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Breadcrumb Bioinformatics and Biostatistics Bioinformatics and Biostatistics : Publications Lab contentLab contentIn this section Overview Publications Members Bioinformatic visualisation of protein binding along a human chromosome, courtesy of Federico Agostini and Nick Luscombe. Toggle to view hero caption Publications Displaying 1 - 10 of 349Last updated : 17 May 2022 03:02 Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation Authors (7)Robert Blassberg Harshil Patel Thomas Watson Mina GoutiVicki Metzis M Joaquina DelásJames Briscoe Nature Cell Biology Published 12 May 2022 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Authors (19)Jessica Nelson May Zaw ThinTheo Evan Steven HowellMary WuBruna Coelho Almeida[...]Bram Snijders Andreas Prachalias Yoh Zen Debashis SarkerAxel Behrens Nature Communications Published 19 April 2022 Crick labs/ facilitiesPeter RatcliffeAxel BehrensProteomicsMetabolomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Cell-intrinsic aryl hydrocarbon receptor signalling is required for the resolution of injury-induced colonic stem cells Authors (15)Kathleen ShahMurali Maradana M Joaquina Delàs Amina Metidji Frederike Graelmann Miriam Llorian[...]Gavin KellyChris Cheshire Deendyal Bhurta Sandip B BharateBrigitta Stockinger Nature Communications Published 5 April 2022 Crick labs/ facilitiesGitta StockingerNicholas LuscombeJames BriscoeBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro Authors (7)George Gentsch Richard MitterCamille BouissouLyn Healy Ana Hernandez RodriguezJim Smith Andreia S Bernardo Stem Cell Reports Published 12 April 2022 Crick labs/ facilitiesJim SmithHuman Embryonic Stem CellBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma Authors (17) Annalisa D'AvolaNathalie LegraveMylene Tajan Probir Chakravarty Ryan L Shearer Hamish W King[...]James Macrae John G GribbenDinis CaladoKaren VousdenJohn Riches Journal of Clinical Investigation Published 2 May 2022 Crick labs/ facilitiesKaren VousdenDinis CaladoMetabolomicsBioinformatics and BiostatisticsFull details A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses Authors (7)Davide Coda Harshil PatelIlaria Gori Tessa E GaarenstroomOk-Ryul SongMichael HowellCaroline Hill Journal of Cell Science Published 15 April 2022 Crick labs/ facilitiesCaroline HillHigh Throughput ScreeningBioinformatics and BiostatisticsGenomics/Equipment ParkFlow CytometryCell ServicesAdvanced SequencingFull details Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization Authors (12)Emma NolanVicky BridgemanLuigi OmbratoAdam KaroutasNick Rabas Celine Angeli Natascha Sewneth[...] Felipe Silva Rodrigues Stuart HorswellPeter Faull Rebecca CarterIlaria Malanchi Nature Cancer Published 1 February 2022 Crick labs/ facilitiesIlaria MalanchiProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance Authors (23) Patrizia Romani Nunzia Nirchio Mattia Arboit Vito Barbieri Anna Tosi Federica Michielin[...] Stephen L Archer Paolo De Coppi Antonio Rosato Graziano Martello Sirio Dupont Nature Cell Biology Published 1 February 2022 Crick labs/ facilitiesBioinformatics and BiostatisticsFull details Normality sensing licenses local T cells for innate-like tissue surveillance Authors (7) Duncan R McKenzie Rosie Hart Nourdine Bah Dmitry S Ushakov Miguel Muñoz-Ruiz Regina FeederleAdrian Hayday Nature Immunology Published 1 March 2022 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsLight MicroscopyGenomics/Equipment ParkFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo Authors (12)Tim Humpton Andreas K Hock Christos Kiourtis Marco De Donatis Frédéric Fercoq Colin Nixon[...] Douglas Strathdee Leo M Carlin Thomas G Bird Karen BlythKaren Vousden Science Signaling Published 8 February 2022 Crick labs/ facilitiesKaren VousdenBioinformatics and BiostatisticsFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation Authors (7)Robert Blassberg Harshil Patel Thomas Watson Mina GoutiVicki Metzis M Joaquina DelásJames Briscoe Nature Cell Biology Published 12 May 2022 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Authors (19)Jessica Nelson May Zaw ThinTheo Evan Steven HowellMary WuBruna Coelho Almeida[...]Bram Snijders Andreas Prachalias Yoh Zen Debashis SarkerAxel Behrens Nature Communications Published 19 April 2022 Crick labs/ facilitiesPeter RatcliffeAxel BehrensProteomicsMetabolomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details
Cell-intrinsic aryl hydrocarbon receptor signalling is required for the resolution of injury-induced colonic stem cells Authors (15)Kathleen ShahMurali Maradana M Joaquina Delàs Amina Metidji Frederike Graelmann Miriam Llorian[...]Gavin KellyChris Cheshire Deendyal Bhurta Sandip B BharateBrigitta Stockinger Nature Communications Published 5 April 2022 Crick labs/ facilitiesGitta StockingerNicholas LuscombeJames BriscoeBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro Authors (7)George Gentsch Richard MitterCamille BouissouLyn Healy Ana Hernandez RodriguezJim Smith Andreia S Bernardo Stem Cell Reports Published 12 April 2022 Crick labs/ facilitiesJim SmithHuman Embryonic Stem CellBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details
PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma Authors (17) Annalisa D'AvolaNathalie LegraveMylene Tajan Probir Chakravarty Ryan L Shearer Hamish W King[...]James Macrae John G GribbenDinis CaladoKaren VousdenJohn Riches Journal of Clinical Investigation Published 2 May 2022 Crick labs/ facilitiesKaren VousdenDinis CaladoMetabolomicsBioinformatics and BiostatisticsFull details
A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses Authors (7)Davide Coda Harshil PatelIlaria Gori Tessa E GaarenstroomOk-Ryul SongMichael HowellCaroline Hill Journal of Cell Science Published 15 April 2022 Crick labs/ facilitiesCaroline HillHigh Throughput ScreeningBioinformatics and BiostatisticsGenomics/Equipment ParkFlow CytometryCell ServicesAdvanced SequencingFull details
Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization Authors (12)Emma NolanVicky BridgemanLuigi OmbratoAdam KaroutasNick Rabas Celine Angeli Natascha Sewneth[...] Felipe Silva Rodrigues Stuart HorswellPeter Faull Rebecca CarterIlaria Malanchi Nature Cancer Published 1 February 2022 Crick labs/ facilitiesIlaria MalanchiProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance Authors (23) Patrizia Romani Nunzia Nirchio Mattia Arboit Vito Barbieri Anna Tosi Federica Michielin[...] Stephen L Archer Paolo De Coppi Antonio Rosato Graziano Martello Sirio Dupont Nature Cell Biology Published 1 February 2022 Crick labs/ facilitiesBioinformatics and BiostatisticsFull details
Normality sensing licenses local T cells for innate-like tissue surveillance Authors (7) Duncan R McKenzie Rosie Hart Nourdine Bah Dmitry S Ushakov Miguel Muñoz-Ruiz Regina FeederleAdrian Hayday Nature Immunology Published 1 March 2022 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsLight MicroscopyGenomics/Equipment ParkFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo Authors (12)Tim Humpton Andreas K Hock Christos Kiourtis Marco De Donatis Frédéric Fercoq Colin Nixon[...] Douglas Strathdee Leo M Carlin Thomas G Bird Karen BlythKaren Vousden Science Signaling Published 8 February 2022 Crick labs/ facilitiesKaren VousdenBioinformatics and BiostatisticsFull details
