Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Advanced Sequencing Advanced Sequencing : Publications Lab contentLab contentIn this section Overview Applications Equipment Publications Members A HiSeq flowcell. Credit: Fiona Byrne. Toggle to view hero caption Publications Displaying 31 - 40 of 350Last updated : 24 April 2024 03:23 Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details Endothelial AHR activity prevents lung barrier disruption in viral infection Authors (13)Jack MajorStefania CrottaKatja Finsterbusch Probir ChakravartyKathleen ShahBruno Frederico[...] Lucy Meader Alejandro Suarez-BonnetSimon PriestnallBrigitta StockingerAndreas Wack Nature Published 28 September 2023 Crick labs/ facilitiesAndreas WackGitta StockingerCaetano Reis e SousaLight MicroscopyExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Copy number architectures define treatment-mediated selection of lethal prostate cancer clones Authors (24) AM Mahedi Hasan Paolo Cremaschi Daniel Wetterskog Anuradha Jayaram Stephen Q Wong Scott Williams[...]Charles Swanton Mariam Jamal-Hanjani Stefano Lise Shahneen Sandhu Gerhardt Attard Nature Communications Published 10 August 2023 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonPeter ParkerExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border Authors (7) Alexandre P Thiery Ailin Leticia Buzzi Eva HamrudChris CheshireNicholas LuscombeJames Briscoe Andrea Streit eLife Published 2 August 2023 Crick labs/ facilitiesNicholas LuscombeJames BriscoeAdvanced SequencingFull details Gastruloid-derived primordial germ cell-like cells develop dynamically within integrated tissues Authors (5) Christopher B Cooke Christopher BarringtonPeter Baillie-Benson Jennifer NicholsNaomi Moris Development Published 1 September 2023 Crick labs/ facilitiesNaomi MorisBioinformatics and BiostatisticsLight MicroscopyFlow CytometryAdvanced SequencingFull details Control of protein synthesis through mRNA pseudouridylation by dyskerin Authors (10) Chiara Pederiva Davide M Trevisan Dimitra Peirasmaki Shan Chen Sharon A Savage Ola LarssonJernej Ule Laura Baranello Federico Agostini Marianne Farnebo Science advances Published 28 July 2023 Crick labs/ facilitiesJernej UleAdvanced SequencingFull details The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes Authors (11)Anastasiya KazachenkaJane LoongJan AttigGeorge YoungPiyali Ganguli Ginny Devonshire Nicola Grehan The OCCAMS ConsortiumFrancesca Ciccarelli Rebecca C FitzgeraldGeorge Kassiotis NAR Cancer Published 1 September 2023 Crick labs/ facilitiesGeorge KassiotisFrancesca CiccarelliBioinformatics and BiostatisticsScientific computingCell ServicesAdvanced SequencingFull details Type I interferons drive MAIT cell functions againstbacterial pneumonia Authors (12)Juan Carlos Lopez-Rodriguez Steven J Hancock Kelin LiStefania Crotta Christopher Barrington Alejandro Suárez-Bonnet[...] Jeffrey AubéAndreas Wack Paul Klenerman Jose A BengoecheaPatricia Barral Journal of Experimental Medicine Published 2 October 2023 Crick labs/ facilitiesAndreas WackPatricia BarralExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells Authors (8)Eloise LockyerFrancesca TorelliSimon ButterworthOk-Ryul Song Steven HowellAnne WestonPhil EastMoritz Treeck PLOS Biology Published 17 July 2023 Crick labs/ facilitiesMoritz TreeckProteomicsHigh Throughput ScreeningElectron MicroscopyBioinformatics and BiostatisticsCell ServicesAdvanced SequencingFull details Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network Authors (8)Ana Martinez Riano Shenshen WangStefan BoeingSophie MinoughanAntonio Casal Katelyn M Spillane Burkhard LudewigPavel Tolar Nature Immunology Published 1 August 2023 Crick labs/ facilitiesPavel TolarStructural BiologyLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details Pagination First page First Previous page Previous Page 1 Page 2 Page 3 Current page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details
Endothelial AHR activity prevents lung barrier disruption in viral infection Authors (13)Jack MajorStefania CrottaKatja Finsterbusch Probir ChakravartyKathleen ShahBruno Frederico[...] Lucy Meader Alejandro Suarez-BonnetSimon PriestnallBrigitta StockingerAndreas Wack Nature Published 28 September 2023 Crick labs/ facilitiesAndreas WackGitta StockingerCaetano Reis e SousaLight MicroscopyExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Copy number architectures define treatment-mediated selection of lethal prostate cancer clones Authors (24) AM Mahedi Hasan Paolo Cremaschi Daniel Wetterskog Anuradha Jayaram Stephen Q Wong Scott Williams[...]Charles Swanton Mariam Jamal-Hanjani Stefano Lise Shahneen Sandhu Gerhardt Attard Nature Communications Published 10 August 2023 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonPeter ParkerExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border Authors (7) Alexandre P Thiery Ailin Leticia Buzzi Eva HamrudChris CheshireNicholas LuscombeJames Briscoe Andrea Streit eLife Published 2 August 2023 Crick labs/ facilitiesNicholas LuscombeJames BriscoeAdvanced SequencingFull details
Gastruloid-derived primordial germ cell-like cells develop dynamically within integrated tissues Authors (5) Christopher B Cooke Christopher BarringtonPeter Baillie-Benson Jennifer NicholsNaomi Moris Development Published 1 September 2023 Crick labs/ facilitiesNaomi MorisBioinformatics and BiostatisticsLight MicroscopyFlow CytometryAdvanced SequencingFull details
Control of protein synthesis through mRNA pseudouridylation by dyskerin Authors (10) Chiara Pederiva Davide M Trevisan Dimitra Peirasmaki Shan Chen Sharon A Savage Ola LarssonJernej Ule Laura Baranello Federico Agostini Marianne Farnebo Science advances Published 28 July 2023 Crick labs/ facilitiesJernej UleAdvanced SequencingFull details
The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes Authors (11)Anastasiya KazachenkaJane LoongJan AttigGeorge YoungPiyali Ganguli Ginny Devonshire Nicola Grehan The OCCAMS ConsortiumFrancesca Ciccarelli Rebecca C FitzgeraldGeorge Kassiotis NAR Cancer Published 1 September 2023 Crick labs/ facilitiesGeorge KassiotisFrancesca CiccarelliBioinformatics and BiostatisticsScientific computingCell ServicesAdvanced SequencingFull details
Type I interferons drive MAIT cell functions againstbacterial pneumonia Authors (12)Juan Carlos Lopez-Rodriguez Steven J Hancock Kelin LiStefania Crotta Christopher Barrington Alejandro Suárez-Bonnet[...] Jeffrey AubéAndreas Wack Paul Klenerman Jose A BengoecheaPatricia Barral Journal of Experimental Medicine Published 2 October 2023 Crick labs/ facilitiesAndreas WackPatricia BarralExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells Authors (8)Eloise LockyerFrancesca TorelliSimon ButterworthOk-Ryul Song Steven HowellAnne WestonPhil EastMoritz Treeck PLOS Biology Published 17 July 2023 Crick labs/ facilitiesMoritz TreeckProteomicsHigh Throughput ScreeningElectron MicroscopyBioinformatics and BiostatisticsCell ServicesAdvanced SequencingFull details
Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network Authors (8)Ana Martinez Riano Shenshen WangStefan BoeingSophie MinoughanAntonio Casal Katelyn M Spillane Burkhard LudewigPavel Tolar Nature Immunology Published 1 August 2023 Crick labs/ facilitiesPavel TolarStructural BiologyLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details