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Breadcrumb Bioinformatics and Biostatistics Bioinformatics and Biostatistics : Publications Lab contentLab contentIn this section Overview Publications Members Bioinformatic visualisation of protein binding along a human chromosome, courtesy of Federico Agostini and Nick Luscombe. Toggle to view hero caption Publications Displaying 81 - 90 of 445Last updated : 23 April 2024 02:53 The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX Authors (5)Alessia CaramelloChristophe Galichet Miriam Llorian SopenaRobin Lovell-BadgeKarine Rizzoti Developmental Neurobiology Published 1 October 2022 Crick labs/ facilitiesRobin Lovell-BadgeBioinformatics and BiostatisticsLight MicroscopyBiological Research FacilityAdvanced SequencingFull details SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export Authors (7)Ross HallAnabel GuedanMelvyn YapGeorge Young Ruth HarveyJonathan StoyeKate Bishop PLOS Pathogens Published 25 August 2022 Crick labs/ facilitiesJonathan StoyeKate BishopWorldwide Influenza CentreBioinformatics and BiostatisticsAdvanced SequencingFull details DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening Authors (16) Marianna Ioannou Dennis Hoving Iker Valle AramburuMia Temkin Nathalia M De Vasconcelos Theodora Dorita Tsourouktsoglou[...]Markus Ralser Sascha David Klaus Stahl Christian BodeVenizelos Papayannopoulos Nature Communications Published 9 August 2022 Crick labs/ facilitiesMarkus RalserVenizelos PapayannopoulosBioinformatics and BiostatisticsAdvanced SequencingFull details An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations Authors (26)Jesse BoumelhaSophie de Carne Emily K Law Pablo Romero-Clavijo Matthew A CoelhoKevin Ng[...]George KassiotisMiriam Molina ArcasCharles Swanton Reuben HarrisJulian Downward Cancer Research Published 1 October 2022 Crick labs/ facilitiesCharles SwantonGeorge KassiotisJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsScientific computingFlow CytometryCell ServicesBiological Research FacilityFull details ADAR1 averts fatal type I interferon induction by ZBP1 Authors (17) Huipeng Jiao Laurens Wachsmuth Simone Wolf Juliane Lohmann Masahiro Nagata Göksu Gökberk Kaya[...] Marco Prinz Christoph SchellGeorge YoungGeorge Kassiotis Manolis Pasparakis Nature Published 28 July 2022 Crick labs/ facilitiesGeorge KassiotisBioinformatics and BiostatisticsFull details Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers Authors (14)Edurne MugarzaFebe VanMaldegemJesse BoumelhaChristopher MooreSareena RanaMiriam Llorian Sopena[...] Pablo Romero-ClavijoKarishma ValandMegan ColeMiriam Molina ArcasJulian Downward Science advances Published 22 July 2022 Crick labs/ facilitiesJulian DownwardBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth Authors (7)Anna Perdrix Rosell Oscar Maiques Joshua Alexander James Martin Probir ChakravartyLuigi Ombrato Victoria Sanz-MorenoIlaria Malanchi Cancer Letters Published 28 September 2022 Crick labs/ facilitiesIlaria MalanchiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details GREM1 is required to maintain cellular heterogeneity in pancreatic cancer Authors (21) Linxiang Lan Theodore Evan Huafu Li Aasia Hussain E Josue Ruiz May Zaw Thin[...]Emma Nye Yulong He Changhua Zhang Anguraj SadanandamAxel Behrens Nature Published 7 July 2022 Crick labs/ facilitiesIlaria MalanchiGeorge KassiotisAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses Authors (22)Jacqui Marshall Joshua J Cull Hajed O Alharbi May Zaw Thin Susanna TE Cooper Christopher Barrington[...] Owen JL Rackham Daniel Meijles Tim Mohun Angela ClerkPeter Parker Biochemical Journal Published 1 July 2022 Crick labs/ facilitiesPeter