gene Expression (3)Neurosciences (3)Synthetic Biology (2)Metabolism (1)Stem Cells (1) Facet Research topicsPublication typeJournal article (91)Primary research (78)Review (12)Method (1) Facet Publication typeJournalJournal of Experimental Medicine (6)PLOS ONE (6)Blood (5)Nature Communications (5)eLife (4)Journal of Immunology (3)Alzheimer's and Dementia (2)Alzheimer's Research and Therapy (2)Cell Reports (2)Development (2)Disease Models & 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of the United States of America (1)Science (1)Science Immunology (1)Science Signaling (1)Science Translational Medicine (1)Scientific World Journal (1)The Journal of Neuroscience (1)Transplant Immunology (1) Facet Journal Publications Displaying 21 - 40 of 91Last updated : 24 April 2024 02:55 Optimal age and outcome measures for Alzheimer's disease prevention trials in people with Down syndrome Authors (14) R Hithersay RA Baksh CM Startin P Wijeratne S Hamburg B Carter[...] E Fisher D Nizetic J HardyVictor Tybulewicz A Karmiloff-Smith Alzheimer's and Dementia Published 1 April 2021 Crick labsVictor TybulewiczFull details Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival Authors (8)Jennifer Mueller-Winkler Richard MitterJulie RappeLesley VanesEdina SchweighofferHamid MohammadiAndreas WackVictor Tybulewicz Journal of Experimental Medicine Published 1 February 2021 Crick labs/ facilitiesAndreas WackVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Critical role of WNK1 in MYC-dependent early mouse thymocyte development Authors (10)Robert KoechlLesley VanesMiriam Llorian Sopena Probir Chakravarty Harald Hartweger Kathryn Fountain Andrea White Jennifer Cowan Graham AndersonVictor Tybulewicz eLife Published 14 October 2020 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryCell ServicesBiological Research FacilityAdvanced SequencingFull details Species-specific pace of development is associated with differences in protein stability Authors (11)Teresa Rayon AlonsoDespina Stamataki Ruben Perez-CarrascoLorena Garcia-Perez Christopher BarringtonManuela MelchiondaKatherine Exelby Jorge LazaroVictor Tybulewicz Elizabeth MC FisherJames Briscoe Science Published 18 September 2020 Crick labs/ facilitiesVictor TybulewiczJames BriscoeBioinformatics and BiostatisticsFull details Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellar cortex of the Tc1 mouse model of Down Syndrome - a comprehensive morphometric analysis with active staining contrast-enhanced MRI Authors (19) Da Ma Manuel J Cardoso Maria A Zuluaga Marc Modat Nick M Powell Frances K Wiseman[...] Mirza Faisal BegVictor Tybulewicz Elizabeth MC Fisher Mark F Lythgoe S Ebastien Ourselin NeuroImage Published 1 December 2020 Crick labs/ facilitiesVictor TybulewiczIn Vivo ImagingBiological Research FacilityFull details Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain Authors (43) Ivan Alić Pollyanna A Goh Aoife Murray Erik Portelius Eleni Gkanatsiou Gillian Gough[...] Kaj Blennow Andre Strydom John Hardy Henrik Zetterberg Dean Nižetić Molecular Psychiatry Published 1 October 2021 Crick labsVictor TybulewiczFull details Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with Down syndrome Authors (9) Jared R Thomas Jonathan LaCombe Rachel LongEva Lana-Elola Sheona Watson-Scales Joseph M Wallace Elizabeth MC FisherVictor Tybulewicz Randall J Roper Bone Published 1 July 2020 Crick labsVictor TybulewiczFull details Altered hippocampal-prefrontal neural dynamics in mouse models of Down syndrome Authors (12) Pishan Chang Daniel Bush Stephanie Schorge Mark Good Tara Canonica Nathanael Shing[...] Frances K Wiseman Neil BurgessVictor Tybulewicz Matthew C Walker Elizabeth MC Fisher Cell Reports Published 28 January 2020 Crick labs/ facilitiesVictor TybulewiczBiological Research FacilityFull details Health comorbidities and cognitive abilities across the lifespan in Down