Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Advanced Sequencing Advanced Sequencing : Publications Lab contentLab contentIn this section Overview Applications Equipment Publications Members A HiSeq flowcell. Credit: Fiona Byrne. Toggle to view hero caption Publications Displaying 21 - 30 of 349Last updated : 16 April 2024 03:48 The -KTS splice variant of WT1 is essential for ovarian determination in mice Authors (20) Elodie P Gregoire Marie-Cécile De CianRoberta Migale Aitana Perea-Gomez Sébastien Schaub Natividad Bellido-Carreras[...]Robin Lovell-Badge Serge Nef Frédéric Chalmel Andreas Schedl Marie-Christine Chaboissier Science Published 3 November 2023 Crick labs/ facilitiesRobin Lovell-BadgeBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription Authors (10)Simon Butterworth Kristina Kordova Sambamurthy Chandrasekaran Kaitlin K ThomasFrancesca TorelliEloise LockyerAmelia EdwardsRobert Goldstone Anita A KoshyMoritz Treeck Cell Host and Microbe Published 11 October 2023 Crick labs/ facilitiesMoritz TreeckAdvanced SequencingHigh Throughput ScreeningFlow CytometryCell ServicesFull details PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection Authors (19)Daniel Fisch Moritz M Pfleiderer Eleni Anastasakou Gillian M Mackie Fabian Wendt Xiangyang Liu[...] Avinash R Shenoy Bernd Wollscheid Kendle M Maslowski Wojtek P Galej Eva-Maria Frickel Science Published 6 October 2023 Crick labs/ facilitiesEva FrickelProteomicsHigh Throughput ScreeningAdvanced SequencingFull details SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context Authors (4)Karine Rizzoti Probir ChakravartyDaniel SheridanRobin Lovell-Badge Science advances Published 4 October 2023 Crick labs/ facilitiesRobin Lovell-BadgeBioinformatics and BiostatisticsLight MicroscopyExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Correction to Redfern et al. (2017) ‘Written in Bone’: New discoveries about the lives of Roman Londoners, Britannia 48, 253–77 Authors (8) Rebecca RedfernKyriaki AnastasiadouMarina Soares Da SilvaAlexandre GilardetMonica KellyMia Adrianna WilliamsThomas BoothPontus Skoglund Britannia Published 1 November 2023 Crick labs/ facilitiesPontus SkoglundAdvanced SequencingFull details The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level Authors (6)Gantas Perez MockusLuca CocconiCyrille AlexandreBirgit AerneGuillaume SalbreuxJean-Paul Vincent Developmental Cell Published 23 October 2023 Crick labs/ facilitiesJean-Paul VincentNic TaponGuillaume SalbreuxLight MicroscopyAdvanced SequencingFull details A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia Authors (15) Anna LaddachSong Hui ChngReena LasradoFranze ProgatzkyMichael Shapiro Alek Erickson[...] Jens KleinjungStefan BoeingSila Ultanir Igor AdameykoVassilis Pachnis Nature Communications Published 22 September 2023 Crick labs/ facilitiesSila UltanirVassilis PachnisBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease Authors (14) Robin J Dart Iva Zlatareva Pierre Vantourout Efstathios Theodoridis Ariella Amar Shichina Kannambath[...] Christopher A Lamb Miles Parkes Peter M Irving Natalie J PrescottAdrian Hayday Science Published 15 September 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details DNA-directed termination of RNA polymerase II transcription Authors (8) Zhong Han George A Moore Richard Mitter David Lopez MartinezLi Wan A Barbara Dirac Svejstrup David S RuedaJesper Svejstrup Molecular Cell Published 21 September 2023 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details Pagination First page First Previous page Previous Page 1 Page 2 Current page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The -KTS splice variant of WT1 is essential for ovarian determination in mice Authors (20) Elodie P Gregoire Marie-Cécile De CianRoberta Migale Aitana Perea-Gomez Sébastien Schaub Natividad Bellido-Carreras[...]Robin Lovell-Badge Serge Nef Frédéric Chalmel Andreas Schedl Marie-Christine Chaboissier Science Published 3 November 2023 Crick labs/ facilitiesRobin Lovell-BadgeBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription Authors (10)Simon Butterworth Kristina Kordova Sambamurthy Chandrasekaran Kaitlin K ThomasFrancesca TorelliEloise LockyerAmelia EdwardsRobert Goldstone Anita A KoshyMoritz Treeck Cell Host and Microbe Published 11 October 2023 Crick labs/ facilitiesMoritz TreeckAdvanced SequencingHigh Throughput ScreeningFlow CytometryCell ServicesFull details
PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection Authors (19)Daniel Fisch Moritz M Pfleiderer Eleni Anastasakou Gillian M Mackie Fabian Wendt Xiangyang Liu[...] Avinash R Shenoy Bernd Wollscheid Kendle M Maslowski Wojtek P Galej Eva-Maria Frickel Science Published 6 October 2023 Crick labs/ facilitiesEva FrickelProteomicsHigh Throughput ScreeningAdvanced SequencingFull details
SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context Authors (4)Karine Rizzoti Probir ChakravartyDaniel SheridanRobin Lovell-Badge Science advances Published 4 October 2023 Crick labs/ facilitiesRobin Lovell-BadgeBioinformatics and BiostatisticsLight MicroscopyExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Correction to Redfern et al. (2017) ‘Written in Bone’: New discoveries about the lives of Roman Londoners, Britannia 48, 253–77 Authors (8) Rebecca RedfernKyriaki AnastasiadouMarina Soares Da SilvaAlexandre GilardetMonica KellyMia Adrianna WilliamsThomas BoothPontus Skoglund Britannia Published 1 November 2023 Crick labs/ facilitiesPontus SkoglundAdvanced SequencingFull details
The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level Authors (6)Gantas Perez MockusLuca CocconiCyrille AlexandreBirgit AerneGuillaume SalbreuxJean-Paul Vincent Developmental Cell Published 23 October 2023 Crick labs/ facilitiesJean-Paul VincentNic TaponGuillaume SalbreuxLight MicroscopyAdvanced SequencingFull details
A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia Authors (15) Anna LaddachSong Hui ChngReena LasradoFranze ProgatzkyMichael Shapiro Alek Erickson[...] Jens KleinjungStefan BoeingSila Ultanir Igor AdameykoVassilis Pachnis Nature Communications Published 22 September 2023 Crick labs/ facilitiesSila UltanirVassilis PachnisBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease Authors (14) Robin J Dart Iva Zlatareva Pierre Vantourout Efstathios Theodoridis Ariella Amar Shichina Kannambath[...] Christopher A Lamb Miles Parkes Peter M Irving Natalie J PrescottAdrian Hayday Science Published 15 September 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details
DNA-directed termination of RNA polymerase II transcription Authors (8) Zhong Han George A Moore Richard Mitter David Lopez MartinezLi Wan A Barbara Dirac Svejstrup David S RuedaJesper Svejstrup Molecular Cell Published 21 September 2023 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details
