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Breadcrumb Bioinformatics and Biostatistics Bioinformatics and Biostatistics : Publications Lab contentLab contentIn this section Overview Publications Members Bioinformatic visualisation of protein binding along a human chromosome, courtesy of Federico Agostini and Nick Luscombe. Toggle to view hero caption Publications Displaying 1 - 10 of 445Last updated : 24 April 2024 02:26 CRISPR-Cas9 screening identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer Authors (16)Jesse Boumelha Andrea de Castro Nourdine Bah Hongui ChaSophie de CarneSareena Rana[...]Phil East Kevin Litchfield Se-Hoon LeeMiriam Molina ArcasJulian Downward Cancer Research Published 18 April 2024 Crick labs/ facilitiesJulian DownwardBioinformatics and BiostatisticsScientific computingFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis Authors (16)Marisol Alvarez MartinezLuke CoxClaire F PearsonWilliam BranchettProbir ChakravartyXuemei Wu[...]Alejandro Suárez-BonnetAnna MikolajczakJames BriscoeFiona PowrieAnne O'Garra Nature Immunology Published 12 April 2024 Crick labs/ facilitiesAnne O’GarraJames BriscoeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFlow CytometryBiological Research FacilityAdvanced SequencingFull details Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TMBIM4 safeguards IgG1+ GC B cell-positive selection Authors (14) Lingling Zhang Amparo Toboso-Navasa Arief Gunawan Abdouramane CamaraRinako NakagawaKatja Finsterbusch[...] Martin EilersAndreas WackPavel Tolar Kai-Michael ToellnerDinis Calado Science Immunology Published 5 April 2024 Crick labs/ facilitiesAndreas WackPavel TolarDinis CaladoBioinformatics and BiostatisticsStructural BiologyLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details FOXL2 interaction with different binding partners regulates the dynamics of ovarian development Authors (7)Roberta MigaleMichelle Neumann Richard MitterMahmoud-Reza Rafiee Sophie WoodJessica OlsenRobin Lovell-Badge Science advances Published 22 March 2024 Crick labs/ facilitiesJernej UleRobin Lovell-BadgeGenetic Modification ServiceBioinformatics and BiostatisticsProteomicsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia Authors (11)Fiona Grimm Agustín AsuajeAakriti JainMariana Silva Dos Santos Jens KleinjungPatricia Figueiredo Nunes Stefanie GehrigLouise Fets Salihanur DariciJames MacraeDimitrios Anastasiou The EMBO Journal Published 16 April 2024 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsBioinformatics and BiostatisticsLight MicroscopyHigh Throughput ScreeningAdvanced SequencingFull details Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 23 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner Authors (11) Silvia Peripolli Leticia Meneguello Chiara Perrod Tanya Singh Harshil Patel Sazia T Rahman Koshiro Kiso Peter Thorpe Vincenzo Calvanese Cosetta Bertoli Robertus AM de Bruin Nature Communications Published 21 February 2024 Crick labs/ facilitiesBioinformatics and BiostatisticsAdvanced SequencingFull details Distinct ontogenetic lineages dictate cDC2 heterogeneity Authors (15)Carlos Munoz MinuttiCecile PiotMariana Pereira Da Costa Probir ChakravartyNeil RogersHector Huerga Encabo[...] Jean LanghorneDominique Bonnet Marc Dalod Elena TomaselloCaetano Reis e Sousa Nature Immunology Published 1 March 2024 Crick labs/ facilitiesCaetano Reis e SousaJean LanghorneGeorge KassiotisDominique BonnetBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected Authors (14) Kelvin M Kimenyi Mercy Y Akinyi Kioko MwikaliTegan Gilmore Shaban Mwangi Elisha Omer[...] George Obiero Philip Bejon Jean Langhorne Abdirahman Abdi Lynette Isabella Ochola-Oyier BMC Infectious Diseases Published 29 January 2024 Crick labs/ facilitiesJean LanghorneBioinformatics and BiostatisticsAdvanced SequencingFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
CRISPR-Cas9 screening identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer Authors (16)Jesse Boumelha Andrea de Castro Nourdine Bah Hongui ChaSophie de CarneSareena Rana[...]Phil East Kevin Litchfield Se-Hoon LeeMiriam Molina ArcasJulian Downward Cancer Research Published 18 April 2024 Crick labs/ facilitiesJulian DownwardBioinformatics and BiostatisticsScientific computingFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis Authors (16)Marisol Alvarez MartinezLuke CoxClaire F PearsonWilliam BranchettProbir ChakravartyXuemei Wu[...]Alejandro Suárez-BonnetAnna MikolajczakJames BriscoeFiona PowrieAnne O'Garra Nature Immunology Published 12 April 2024 Crick labs/ facilitiesAnne O’GarraJames BriscoeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TMBIM4 safeguards IgG1+ GC B cell-positive selection Authors (14) Lingling Zhang Amparo Toboso-Navasa Arief Gunawan Abdouramane CamaraRinako NakagawaKatja Finsterbusch[...] Martin EilersAndreas WackPavel Tolar Kai-Michael ToellnerDinis Calado Science Immunology Published 5 April 2024 Crick labs/ facilitiesAndreas WackPavel TolarDinis CaladoBioinformatics and BiostatisticsStructural BiologyLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
FOXL2 interaction with different binding partners regulates the dynamics of ovarian development Authors (7)Roberta MigaleMichelle Neumann Richard MitterMahmoud-Reza Rafiee Sophie WoodJessica OlsenRobin Lovell-Badge Science advances Published 22 March 2024 Crick labs/ facilitiesJernej UleRobin Lovell-BadgeGenetic Modification ServiceBioinformatics and BiostatisticsProteomicsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia Authors (11)Fiona Grimm Agustín AsuajeAakriti JainMariana Silva Dos Santos Jens KleinjungPatricia Figueiredo Nunes Stefanie GehrigLouise Fets Salihanur DariciJames MacraeDimitrios Anastasiou The EMBO Journal Published 16 April 2024 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsBioinformatics and BiostatisticsLight MicroscopyHigh Throughput ScreeningAdvanced SequencingFull details
Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 23 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner Authors (11) Silvia Peripolli Leticia Meneguello Chiara Perrod Tanya Singh Harshil Patel Sazia T Rahman Koshiro Kiso Peter Thorpe Vincenzo Calvanese Cosetta Bertoli Robertus AM de Bruin Nature Communications Published 21 February 2024 Crick labs/ facilitiesBioinformatics and BiostatisticsAdvanced SequencingFull details
Distinct ontogenetic lineages dictate cDC2 heterogeneity Authors (15)Carlos Munoz MinuttiCecile PiotMariana Pereira Da Costa Probir ChakravartyNeil RogersHector Huerga Encabo[...] Jean LanghorneDominique Bonnet Marc Dalod Elena TomaselloCaetano Reis e Sousa Nature Immunology Published 1 March 2024 Crick labs/ facilitiesCaetano Reis e SousaJean LanghorneGeorge KassiotisDominique BonnetBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected Authors (14) Kelvin M Kimenyi Mercy Y Akinyi Kioko MwikaliTegan Gilmore Shaban Mwangi Elisha Omer[...] George Obiero Philip Bejon Jean Langhorne Abdirahman Abdi Lynette Isabella Ochola-Oyier BMC Infectious Diseases Published 29 January 2024 Crick labs/ facilitiesJean LanghorneBioinformatics and BiostatisticsAdvanced SequencingFull details