syndrome Authors (11) Carla M Startin Hana D'Souza George Ball Sarah Hamburg Rosalyn Hithersay Kate MO Hughes Esha Massand Annette Karmiloff-Smith Michael SC Thomas LonDownS Consortium Andre Strydom Journal of Neurodevelopmental Disorders Published 23 January 2020 Crick labsVictor TybulewiczFull details Gene expression dysregulation domains are not a specific feature of Down syndrome Authors (12) Helena Ahlfors Nnneka Anyanwu Edvinas Pakanavicius Natalia DinischiotuEva Lana-Elola Sheona Watson-Scales[...] Frances WisemanJames Briscoe Karen Page Elizabeth MC FisherVictor Tybulewicz Nature Communications Published 6 June 2019 Crick labs/ facilitiesVictor TybulewiczJames BriscoeGenetic Modification ServiceBiological Research FacilityAdvanced SequencingFull details Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus Authors (15) Simone Granno Jonathon Nixon-Abell Daniel C Berwick Justin Tosh George Heaton Sultan Almudimeegh[...]Victor Tybulewicz Karen Cleverley Frances K Wiseman Elizabeth MC Fisher Kirsten Harvey Scientific Reports Published 13 May 2019 Crick labs/ facilitiesVictor TybulewiczBiological Research FacilityFull details Validating the cognitive scale for Down syndrome (CS-DS) to detect longitudinal cognitive decline in adults with Down syndrome Authors (13) CM Startin B Lowe S Hamburg R Hithersay A Strydom LonDownS Consortium[...] J Hardy Lee Kong Chian Reta Lila WestonVictor Tybulewicz A Karmiloff-Smith Frontiers in Psychiatry Published 16 April 2019 Crick labsVictor TybulewiczFull details Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease Authors (14) Carla M Startin Nicholas J Ashton Sarah Hamburg Rosalyn Hithersay Frances K Wiseman Kin Y Mok[...] Lucilla Parnetti Henrik Zetterberg Abdul Hye LonDownS Consortium André Strydom Alzheimer's Research and Therapy Published 21 March 2019 Crick labsVictor TybulewiczFull details Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome Authors (23) CM Startin S Hamburg R Hithersay T Al-Janabi KY Mok J Hardy[...] B Knight AM Prins R Sheehan D Zhang LonDownS Consortium Alzheimer's and Dementia Published 1 February 2019 Crick labsVictor TybulewiczFull details Association of dementia with mortality among adults with Down syndrome older than 35 years Authors (9) Rosalyn Hithersay Carla M Startin Sarah Hamburg Kin Y Mok John Hardy Elizabeth MC FisherVictor Tybulewicz Dean Nizetic André Strydom JAMA Neurology Published 1 February 2019 Crick labsVictor TybulewiczFull details Plasmodium-specific atypical memory B cells are short-lived activated B cells Authors (10)Damian Mazliah Peter J GardnerEdina Schweighoffer Sarah McLaughlinCaroline HoskingIrene Tumwine Randall S Davis Alexandre J PotocnikVictor Tybulewicz Jean Langhorne eLife Published 2 November 2018 Crick labs/ facilitiesVictor TybulewiczJean LanghorneFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP Authors (29) Frances K Wiseman Laura J Pulford Chris Barkus Fan Liao Erik Portelius Robin Webb[...] Henrik Zetterberg David Bannerman David M HoltzmanVictor Tybulewicz Elizabeth MC Fisher Brain Published 26 June 2018 Crick labsVictor TybulewiczBart de Strooper | Lorena ArancibiaFull details Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration Authors (19) Sheona Watson-Scales Bernadett KalmarEva Lana-ElolaDorota Gibbins Federica La Russa Frances Wiseman[...] Y Eugene YuDamaris Bennett Linda Greensmith Elizabeth MC FisherVictor Tybulewicz PLOS Genetics Published 10 May 2018 Crick labs/ facilitiesVictor TybulewiczExperimental HistopathologyLight MicroscopyExperimental HistopathologyBiological Research FacilityFull details Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome Authors (14) A Strydom A Heslegrave CM Startin KY Mok J Hardy J Groet[...]Victor Tybulewicz A Karmiloff-Smith S Hamburg R Hithersay The LonDownS Consotium Alzheimer's Research and Therapy Published 10 April 2018 Crick labsVictor