Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Cell Services Cell Services : Publications Lab contentLab contentIn this section Overview Techniques Publications Members Colour-enhanced image of human colon cancer cells in culture. Image credit: Wellcome Collection. Toggle to view hero caption Publications Displaying 11 - 20 of 133Last updated : 25 April 2024 03:31 Human endogenous retrovirus onco-exaptation counters cancer cell senescence through calbindin Authors (14)Jan AttigJudith PapeLaura DoglioAnastasiya KazachenkaEleonora OttinaGeorge Young[...]Nikhil Faulkner William BollandVenizelos PapayannopoulosCharles SwantonGeorge Kassiotis Journal of Clinical Investigation Published 17 July 2023 Crick labs/ facilitiesCharles SwantonVenizelos PapayannopoulosGeorge KassiotisBioinformatics and BiostatisticsScientific computingLight MicroscopyIn Vivo ImagingHigh Throughput ScreeningFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details Generation of an MTM1-mutant iPSC line (CRICKi008-A) from an individual with X-linked myotubular myopathy (XLMTM) Authors (5)Liani Gasparini DevitoValentina Lionello Francesco MuntoniFrancesco Saverio TedescoLyn Healy Stem Cell Research Published 1 June 2023 Crick labs/ facilitiesFrancesco Saverio TedescoHuman Embryonic Stem CellCell ServicesAdvanced SequencingFull details Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma Authors (12) Takuya KatoRob Jenkins Stefanie Derzsi Melda TozluogluToni Rullan IriarteSteven Hooper[...] Holly JoyceXiao Fu Selvam ThavarajPaul BatesErik Sahai eLife Published 9 March 2023 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice Authors (11)Darryl HaywardLesley Vanes Stefanie Wissmann Sujana Sivapatham Harald HartwegerJoshua Biggs O'MayLeon De Boer Richard MitterRobert Koechl Jens V SteinVictor Tybulewicz Journal of Experimental Medicine Published 6 March 2023 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsMedia PreparationLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication Authors (4)Jingkun ZengStephanie HillsEiko OzonoJohn Diffley Cell Published 20 January 2023 Crick labs/ facilitiesJohn DiffleyLight MicroscopyFlow CytometryCell ServicesFull details Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restriction Authors (10)Simon ButterworthFrancesca TorelliEloise LockyerJeanette WagenerOk-Ryul SongMalgorzata BroncelMatt Russell Aline Cristina A Moreira-SouzaJoanna YoungMoritz Treeck PLOS Pathogens Published 7 December 2022 Crick labs/ facilitiesMoritz TreeckProteomicsHigh Throughput ScreeningElectron MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details Generation of FOUR iPSC lines (CRICKi004-A; CRICKi005-A; CRICKi006-A, CRICKi007-A) from spinal muscle atrophy patients with lower extremity dominant (SMALED) phenotype Authors (5)Liani Gasparini Devito Fay Cooper Ilenia D'AngeloJim SmithLyn Healy Stem Cell Research Published 1 December 2022 Crick labs/ facilitiesJim SmithHuman Embryonic Stem CellCell ServicesAdvanced SequencingFull details Cell-specific bioorthogonal tagging of glycoproteins Authors (31)Anna CioceBea CalleTatiana Rizou Sarah C LoweryVicky Bridgeman Keira E Mahoney[...] Stuart M Haslam Sabine L Flitsch Stacy A MalakerIlaria MalanchiBen Schumann Nature Communications Published 25 October 2022 Crick labs/ facilitiesJernej UleBen SchumannIlaria MalanchiLuiz Pedro CarvalhoStructural BiologyProteomicsBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress Authors (9)Michelle LehnerJane Walker Kotryna TemcinaiteAnna Herlihy Michael Taschner Adam C Berger Anita H Corbett A Barbara Dirac SvejstrupJesper Svejstrup Cell Reports Published 25 October 2022 