Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Advanced Sequencing Advanced Sequencing : Publications Lab contentLab contentIn this section Overview Applications Equipment Publications Members A HiSeq flowcell. Credit: Fiona Byrne. Toggle to view hero caption Publications Displaying 51 - 60 of 350Last updated : 23 April 2024 02:40 Evolutionary characterization of lung adenocarcinoma morphology in TRACERx Authors (53)Takahiro Karasaki David A Moore Selvaraju Veeriah Cristina Naceur-Lombardelli Antonia Toncheva Neil Magno[...] Andrew G Nicholson TRACERx Consortium Nicholas McGranahanCharles Swanton Mariam Jamal-Hanjani Nature Medicine Published 1 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Genomic-transcriptomic evolution in lung cancer and metastasis Authors (47) Carlos Martínez-Ruiz James RM Black Clare Puttick Mark S HillJonas DemeulemeesterElizabeth Larose Cadieux[...] Peter Van Loo Mariam Jamal-Hanjani TRACERx Consortium Charles Swanton Nicholas McGranahan Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details The evolution of lung cancer and impact of subclonal selection in TRACERx Authors (81)Alexander FrankellMichelle DietzenMaise Al BakirEmilia LimTakahiro KarasakiSophie Ward[...] Simone Zaccaria TRACERx Consortium Mariam Jamal-Hanjani Nicholas McGranahanCharles Swanton Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details The evolution of non-small cell lung cancer metastases in TRACERx Authors (66)Maise Al BakirAriana Huebner Carlos Martínez-Ruiz Kristiana GrigoriadisTom Watkins Oriol Pich[...] Simone Zaccaria TRACERx Consortium Mariam Jamal-Hanjani Nicholas McGranahanCharles Swanton Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details Generation of an MTM1-mutant iPSC line (CRICKi008-A) from an individual with X-linked myotubular myopathy (XLMTM) Authors (5)Liani Gasparini DevitoValentina Lionello Francesco MuntoniFrancesco Saverio TedescoLyn Healy Stem Cell Research Published 1 June 2023 Crick labs/ facilitiesFrancesco Saverio TedescoHuman Embryonic Stem CellCell ServicesAdvanced SequencingFull details Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation Authors (12)Oana PaunYu Xuan Tan Harshil Patel Stephanie StrohbueckerAvinash GhanateClementina Cobolli Gigli[...]Lina GerontogianniRobert GoldstoneSiew-Lan AngFrancois GuillemotCristina Dias Genes and Development Published 1 March 2023 Crick labs/ facilitiesFrancois GuillemotBioinformatics and BiostatisticsProteomicsLight MicroscopyHuman Embryonic Stem CellFlow CytometryAdvanced SequencingFull details The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Authors (16)Ambra Natalini Sonia Simonetti Gabriele Favaretto Lorenzo Lucantonio Giovanna PeruzziMiguel Munoz-Ruiz[...] Antonella Folgori Alfredo Nicosia Angela SantoniAdrian Hayday Francesca Di Rosa Frontiers in Immunology Published 14 February 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation Authors (8)Stefania Crotta Matteo VillaJack MajorKatja FinsterbuschMiriam Llorian Sopena Peter Carmeliet Joerg BuescherAndreas Wack Nature Communications Published 13 February 2023 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Pagination First page First Previous 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Evolutionary characterization of lung adenocarcinoma morphology in TRACERx Authors (53)Takahiro Karasaki David A Moore Selvaraju Veeriah Cristina Naceur-Lombardelli Antonia Toncheva Neil Magno[...] Andrew G Nicholson TRACERx Consortium Nicholas McGranahanCharles Swanton Mariam Jamal-Hanjani Nature Medicine Published 1 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Genomic-transcriptomic evolution in lung cancer and metastasis Authors (47) Carlos Martínez-Ruiz James RM Black Clare Puttick Mark S HillJonas DemeulemeesterElizabeth Larose Cadieux[...] Peter Van Loo Mariam Jamal-Hanjani TRACERx Consortium Charles Swanton Nicholas McGranahan Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
The evolution of lung cancer and impact of subclonal selection in TRACERx Authors (81)Alexander FrankellMichelle DietzenMaise Al BakirEmilia LimTakahiro KarasakiSophie Ward[...] Simone Zaccaria TRACERx Consortium Mariam Jamal-Hanjani Nicholas McGranahanCharles Swanton Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
The evolution of non-small cell lung cancer metastases in TRACERx Authors (66)Maise Al BakirAriana Huebner Carlos Martínez-Ruiz Kristiana GrigoriadisTom Watkins Oriol Pich[...] Simone Zaccaria TRACERx Consortium Mariam Jamal-Hanjani Nicholas McGranahanCharles Swanton Nature Published 20 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonGeorge KassiotisFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Lung adenocarcinoma promotion by air pollutants Authors (72)William HillEmilia LimClare Weeden Claudia Lee Marcellus Augustine Kezhong Chen[...] Kevin Litchfield TRACERx Consortium James DeGregori Mariam Jamal-HanjaniCharles Swanton Nature Published 6 April 2023 Crick labs/ facilitiesPeter Van LooCharles SwantonIlaria MalanchiGeorge KassiotisJulian DownwardFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingLight MicroscopyBiological Research FacilityFull details
Generation of an MTM1-mutant iPSC line (CRICKi008-A) from an individual with X-linked myotubular myopathy (XLMTM) Authors (5)Liani Gasparini DevitoValentina Lionello Francesco MuntoniFrancesco Saverio TedescoLyn Healy Stem Cell Research Published 1 June 2023 Crick labs/ facilitiesFrancesco Saverio TedescoHuman Embryonic Stem CellCell ServicesAdvanced SequencingFull details
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation Authors (12)Oana PaunYu Xuan Tan Harshil Patel Stephanie StrohbueckerAvinash GhanateClementina Cobolli Gigli[...]Lina GerontogianniRobert GoldstoneSiew-Lan AngFrancois GuillemotCristina Dias Genes and Development Published 1 March 2023 Crick labs/ facilitiesFrancois GuillemotBioinformatics and BiostatisticsProteomicsLight MicroscopyHuman Embryonic Stem CellFlow CytometryAdvanced SequencingFull details
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Authors (16)Ambra Natalini Sonia Simonetti Gabriele Favaretto Lorenzo Lucantonio Giovanna PeruzziMiguel Munoz-Ruiz[...] Antonella Folgori Alfredo Nicosia Angela SantoniAdrian Hayday Francesca Di Rosa Frontiers in Immunology Published 14 February 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details
Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation Authors (8)Stefania Crotta Matteo VillaJack MajorKatja FinsterbuschMiriam Llorian Sopena Peter Carmeliet Joerg BuescherAndreas Wack Nature Communications Published 13 February 2023 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