TybulewiczFull details In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome Authors (8) Gaëlle Naert Valentine Ferré Emeline Keller Amy SlenderDorota Gibbins Elizabeth MC FisherVictor Tybulewicz Tangui Maurice Journal of Psychopharmacology Published 1 February 2018 Crick labsVictor TybulewiczFull details Pagination First page First Previous page Previous Page 1 Current page 2 Page 3 Page 4 Page 5 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Optimal age and outcome measures for Alzheimer's disease prevention trials in people with Down syndrome Authors (14) R Hithersay RA Baksh CM Startin P Wijeratne S Hamburg B Carter[...] E Fisher D Nizetic J HardyVictor Tybulewicz A Karmiloff-Smith Alzheimer's and Dementia Published 1 April 2021 Crick labsVictor TybulewiczFull details
Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival Authors (8)Jennifer Mueller-Winkler Richard MitterJulie RappeLesley VanesEdina SchweighofferHamid MohammadiAndreas WackVictor Tybulewicz Journal of Experimental Medicine Published 1 February 2021 Crick labs/ facilitiesAndreas WackVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
Critical role of WNK1 in MYC-dependent early mouse thymocyte development Authors (10)Robert KoechlLesley VanesMiriam Llorian Sopena Probir Chakravarty Harald Hartweger Kathryn Fountain Andrea White Jennifer Cowan Graham AndersonVictor Tybulewicz eLife Published 14 October 2020 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryCell ServicesBiological Research FacilityAdvanced SequencingFull details
Species-specific pace of development is associated with differences in protein stability Authors (11)Teresa Rayon AlonsoDespina Stamataki Ruben Perez-CarrascoLorena Garcia-Perez Christopher BarringtonManuela MelchiondaKatherine Exelby Jorge LazaroVictor Tybulewicz Elizabeth MC FisherJames Briscoe Science Published 18 September 2020 Crick labs/ facilitiesVictor TybulewiczJames BriscoeBioinformatics and BiostatisticsFull details
Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellar cortex of the Tc1 mouse model of Down Syndrome - a comprehensive morphometric analysis with active staining contrast-enhanced MRI Authors (19) Da Ma Manuel J Cardoso Maria A Zuluaga Marc Modat Nick M Powell Frances K Wiseman[...] Mirza Faisal BegVictor Tybulewicz Elizabeth MC Fisher Mark F Lythgoe S Ebastien Ourselin NeuroImage Published 1 December 2020 Crick labs/ facilitiesVictor TybulewiczIn Vivo ImagingBiological Research FacilityFull details
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain Authors (43) Ivan Alić Pollyanna A Goh Aoife Murray Erik Portelius Eleni Gkanatsiou Gillian Gough[...] Kaj Blennow Andre Strydom John Hardy Henrik Zetterberg Dean Nižetić Molecular Psychiatry Published 1 October 2021 Crick labsVictor TybulewiczFull details
Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with Down syndrome Authors (9) Jared R Thomas Jonathan LaCombe Rachel LongEva Lana-Elola Sheona Watson-Scales Joseph M Wallace Elizabeth MC FisherVictor Tybulewicz Randall J Roper Bone Published 1 July 2020 Crick labsVictor TybulewiczFull details
Altered hippocampal-prefrontal neural dynamics in mouse models of Down syndrome Authors (12) Pishan Chang Daniel Bush Stephanie Schorge Mark Good Tara Canonica Nathanael Shing[...] Frances K Wiseman Neil BurgessVictor Tybulewicz Matthew C Walker Elizabeth MC Fisher Cell Reports Published 28 January 2020 Crick labs/ facilitiesVictor TybulewiczBiological Research FacilityFull details
Health comorbidities and cognitive abilities across the lifespan in Down syndrome Authors (11) Carla M Startin Hana D'Souza George Ball Sarah Hamburg Rosalyn Hithersay Kate MO Hughes Esha Massand Annette Karmiloff-Smith Michael SC Thomas LonDownS Consortium Andre Strydom Journal of Neurodevelopmental Disorders Published 23 January 2020 Crick labsVictor TybulewiczFull details
