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Breadcrumb Advanced Sequencing Advanced Sequencing : Publications Lab contentLab contentIn this section Overview Applications Equipment Publications Members A HiSeq flowcell. Credit: Fiona Byrne. Toggle to view hero caption Publications Displaying 11 - 20 of 350Last updated : 24 April 2024 03:30 Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected Authors (14) Kelvin M Kimenyi Mercy Y Akinyi Kioko MwikaliTegan Gilmore Shaban Mwangi Elisha Omer[...] George Obiero Philip Bejon Jean Langhorne Abdirahman Abdi Lynette Isabella Ochola-Oyier BMC Infectious Diseases Published 29 January 2024 Crick labs/ facilitiesJean LanghorneBioinformatics and BiostatisticsAdvanced SequencingFull details Detection of chromosomal aneuploidy in ancient genomes Authors (31)Kyriaki AnastasiadouMarina Soares Da SilvaThomas BoothLeo Speidel Tony Audsley Christopher Barrington[...] Malin Holst Louise Loe Ian Armit Rick SchultingPontus Skoglund Communications Biology Published 11 January 2024 Crick labs/ facilitiesPontus SkoglundBioinformatics and BiostatisticsAdvanced SequencingFull details The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma Authors (20) Xiaoxi Pan Khalid AbdulJabbar Jose Coelho-Lima Anca-Ioana Grapa Hanyun Zhang Alvin Ho Kwan Cheung[...] TRACERx ConsortiumCharles Swanton Yinyin Yuan John Le Quesne David A Moore Nature Cancer Published 1 February 2024 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonErik SahaiGeorge KassiotisFlow CytometryExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes Authors (18) Benjamin B Johnson Marie-Victoire CossonLorenza Iolanda Tsansizi Terri L HolmesTegan Gilmore Katherine Hampton[...] John Whitelock Linda Troeberg Stuart A Rushworth Andreia S Bernardo James GW Smith Cell Reports Published 23 January 2024 Crick labs/ facilitiesJim SmithHigh Throughput ScreeningBioinformatics and BiostatisticsStructural BiologyMaking LabAdvanced SequencingFull details A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation Authors (16) Cory A Ocasio Marc P Baggelaar James Sipthorp Ana Losada de la Lastra Manuel Tavares Jana Volarić[...]Goran TomicCharlotte CarrJulian Downward Ulrike S Eggert Edward W Tate Nature Biotechnology Published 8 January 2024 Crick labs/ facilitiesEd TateJulian DownwardMetabolomicsFlow CytometryChemical BiologyProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy Authors (16) Daniel Davies Shraddha Kamdar Richard Woolf Iva Zlatareva Maria Luisa Iannitto Cienne Morton[...] Cheryl GillettOlga O'Neill Oliver NussbaumerAdrian Hayday Yin Wu Nature Cancer Published 1 March 2024 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details An individual with Sarmatian-related ancestry in Roman Britain Authors (14)Marina Soares Da SilvaThomas Booth Joanna MooreKyriaki Anastasiadou Don WalkerAlexandre Gilardet[...] Michael Henderson Alex Smith David Bowsher Janet MontgomeryPontus Skoglund Current Biology Published 8 January 2024 Crick labs/ facilitiesPontus SkoglundBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details Innate TCRβ-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials Authors (16) Pierre Vantourout Josephine Eum María Conde Poole Thomas S Hayday Adam G Laing Khiyam Hussain[...] Roya Servattalab Jonathan Hsu Andrew Bayliffe Madan KatragaddaAdrian Hayday Science advances Published 8 December 2023 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details SARS-CoV-2 mucosal neutralising immunity after vaccination Authors (38)Edward Carr Guilia Dowgier David Greenwood Lou S Herman Agnieszka Hobbs Martina Ragno[...]Charles SwantonSonia GandhiDavid LV Bauer Emma WallMary Wu Lancet Infectious Diseases Published 1 January 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingFull details Pagination First page First Previous page Previous Page 1 Current page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page 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Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details
Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected Authors (14) Kelvin M Kimenyi Mercy Y Akinyi Kioko MwikaliTegan Gilmore Shaban Mwangi Elisha Omer[...] George Obiero Philip Bejon Jean Langhorne Abdirahman Abdi Lynette Isabella Ochola-Oyier BMC Infectious Diseases Published 29 January 2024 Crick labs/ facilitiesJean LanghorneBioinformatics and BiostatisticsAdvanced SequencingFull details
Detection of chromosomal aneuploidy in ancient genomes Authors (31)Kyriaki AnastasiadouMarina Soares Da SilvaThomas BoothLeo Speidel Tony Audsley Christopher Barrington[...] Malin Holst Louise Loe Ian Armit Rick SchultingPontus Skoglund Communications Biology Published 11 January 2024 Crick labs/ facilitiesPontus SkoglundBioinformatics and BiostatisticsAdvanced SequencingFull details
The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma Authors (20) Xiaoxi Pan Khalid AbdulJabbar Jose Coelho-Lima Anca-Ioana Grapa Hanyun Zhang Alvin Ho Kwan Cheung[...] TRACERx ConsortiumCharles Swanton Yinyin Yuan John Le Quesne David A Moore Nature Cancer Published 1 February 2024 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonErik SahaiGeorge KassiotisFlow CytometryExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes Authors (18) Benjamin B Johnson Marie-Victoire CossonLorenza Iolanda Tsansizi Terri L HolmesTegan Gilmore Katherine Hampton[...] John Whitelock Linda Troeberg Stuart A Rushworth Andreia S Bernardo James GW Smith Cell Reports Published 23 January 2024 Crick labs/ facilitiesJim SmithHigh Throughput ScreeningBioinformatics and BiostatisticsStructural BiologyMaking LabAdvanced SequencingFull details
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation Authors (16) Cory A Ocasio Marc P Baggelaar James Sipthorp Ana Losada de la Lastra Manuel Tavares Jana Volarić[...]Goran TomicCharlotte CarrJulian Downward Ulrike S Eggert Edward W Tate Nature Biotechnology Published 8 January 2024 Crick labs/ facilitiesEd TateJulian DownwardMetabolomicsFlow CytometryChemical BiologyProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details
PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy Authors (16) Daniel Davies Shraddha Kamdar Richard Woolf Iva Zlatareva Maria Luisa Iannitto Cienne Morton[...] Cheryl GillettOlga O'Neill Oliver NussbaumerAdrian Hayday Yin Wu Nature Cancer Published 1 March 2024 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details
An individual with Sarmatian-related ancestry in Roman Britain Authors (14)Marina Soares Da SilvaThomas Booth Joanna MooreKyriaki Anastasiadou Don WalkerAlexandre Gilardet[...] Michael Henderson Alex Smith David Bowsher Janet MontgomeryPontus Skoglund Current Biology Published 8 January 2024 Crick labs/ facilitiesPontus SkoglundBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details
Innate TCRβ-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials Authors (16) Pierre Vantourout Josephine Eum María Conde Poole Thomas S Hayday Adam G Laing Khiyam Hussain[...] Roya Servattalab Jonathan Hsu Andrew Bayliffe Madan KatragaddaAdrian Hayday Science advances Published 8 December 2023 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details
SARS-CoV-2 mucosal neutralising immunity after vaccination Authors (38)Edward Carr Guilia Dowgier David Greenwood Lou S Herman Agnieszka Hobbs Martina Ragno[...]Charles SwantonSonia GandhiDavid LV Bauer Emma WallMary Wu Lancet Infectious Diseases Published 1 January 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingFull details