ParkerTim MohunIn Vivo ImagingExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsFull details Pagination First page First Previous page Previous … Page 5 Page 6 Page 7 Page 8 Current page 9 Page 10 Page 11 Page 12 Page 13 … Next page Next Last page Last Share the page Share on 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The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX Authors (5)Alessia CaramelloChristophe Galichet Miriam Llorian SopenaRobin Lovell-BadgeKarine Rizzoti Developmental Neurobiology Published 1 October 2022 Crick labs/ facilitiesRobin Lovell-BadgeBioinformatics and BiostatisticsLight MicroscopyBiological Research FacilityAdvanced SequencingFull details
SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export Authors (7)Ross HallAnabel GuedanMelvyn YapGeorge Young Ruth HarveyJonathan StoyeKate Bishop PLOS Pathogens Published 25 August 2022 Crick labs/ facilitiesJonathan StoyeKate BishopWorldwide Influenza CentreBioinformatics and BiostatisticsAdvanced SequencingFull details
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening Authors (16) Marianna Ioannou Dennis Hoving Iker Valle AramburuMia Temkin Nathalia M De Vasconcelos Theodora Dorita Tsourouktsoglou[...]Markus Ralser Sascha David Klaus Stahl Christian BodeVenizelos Papayannopoulos Nature Communications Published 9 August 2022 Crick labs/ facilitiesMarkus RalserVenizelos PapayannopoulosBioinformatics and BiostatisticsAdvanced SequencingFull details
An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations Authors (26)Jesse BoumelhaSophie de Carne Emily K Law Pablo Romero-Clavijo Matthew A CoelhoKevin Ng[...]George KassiotisMiriam Molina ArcasCharles Swanton Reuben HarrisJulian Downward Cancer Research Published 1 October 2022 Crick labs/ facilitiesCharles SwantonGeorge KassiotisJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsScientific computingFlow CytometryCell ServicesBiological Research FacilityFull details
ADAR1 averts fatal type I interferon induction by ZBP1 Authors (17) Huipeng Jiao Laurens Wachsmuth Simone Wolf Juliane Lohmann Masahiro Nagata Göksu Gökberk Kaya[...] Marco Prinz Christoph SchellGeorge YoungGeorge Kassiotis Manolis Pasparakis Nature Published 28 July 2022 Crick labs/ facilitiesGeorge KassiotisBioinformatics and BiostatisticsFull details
Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers Authors (14)Edurne MugarzaFebe VanMaldegemJesse BoumelhaChristopher MooreSareena RanaMiriam Llorian Sopena[...] Pablo Romero-ClavijoKarishma ValandMegan ColeMiriam Molina ArcasJulian Downward Science advances Published 22 July 2022 Crick labs/ facilitiesJulian DownwardBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth Authors (7)Anna Perdrix Rosell Oscar Maiques Joshua Alexander James Martin Probir ChakravartyLuigi Ombrato Victoria Sanz-MorenoIlaria Malanchi Cancer Letters Published 28 September 2022 Crick labs/ facilitiesIlaria MalanchiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
GREM1 is required to maintain cellular heterogeneity in pancreatic cancer Authors (21) Linxiang Lan Theodore Evan Huafu Li Aasia Hussain E Josue Ruiz May Zaw Thin[...]Emma Nye Yulong He Changhua Zhang Anguraj SadanandamAxel Behrens Nature Published 7 July 2022 Crick labs/ facilitiesIlaria MalanchiGeorge KassiotisAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses Authors (22)Jacqui Marshall Joshua J Cull Hajed O Alharbi May Zaw Thin Susanna TE Cooper Christopher Barrington[...] Owen JL Rackham Daniel Meijles Tim Mohun Angela ClerkPeter Parker Biochemical Journal Published 1 July 2022 Crick labs/ facilitiesPeter ParkerTim MohunIn Vivo ImagingExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsFull details
