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Breadcrumb Advanced Sequencing Advanced Sequencing : Publications Lab contentLab contentIn this section Overview Applications Equipment Publications Members A HiSeq flowcell. Credit: Fiona Byrne. Toggle to view hero caption Publications Displaying 1 - 10 of 346Last updated : 29 March 2024 03:54 FOXL2 interaction with different binding partners regulates the dynamics of ovarian development Authors (7)Roberta MigaleMichelle NeumannRichard MitterMahmoud-Reza RafieeSophie WoodJessica OlsenRobin Lovell-Badge Science advances Published 22 March 2024 Crick labs/ facilitiesJernej UleRobin Lovell-BadgeGenetic Modification ServiceBioinformatics and BiostatisticsProteomicsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia Authors (11)Fiona Grimm Agustín AsuajeAakriti JainMariana Silva Dos Santos Jens KleinjungPatricia Figueiredo Nunes Stefanie GehrigLouise Fets Salihanur DariciJames MacraeDimitrios Anastasiou The EMBO Journal Published 14 March 2024 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsBioinformatics and BiostatisticsLight MicroscopyHigh Throughput ScreeningAdvanced SequencingFull details Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 11 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner Authors (11) Silvia Peripolli Leticia Meneguello Chiara Perrod Tanya Singh Harshil Patel Sazia T Rahman Koshiro Kiso Peter Thorpe Vincenzo Calvanese Cosetta Bertoli Robertus AM de Bruin Nature Communications Published 21 February 2024 Crick labs/ facilitiesBioinformatics and BiostatisticsAdvanced SequencingFull details Distinct ontogenetic lineages dictate cDC2 heterogeneity Authors (15)Carlos Munoz MinuttiCecile PiotMariana Pereira Da Costa Probir ChakravartyNeil RogersHector Huerga Encabo[...] Jean LanghorneDominique Bonnet Marc Dalod Elena TomaselloCaetano Reis e Sousa Nature Immunology Published 1 March 2024 Crick labs/ facilitiesCaetano Reis e SousaJean LanghorneGeorge KassiotisDominique BonnetBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected Authors (14) Kelvin M Kimenyi Mercy Y Akinyi Kioko Mwikali Tegan Gilmore Shaban Mwangi Elisha Omer[...] George Obiero Philip Bejon Jean Langhorne Abdirahman Abdi Lynette Isabella Ochola-Oyier BMC Infectious Diseases Published 29 January 2024 Crick labs/ facilitiesJean LanghorneBioinformatics and BiostatisticsAdvanced SequencingFull details Detection of chromosomal aneuploidy in ancient genomes Authors (31)Kyriaki AnastasiadouMarina Soares Da SilvaThomas BoothLeo Speidel Tony Audsley Christopher Barrington[...] Malin Holst Louise Loe Ian Armit Rick SchultingPontus Skoglund Communications Biology Published 11 January 2024 Crick labs/ facilitiesPontus SkoglundBioinformatics and BiostatisticsAdvanced SequencingFull details The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma Authors (20) Xiaoxi Pan Khalid AbdulJabbar Jose Coelho-Lima Anca-Ioana Grapa Hanyun Zhang Alvin Ho Kwan Cheung[...] TRACERx ConsortiumCharles Swanton Yinyin Yuan John Le Quesne David A Moore Nature Cancer Published 1 February 2024 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonErik SahaiGeorge KassiotisFlow CytometryExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
FOXL2 interaction with different binding partners regulates the dynamics of ovarian development Authors (7)Roberta MigaleMichelle NeumannRichard MitterMahmoud-Reza RafieeSophie WoodJessica OlsenRobin Lovell-Badge Science advances Published 22 March 2024 Crick labs/ facilitiesJernej UleRobin Lovell-BadgeGenetic Modification ServiceBioinformatics and BiostatisticsProteomicsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia Authors (11)Fiona Grimm Agustín AsuajeAakriti JainMariana Silva Dos Santos Jens KleinjungPatricia Figueiredo Nunes Stefanie GehrigLouise Fets Salihanur DariciJames MacraeDimitrios Anastasiou The EMBO Journal Published 14 March 2024 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsBioinformatics and BiostatisticsLight MicroscopyHigh Throughput ScreeningAdvanced SequencingFull details
Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 11 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner Authors (11) Silvia Peripolli Leticia Meneguello Chiara Perrod Tanya Singh Harshil Patel Sazia T Rahman Koshiro Kiso Peter Thorpe Vincenzo Calvanese Cosetta Bertoli Robertus AM de Bruin Nature Communications Published 21 February 2024 Crick labs/ facilitiesBioinformatics and BiostatisticsAdvanced SequencingFull details
Distinct ontogenetic lineages dictate cDC2 heterogeneity Authors (15)Carlos Munoz MinuttiCecile PiotMariana Pereira Da Costa Probir ChakravartyNeil RogersHector Huerga Encabo[...] Jean LanghorneDominique Bonnet Marc Dalod Elena TomaselloCaetano Reis e Sousa Nature Immunology Published 1 March 2024 Crick labs/ facilitiesCaetano Reis e SousaJean LanghorneGeorge KassiotisDominique BonnetBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details
Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected Authors (14) Kelvin M Kimenyi Mercy Y Akinyi Kioko Mwikali Tegan Gilmore Shaban Mwangi Elisha Omer[...] George Obiero Philip Bejon Jean Langhorne Abdirahman Abdi Lynette Isabella Ochola-Oyier BMC Infectious Diseases Published 29 January 2024 Crick labs/ facilitiesJean LanghorneBioinformatics and BiostatisticsAdvanced SequencingFull details
Detection of chromosomal aneuploidy in ancient genomes Authors (31)Kyriaki AnastasiadouMarina Soares Da SilvaThomas BoothLeo Speidel Tony Audsley Christopher Barrington[...] Malin Holst Louise Loe Ian Armit Rick SchultingPontus Skoglund Communications Biology Published 11 January 2024 Crick labs/ facilitiesPontus SkoglundBioinformatics and BiostatisticsAdvanced SequencingFull details
The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma Authors (20) Xiaoxi Pan Khalid AbdulJabbar Jose Coelho-Lima Anca-Ioana Grapa Hanyun Zhang Alvin Ho Kwan Cheung[...] TRACERx ConsortiumCharles Swanton Yinyin Yuan John Le Quesne David A Moore Nature Cancer Published 1 February 2024 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonErik SahaiGeorge KassiotisFlow CytometryExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details