Joerg Albert

GROUP LEADER - SATELLITE

My fascination with the field of sensory biology and neuroscience dates back to the summer of 1981, I guess.

Rather than reflecting the (prematurely) academic mind of a 10-year old school boy, it resulted from a summer-long observation of a population of hunting spiders in my parents’ orchard (including some first detailed anatomical inspections with a freshly acquired little toy microscope). Spiders, these predominantly nocturnal beings that so radically (and some even blindly) relied on their mechanosensory skills of detecting the minutest of all vibrations to tell predator from prey, impressed me deeply. So, at least in retrospect, it seems to have been just a matter of course that I eventually turned my professional interests to the biological sciences and my biological interests to the field of mechanosensation, i.e. the sensations of touch, balance, vibration and hearing. 

For my PhD, I joined the neurobiology lab of Friedrich G. Barth at the University of Vienna where I became familiar with the imposing richness of spider mechanosensory organs. In the biophysics lab of Martin Göpfert at the University of Cologne then, I was lucky enough to spend a fantastic 4-year ‘postdoc’ time during which I not only converted from a spider- to an insect-man but, even more, to a confessing Drosophilist (!). Accordingly, I shifted the centre of my research interest from the touch sense of spiders to the antennal ears of the fruit fly Drosophila melanogaster. We are studying these in a dual effort: To understand insect hearing and its sensory ecological importance and to translate this understanding to human hearing (and deafness). 

Insects and mammals (like mice and men) share a common evolutionary history of roughly 3 billion years which is still reflected by a considerable overlap of the molecular and mechanistic machineries that orchestrate the development of their ears. The fly gene atonal, for example, has a very similar mouse counterpart, called MATH1. Most intriguingly, atonal can fully rescue the phenotype of MATH1-deficient mice, convincingly demonstrating the equivalence and conservation of the proteins' developmental functions. In addition to this molecular-level kinship, a second force is producing congruencies between auditory systems across the taxa and this is to do with physical constraints: The ears of flies and humans are faced with very similar biophysical problems and they also came to very similar solutions. In other cases, insects have used the same molecular building blocks as humans to enable novel sensory performances. In both cases, studying the one, helps understanding the other.  

And, finally, much of what we know about the workings of our own ears we have learned from experiments in animals as strange as bullfrogs, turtles or chicken, anyway. So why not let little Drosophila (or slightly bigger Anopheles) contribute to our understanding of hearing and deafness? I am sure this can fly.
 

Qualifications and history

1998
University of Erlangen-Nuremberg
Diploma in Biology
2002
University of Vienna
PhD in Zoology
2002
University of Vienna
Postdoctoral Research
2003
University of Tübingen
Postdoctoral Research Associate (Secondment)
2003
University of Cologne
Postdoctoral Research Associate
2008
University College London
Deafness Research UK Research Fellow
2011
University College London
Senior Lecturer in Neuroscience
2014
University College London
Reader in Sensory Neuroscience
2016
University College London
Professor of Sensory Biology and Biophysics (Ear Institute)
2019
The Francis Crick Institute
Satellite lab leader

Year published

Publication type

Crick Pre-Crick

Displaying 1 - 1 of 1
Last updated : 26 September 2022 03:36