Gene expression dysregulation domains are not a specific feature of Down syndrome Authors (12) Helena Ahlfors Nnneka Anyanwu Edvinas Pakanavicius Natalia DinischiotuEva Lana-Elola Sheona Watson-Scales[...] Frances WisemanJames Briscoe Karen Page Elizabeth MC FisherVictor Tybulewicz Nature Communications Published 6 June 2019 Crick labs/ facilitiesVictor TybulewiczJames BriscoeGenetic Modification ServiceBiological Research FacilityAdvanced SequencingFull details
Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus Authors (15) Simone Granno Jonathon Nixon-Abell Daniel C Berwick Justin Tosh George Heaton Sultan Almudimeegh[...]Victor Tybulewicz Karen Cleverley Frances K Wiseman Elizabeth MC Fisher Kirsten Harvey Scientific Reports Published 13 May 2019 Crick labs/ facilitiesVictor TybulewiczBiological Research FacilityFull details
Validating the cognitive scale for Down syndrome (CS-DS) to detect longitudinal cognitive decline in adults with Down syndrome Authors (13) CM Startin B Lowe S Hamburg R Hithersay A Strydom LonDownS Consortium[...] J Hardy Lee Kong Chian Reta Lila WestonVictor Tybulewicz A Karmiloff-Smith Frontiers in Psychiatry Published 16 April 2019 Crick labsVictor TybulewiczFull details
Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease Authors (14) Carla M Startin Nicholas J Ashton Sarah Hamburg Rosalyn Hithersay Frances K Wiseman Kin Y Mok[...] Lucilla Parnetti Henrik Zetterberg Abdul Hye LonDownS Consortium André Strydom Alzheimer's Research and Therapy Published 21 March 2019 Crick labsVictor TybulewiczFull details
Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome Authors (23) CM Startin S Hamburg R Hithersay T Al-Janabi KY Mok J Hardy[...] B Knight AM Prins R Sheehan D Zhang LonDownS Consortium Alzheimer's and Dementia Published 1 February 2019 Crick labsVictor TybulewiczFull details
Association of dementia with mortality among adults with Down syndrome older than 35 years Authors (9) Rosalyn Hithersay Carla M Startin Sarah Hamburg Kin Y Mok John Hardy Elizabeth MC FisherVictor Tybulewicz Dean Nizetic André Strydom JAMA Neurology Published 1 February 2019 Crick labsVictor TybulewiczFull details
Plasmodium-specific atypical memory B cells are short-lived activated B cells Authors (10)Damian Mazliah Peter J GardnerEdina Schweighoffer Sarah McLaughlinCaroline HoskingIrene Tumwine Randall S Davis Alexandre J PotocnikVictor Tybulewicz Jean Langhorne eLife Published 2 November 2018 Crick labs/ facilitiesVictor TybulewiczJean LanghorneFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP Authors (29) Frances K Wiseman Laura J Pulford Chris Barkus Fan Liao Erik Portelius Robin Webb[...] Henrik Zetterberg David Bannerman David M HoltzmanVictor Tybulewicz Elizabeth MC Fisher Brain Published 26 June 2018 Crick labsVictor TybulewiczBart de Strooper | Lorena ArancibiaFull details
Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration Authors (19) Sheona Watson-Scales Bernadett KalmarEva Lana-ElolaDorota Gibbins Federica La Russa Frances Wiseman[...] Y Eugene YuDamaris Bennett Linda Greensmith Elizabeth MC FisherVictor Tybulewicz PLOS Genetics Published 10 May 2018 Crick labs/ facilitiesVictor TybulewiczExperimental HistopathologyLight MicroscopyExperimental HistopathologyBiological Research FacilityFull details
Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome Authors (14) A Strydom A Heslegrave CM Startin KY Mok J Hardy J Groet[...]Victor Tybulewicz A Karmiloff-Smith S Hamburg R Hithersay The LonDownS Consotium Alzheimer's Research and Therapy Published 10 April 2018 Crick labsVictor TybulewiczFull details
In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome Authors (8) Gaëlle Naert Valentine Ferré Emeline Keller Amy SlenderDorota Gibbins Elizabeth MC FisherVictor Tybulewicz Tangui Maurice Journal of Psychopharmacology Published 1 February 2018 Crick labsVictor TybulewiczFull details