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningFlow CytometryCell ServicesBioinformatics and BiostatisticsFull details Pagination First page First Previous page Previous Page 1 Current page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Human endogenous retrovirus onco-exaptation counters cancer cell senescence through calbindin Authors (14)Jan AttigJudith PapeLaura DoglioAnastasiya KazachenkaEleonora OttinaGeorge Young[...]Nikhil Faulkner William BollandVenizelos PapayannopoulosCharles SwantonGeorge Kassiotis Journal of Clinical Investigation Published 17 July 2023 Crick labs/ facilitiesCharles SwantonVenizelos PapayannopoulosGeorge KassiotisBioinformatics and BiostatisticsScientific computingLight MicroscopyIn Vivo ImagingHigh Throughput ScreeningFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details
Generation of an MTM1-mutant iPSC line (CRICKi008-A) from an individual with X-linked myotubular myopathy (XLMTM) Authors (5)Liani Gasparini DevitoValentina Lionello Francesco MuntoniFrancesco Saverio TedescoLyn Healy Stem Cell Research Published 1 June 2023 Crick labs/ facilitiesFrancesco Saverio TedescoHuman Embryonic Stem CellCell ServicesAdvanced SequencingFull details
Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma Authors (12) Takuya KatoRob Jenkins Stefanie Derzsi Melda TozluogluToni Rullan IriarteSteven Hooper[...] Holly JoyceXiao Fu Selvam ThavarajPaul BatesErik Sahai eLife Published 9 March 2023 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice Authors (11)Darryl HaywardLesley Vanes Stefanie Wissmann Sujana Sivapatham Harald HartwegerJoshua Biggs O'MayLeon De Boer Richard MitterRobert Koechl Jens V SteinVictor Tybulewicz Journal of Experimental Medicine Published 6 March 2023 Crick labs/ facilitiesVictor TybulewiczBioinformatics and BiostatisticsMedia PreparationLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication Authors (4)Jingkun ZengStephanie HillsEiko OzonoJohn Diffley Cell Published 20 January 2023 Crick labs/ facilitiesJohn DiffleyLight MicroscopyFlow CytometryCell ServicesFull details
Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restriction Authors (10)Simon ButterworthFrancesca TorelliEloise LockyerJeanette WagenerOk-Ryul SongMalgorzata BroncelMatt Russell Aline Cristina A Moreira-SouzaJoanna YoungMoritz Treeck PLOS Pathogens Published 7 December 2022 Crick labs/ facilitiesMoritz TreeckProteomicsHigh Throughput ScreeningElectron MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Generation of FOUR iPSC lines (CRICKi004-A; CRICKi005-A; CRICKi006-A, CRICKi007-A) from spinal muscle atrophy patients with lower extremity dominant (SMALED) phenotype Authors (5)Liani Gasparini Devito Fay Cooper Ilenia D'AngeloJim SmithLyn Healy Stem Cell Research Published 1 December 2022 Crick labs/ facilitiesJim SmithHuman Embryonic Stem CellCell ServicesAdvanced SequencingFull details
Cell-specific bioorthogonal tagging of glycoproteins Authors (31)Anna CioceBea CalleTatiana Rizou Sarah C LoweryVicky Bridgeman Keira E Mahoney[...] Stuart M Haslam Sabine L Flitsch Stacy A MalakerIlaria MalanchiBen Schumann Nature Communications Published 25 October 2022 Crick labs/ facilitiesJernej UleBen SchumannIlaria MalanchiLuiz Pedro CarvalhoStructural BiologyProteomicsBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress Authors (9)Michelle LehnerJane Walker Kotryna TemcinaiteAnna Herlihy Michael Taschner Adam C Berger Anita H Corbett A Barbara Dirac SvejstrupJesper Svejstrup Cell Reports Published 25 October 2022 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningFlow CytometryCell ServicesBioinformatics and BiostatisticsFull details
