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Breadcrumb Bioinformatics and Biostatistics Bioinformatics and Biostatistics : Publications Lab contentLab contentIn this section Overview Publications Members Bioinformatic visualisation of protein binding along a human chromosome, courtesy of Federico Agostini and Nick Luscombe. Toggle to view hero caption Publications Displaying 91 - 100 of 442Last updated : 28 March 2024 03:39 UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1 Authors (9)Anna Herlihy Stefan Boeing Juston C WeemsJane WalkerBarbara Dirac-SvejstrupMichelle Lehner Ronald C Conaway Joan W ConawayJesper Svejstrup DNA Repair Published 1 July 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling Authors (24) Noémie Alphonse Joseph J Wanford Andrew A Voak Jack Gay Shayla Venkhaya Owen Burroughs[...] Martin W Berchtold Julien RC BergeronAndreas Wack Cammie F Lesser Charlotte Odendall Cell Published 23 June 2022 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsExperimental HistopathologyAdvanced SequencingFull details Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation Authors (7)Robert Blassberg Harshil Patel Thomas Watson Mina GoutiVicki MetzisJoaquina Delas VivesJames Briscoe Nature Cell Biology Published 1 May 2022 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Authors (19)Jessica Nelson May Zaw ThinTheo Evan Steven HowellMary WuBruna Almeida[...]Bram Snijders Andreas Prachalias Yoh Zen Debashis SarkerAxel Behrens Nature Communications Published 19 April 2022 Crick labs/ facilitiesPeter RatcliffeAxel BehrensProteomicsMetabolomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Cell-intrinsic aryl hydrocarbon receptor signalling is required for the resolution of injury-induced colonic stem cells Authors (15)Kathleen ShahMuralidhara Maradana M Joaquina Delàs Amina Metidji Frederike Graelmann Miriam Llorian[...]Gavin KellyChris Cheshire Deendyal Bhurta Sandip B BharateBrigitta Stockinger Nature Communications Published 5 April 2022 Crick labs/ facilitiesGitta StockingerNicholas LuscombeJames BriscoeBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro Authors (8)Fay CooperGeorge Gentsch Richard MitterCamille BouissouLyn Healy Ana Hernandez RodriguezJim Smith Andreia S Bernardo Stem Cell Reports Published 12 April 2022 Crick labs/ facilitiesJim SmithHuman Embryonic Stem CellBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma Authors (17) Annalisa D'AvolaNathalie LegraveMylene Tajan Probir Chakravarty Ryan L Shearer Hamish W King[...]James Macrae John G GribbenDinis CaladoKaren VousdenJohn Riches Journal of Clinical Investigation Published 2 May 2022 Crick labs/ facilitiesKaren VousdenDinis CaladoMetabolomicsBioinformatics and BiostatisticsFull details A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses Authors (7)Davide Coda Harshil PatelIlaria Gori Tessa E GaarenstroomOk-Ryul SongMichael HowellCaroline Hill Journal of Cell Science Published 15 April 2022 Crick labs/ facilitiesCaroline HillHigh Throughput ScreeningBioinformatics and BiostatisticsFlow CytometryCell ServicesAdvanced SequencingFull details Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization Authors (12)Emma NolanVicky BridgemanLuigi OmbratoAdam KaroutasNick Rabas Celine Angeli Natascha Sewnath[...]Felipe Rodrigues Stuart HorswellPeter Faull Rebecca CarterIlaria Malanchi Nature Cancer Published 1 February 2022 Crick labs/ facilitiesIlaria MalanchiProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance Authors (23) Patrizia Romani Nunzia Nirchio Mattia Arboit Vito Barbieri Anna Tosi Federica Michielin[...] Stephen L Archer Paolo De Coppi Antonio Rosato Graziano Martello Sirio Dupont Nature Cell Biology Published 1 February 2022 Crick labs/ facilitiesBioinformatics and BiostatisticsFull details Pagination First page First Previous page Previous … Page 6 Page 7 Page 8 Page 9 Current page 10 Page 11 Page 12 Page 13 Page 14 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1 Authors (9)Anna Herlihy Stefan Boeing Juston C WeemsJane WalkerBarbara Dirac-SvejstrupMichelle Lehner Ronald C Conaway Joan W ConawayJesper Svejstrup DNA Repair Published 1 July 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFull details
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling Authors (24) Noémie Alphonse Joseph J Wanford Andrew A Voak Jack Gay Shayla Venkhaya Owen Burroughs[...] Martin W Berchtold Julien RC BergeronAndreas Wack Cammie F Lesser Charlotte Odendall Cell Published 23 June 2022 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsExperimental HistopathologyAdvanced SequencingFull details
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation Authors (7)Robert Blassberg Harshil Patel Thomas Watson Mina GoutiVicki MetzisJoaquina Delas VivesJames Briscoe Nature Cell Biology Published 1 May 2022 Crick labs/ facilitiesJames BriscoeBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Authors (19)Jessica Nelson May Zaw ThinTheo Evan Steven HowellMary WuBruna Almeida[...]Bram Snijders Andreas Prachalias Yoh Zen Debashis SarkerAxel Behrens Nature Communications Published 19 April 2022 Crick labs/ facilitiesPeter RatcliffeAxel BehrensProteomicsMetabolomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details
Cell-intrinsic aryl hydrocarbon receptor signalling is required for the resolution of injury-induced colonic stem cells Authors (15)Kathleen ShahMuralidhara Maradana M Joaquina Delàs Amina Metidji Frederike Graelmann Miriam Llorian[...]Gavin KellyChris Cheshire Deendyal Bhurta Sandip B BharateBrigitta Stockinger Nature Communications Published 5 April 2022 Crick labs/ facilitiesGitta StockingerNicholas LuscombeJames BriscoeBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro Authors (8)Fay CooperGeorge Gentsch Richard MitterCamille BouissouLyn Healy Ana Hernandez RodriguezJim Smith Andreia S Bernardo Stem Cell Reports Published 12 April 2022 Crick labs/ facilitiesJim SmithHuman Embryonic Stem CellBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details
PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma Authors (17) Annalisa D'AvolaNathalie LegraveMylene Tajan Probir Chakravarty Ryan L Shearer Hamish W King[...]James Macrae John G GribbenDinis CaladoKaren VousdenJohn Riches Journal of Clinical Investigation Published 2 May 2022 Crick labs/ facilitiesKaren VousdenDinis CaladoMetabolomicsBioinformatics and BiostatisticsFull details
A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses Authors (7)Davide Coda Harshil PatelIlaria Gori Tessa E GaarenstroomOk-Ryul SongMichael HowellCaroline Hill Journal of Cell Science Published 15 April 2022 Crick labs/ facilitiesCaroline HillHigh Throughput ScreeningBioinformatics and BiostatisticsFlow CytometryCell ServicesAdvanced SequencingFull details
Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization Authors (12)Emma NolanVicky BridgemanLuigi OmbratoAdam KaroutasNick Rabas Celine Angeli Natascha Sewnath[...]Felipe Rodrigues Stuart HorswellPeter Faull Rebecca CarterIlaria Malanchi Nature Cancer Published 1 February 2022 Crick labs/ facilitiesIlaria MalanchiProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance Authors (23) Patrizia Romani Nunzia Nirchio Mattia Arboit Vito Barbieri Anna Tosi Federica Michielin[...] Stephen L Archer Paolo De Coppi Antonio Rosato Graziano Martello Sirio Dupont Nature Cell Biology Published 1 February 2022 Crick labs/ facilitiesBioinformatics and BiostatisticsFull details