Uncovering new Wnt regulatory mechanism

SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization
  • 27 February 2019
SH3BP4 summary

Research highlight

PhD student Pedro Antas uncovers new Wnt regulator SH3BP4. We show that loss of Sh3bp4 increases intestinal stem cell numbers and accelerates tumour development. Our data uncover the tumor-suppressive role of SH3BP4 that functions as a negative feedback regulator of Wnt signaling through modulating β-catenin’s subcellular localization.

The data is published in this issue's Cell Reports.

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