Publications

Eder,Noreen Roncaroli,Federico Dolmart,Marie-Charlotte Horswell,Stuart Andreiuolo,Felipe Flynn,Helen et al

YAP1/TAZ drives ependymoma-like tumour formation in mice

Nature Communications (2020) 11, 2380

Toboso-Navasa,Amparo Gunawan,Arief Morlino,Giulia Nakagawa,Rinako Taddei,Andrea Damry,Djamil et al

Restriction of memory B cell differentiation at the germinal center B cell positive selection stage

Journal of Experimental Medicine (2020) 217, e20191933

Monin,L Ushakov,DS Arnesen,H Bah,N Jandke,A Muñoz-Ruiz,M et al

γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis

Mucosal Immunology (2020) Epub ahead of print

Litchfield,Kevin Stanislaw,Stacey Spain,Lavinia Gallegos,Lisa L Rowan,Andrew Schnidrig,Desiree et al

Representative sequencing: Unbiased sampling of solid tumor tissue

Cell Reports (2020) 31, 107550

Waclawiczek,Alexander Hamilton,Ashley Rouault-Pierre,Kevin Abarrategi,Ander Albornoz,Manuel Garcia Miraki-Moud,Farideh et al

Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia

Journal of Clinical Investigation (2020) Epub ahead of print

Gunne-Braden,Alexandra Sullivan,Adrienne Gharibi,Borzo Sheriff,Rahuman SM Maity,Alok Wang,Yi-Fang et al

GATA3 mediates a fast, irreversible commitment to BMP4-driven differentiation in human embryonic stem cells

Cell Stem Cell (2020) Epub ahead of print

Morales Torres,Cristina Wu,Mary Y Hobor,Sebastijan Wainwright,Elanor N Martin,Matthew J Patel,Harshil et al

Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

Nature Communications (2020) 11, 1792

Liu,Hon Wing Bouchoux,Céline Panarotto,Mélanie Kakui,Yasutaka Patel,Harshil Uhlmann,Frank

Division of labor between PCNA loaders in DNA replication and sister chromatid cohesion establishment

Molecular Cell (2020) Epub ahead of print

Fan,Z Devlin,JR Hogg,SJ Doyle,MA Harrison,PF Todorovski,I et al

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

Science Advances (2020) 6, eaaz5041

Moreira-Teixeira,Lúcia Tabone,Olivier Graham,Christine M Singhania,Akul Stavropoulos,Evangelos Redford,Paul S et al

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis

Nature Immunology (2020) 21, 464-476

Tufegdžić Vidaković,Ana Mitter,Richard Kelly,Gavin P Neumann,Michelle Harreman,Michelle Rodríguez-Martínez,Marta et al

Regulation of the RNAPII pool is integral to the DNA damage response

Cell (2020) 180, 1245-1261.e21

Tambalo,Monica Mitter,Richard Wilkinson,David G

A single cell transcriptome atlas of the developing zebrafish hindbrain

Development (2020) 147, dev.184143

López,Saioa Lim,Emilia L Horswell,Stuart Haase,Kerstin Huebner,Ariana Dietzen,Michelle et al

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

Nature Genetics (2020) 52, 283-293

Montagner,Marco Bhome,Rahul Hooper,Steven Chakravarty,Probir Qin,Xiao Sufi,Jahangir et al

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

Nature Cell Biology (2020) 22, 289-296

Obata,Yuuki Castaño,Álvaro Boeing,Stefan Bon-Frauches,Ana Carina Fung,Candice Fallesen,Todd et al

Using TTchem-seq for profiling nascent transcription and measuring transcript elongation

Nature Protocols (2020) 15, 604-627

Aegerter,Helena Kulikauskaite,Justina Crotta,Stefania Patel,Harshil Kelly,Gavin Hessel,Edith M et al

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

Nature Immunology (2020) 21, 145-157

Park,Danielle Wershof,Esther Boeing,Stefan Labernadie,Anna Jenkins,Robert P George,Samantha et al

Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions

Nature Materials (2020) 19, 227-238

Blagih,Julianna Zani,Fabio Chakravarty,Probir Hennequart,Marc Pilley,Steven Hobor,Sebastijan et al

Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses

Cell Reports (2020) 30, 481-496.e6

Ellis,R Tang,D Nasr,B Greenwood,A McConnell,A Anagnostou,ME et al

Epidermal autophagy and beclin 1 regulator 1 and loricrin: a paradigm shift in the prognostication and stratification of the American Joint Committee on Cancer stage I melanomas

