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Bioinformatics and Biostatistics : Publications

Publications

Zatreanu,Diana; Han,Zhong; Mitter,Richard; Tumini,Emanuela; Williams,Hannah; Gregersen,Lea; et al

Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability

Molecular Cell (2019) 76, Epub ahead of print

Young,Joanna; Dominicus,Caia; Wagener,Jeanette; Butterworth,Simon; Ye,Xingda; Kelly,Gavin; et al

A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice.

Nature Communications (2019) 10, 3963

Ombrato,Luigi; Nolan,Emma; Kurelac,Ivana; Mavousian,Antranik; Bridgeman,Victoria Louise; Heinze,Ivonne; et al

Metastatic-niche labelling reveals parenchymal cells with stem features.

Nature (2019) 572, 603-608

Rohlwink,Ursula K; Figaji,Anthony; Wilkinson,Katalin A; Horswell,Stuart; Sesay,Abdul K; Deffur,Armin; et al

Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity.

Nature Communications (2019) 10, 3767

Serafini,Agnese; Tan,Lendl; Horswell,Stuart; Howell,Steven; Greenwood,Daniel J; Hunt,Deborah M; et al

Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism.

Molecular Microbiology (2019) Epub ahead of print

Omenetti,Sara; Bussi,Claudio; Metidji,Amina; Iseppon,Andrea; Lee,Sunjae; Tolaini,Mauro; et al

The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells.

Immunity (2019) 51, 77-89.e6

Diring,Jessica; Mouilleron,Stephane; McDonald,Neil Q; Treisman,Richard

RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability.

Nature Cell Biology (2019) 21, 845-855

Greenwood,Daniel J; Dos Santos,Mariana Silva; Huang,Song; Russell,Matthew RG; Collinson,Lucy M; MacRae,James I; et al

Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages.

Science (2019) 364, 1279-1282

Burnham,Daniel R; Kose,Hazal B; Hoyle,Rebecca B; Yardimci,Hasan

The mechanism of DNA unwinding by the eukaryotic replicative helicase.

Nature Communications (2019) 10, 2159

Wallbank,Bethan A; Dominicus,Caia S; Broncel,Malgorzata; Legrave,Nathalie; MacRae,James I; Staines,Henry M; et al

Characterisation of the Toxoplasma gondii tyrosine transporter and its phosphorylation by the calcium-dependent protein kinase 3

Molecular Microbiology (2019) 111, 1167-1181

Chakrabarti,Anob M; Henser-Brownhill,Tristan; Monserrat,Josep; Poetsch,Anna R; Luscombe,Nicholas M; Scaffidi,Paola

Target-specific precision of CRISPR-mediated genome editing

Molecular Cell (2019) 73, 699-713.e6

Poetsch,Anna R; Boulton,Simon J; Luscombe,Nicholas M

Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis

Genome Biology (2018) 19, 215