British Journal of Dermatology (2020) 182, 156-165

Jimeno,Rebeca Lebrusant-Fernandez,Marta Margreitter,Christian Lucas,Beth Veerapen,Natacha Kelly,Gavin et al

Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells

Elife (2019) 8, e51663

Touati,Sandra A Hofbauer,Lorena Jones,Andrew W Snijders,Ambrosius P Kelly,Gavin Uhlmann,Frank

Cdc14 and PP2A phosphatases cooperate to shape phosphoproteome dynamics during mitotic exit

Cell Reports (2019) 29, 2105-2119.e4

Biswas,Dhruva Birkbak,Nicolai J Rosenthal,Rachel Hiley,Crispin T Lim,Emilia L Papp,Krisztian et al

A clonal expression biomarker associates with lung cancer mortality

Nature Medicine (2019) 25, 1540-1548

Zatreanu,Diana Han,Zhong Mitter,Richard Tumini,Emanuela Williams,Hannah Gregersen,Lea et al

Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability

Molecular Cell (2019) 76, 57-69.e9

Serafini,Agnese Tan,Lendl Horswell,Stuart Howell,Steven Greenwood,Daniel J Hunt,Deborah M et al

Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism

Molecular Microbiology (2019) 112, 1284-1307

Molina-Arcas,Miriam Moore,Christopher Rana,Sareena van Maldegem,Febe Mugarza,Edurne Romero-Clavijo,Pablo et al

Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer

Science Translational Medicine (2019) 11, eaaw7999

Young,Joanna Dominicus,Caia Wagener,Jeanette Butterworth,Simon Ye,Xingda Kelly,Gavin et al

A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice

Nature Communications (2019) 10, 3963

Mortimer,Thomas Wainwright,Elanor N Patel,Harshil Siow,Bernard M Jaunmuktane,Zane Brandner,Sebastian et al

Redistribution of EZH2 promotes malignant phenotypes by rewiring developmental programmes

EMBO Reports (2019) 20, e48155

Ombrato,Luigi Nolan,Emma Kurelac,Ivana Mavousian,Antranik Bridgeman,Victoria Louise Heinze,Ivonne et al

Metastatic-niche labelling reveals parenchymal cells with stem features

Nature (2019) 572, 603-608

Rohlwink,Ursula K Figaji,Anthony Wilkinson,Katalin A Horswell,Stuart Sesay,Abdul K Deffur,Armin et al

Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

Nature Communications (2019) 10, 3767

Clough,Barbara Finethy,Ryan Khan,Rabia T Fisch,Daniel Jordan,Sarah Patel,Harshil et al

C57BL/6 and 129 inbred mouse strains differ in Gbp2 and Gbp2b expression in response to inflammatory stimuli in vivo

Wellcome Open Research (2019) 4, 124

Omenetti,Sara Bussi,Claudio Metidji,Amina Iseppon,Andrea Lee,Sunjae Tolaini,Mauro et al

The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells

Immunity (2019) 51, 77-89.e6

Lionarons,Daniël A Hancock,David C Rana,Sareena East,Philip Moore,Christopher Murillo,Miguel M et al

RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance

Cancer Cell (2019) 36, 68-83.e9

Macpherson,Jamie A Theisen,Alina Masino,Laura Fets,Louise Driscoll,Paul C Encheva,Vesela et al

Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

Elife (2019) 8, e45068

Bradley,Konrad C Finsterbusch,Katja Schnepf,Daniel Crotta,Stefania Llorian,Miriam Davidson,Sophia et al

Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection

Cell Reports (2019) 28, 245-256.e4

Sellers,Katherine Allen,Thaddeus D Bousamra,Michael Tan,JinLian Méndez-Lucas,Andrés Lin,Wei et al

Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes

British Journal of Cancer (2019) 121, 51-64

Singhania,Akul Graham,Christine M Gabryšová,Leona Moreira-Teixeira,Lúcia Stavropoulos,Evangelos Pitt,Jonathan M et al

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

Nature Communications (2019) 10, 2887

Gregersen,Lea H Mitter,Richard Ugalde,Alejandro P Nojima,Takayuki Proudfoot,Nicholas J Agami,Reuven et al

SCAF4 and SCAF8, mRNA anti-terminator proteins

Cell (2019) 177, 1797-1813.e18

Muñoz,Sofía Minamino,Masashi Casas-Delucchi,Corella S Patel,Harshil Uhlmann,Frank

A role for chromatin remodeling in cohesin loading onto chromosomes

Molecular Cell (2019) 74, 664-673.e5

Judith,Delphine Jefferies,Harold BJ Boeing,Stefan Frith,David Snijders,Ambrosius P Tooze,Sharon A

ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIβ

Journal of Cell Biology (2019) 218, 1634-1652

Moncho-Amor,Verónica Pintado-Berninches,Laura Ibañez de Cáceres,Inmaculada Martín-Villar,Ester Quintanilla,Miguel Chakravarty,Probir et al

Role of Dusp6 phosphatase as a tumor suppressor in non-small cell lung cancer

International Journal of Molecular Sciences (2019) 20, 2036

Vidakovic,Ana Tufegdzic Harreman,Michelle Dirac-Svejstrup,A Barbara Boeing,Stefan Roy,Anindya Encheva,Vesela et al

Analysis of RNA polymerase II ubiquitylation and proteasomal degradation

Methods (2019) 159, 146-156

Rosenthal,Rachel Cadieux,Elizabeth Larose Salgado,Roberto Bakir,Maise Al Moore,David A Hiley,Crispin T et al

Neoantigen-directed immune escape in lung cancer evolution

Nature (2019) 567, 479-485

Cabeza-Cabrerizo,Mar van Blijswijk,Janneke Wienert,Stephan Heim,Daniel Jenkins,Robert P Chakravarty,Probir et al

Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors

Science Immunology (2019) 4, eaaw1941

Gómez-González,Belén Patel,Harshil Early,Anne Diffley,John FX

Rpd3L contributes to the DNA damage sensitivity of Saccharomyces cerevisiae checkpoint mutants

Genetics (2019) 211, 503-513

Ruiz,E Josue Diefenbacher,Markus E Nelson,Jessica K Sancho,Rocio Pucci,Fabio Chakraborty,Atanu et al

LUBAC determines chemotherapy resistance in squamous cell lung cancer

Journal of Experimental Medicine (2019) 216, 450-465

Deiss,Katharina Lockwood,Nicola Howell,Michael Segeren,Hendrika Alida Saunders,Rebecca E Chakravarty,Probir et al

A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest

Nucleic Acids Research (2019) 47, 2906-2921

Talavera-López,Carlos Capuccini,Barbara Mitter,Richard Lin,Jing-wen Langhorne,Jean

Transcriptomes of microglia in experimental cerebral malaria in mice in the presence and absence of Type I Interferon signaling

BMC Research Notes (2018) 11, 913

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Publications

YAP1/TAZ drives ependymoma-like tumour formation in mice

Restriction of memory B cell differentiation at the germinal center B cell positive selection stage

γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis

Representative sequencing: Unbiased sampling of solid tumor tissue

Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia

GATA3 mediates a fast, irreversible commitment to BMP4-driven differentiation in human embryonic stem cells

Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

Division of labor between PCNA loaders in DNA replication and sister chromatid cohesion establishment

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis

Regulation of the RNAPII pool is integral to the DNA damage response

A single cell transcriptome atlas of the developing zebrafish hindbrain

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

Neuronal programming by microbiota regulates intestinal physiology

The nf-core framework for community-curated bioinformatics pipelines

Greb1 is required for axial elongation and segmentation in vertebrate embryos

Using TTchem-seq for profiling nascent transcription and measuring transcript elongation

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions

Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses

Epidermal autophagy and beclin 1 regulator 1 and loricrin: a paradigm shift in the prognostication and stratification of the American Joint Committee on Cancer stage I melanomas

Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells

Cdc14 and PP2A phosphatases cooperate to shape phosphoproteome dynamics during mitotic exit

A clonal expression biomarker associates with lung cancer mortality

Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability

Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism

Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer

A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice

Redistribution of EZH2 promotes malignant phenotypes by rewiring developmental programmes

Metastatic-niche labelling reveals parenchymal cells with stem features

Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

C57BL/6 and 129 inbred mouse strains differ in Gbp2 and Gbp2b expression in response to inflammatory stimuli in vivo

The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells

RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance

Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection

Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

SCAF4 and SCAF8, mRNA anti-terminator proteins

A role for chromatin remodeling in cohesin loading onto chromosomes

ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIβ

Role of Dusp6 phosphatase as a tumor suppressor in non-small cell lung cancer

Analysis of RNA polymerase II ubiquitylation and proteasomal degradation

Neoantigen-directed immune escape in lung cancer evolution

Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors

Rpd3L contributes to the DNA damage sensitivity of Saccharomyces cerevisiae checkpoint mutants

LUBAC determines chemotherapy resistance in squamous cell lung cancer

A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest

Transcriptomes of microglia in experimental cerebral malaria in mice in the presence and absence of Type I Interferon signaling

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