Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Cell Services Cell Services : Publications Lab contentLab contentIn this section Overview Techniques Publications Members Colour-enhanced image of human colon cancer cells in culture. Image credit: Wellcome Collection. Toggle to view hero caption Publications Displaying 21 - 30 of 132Last updated : 19 April 2024 03:45 An important role for RPRD1B in the heat shock response Authors (6) Simona CugusiPrashanth Bajpe Richard Mitter Harshil PatelAengus StewartJesper Svejstrup Molecular and Cellular Biology Published 1 October 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations Authors (26)Jesse BoumelhaSophie de Carne Emily K Law Pablo Romero-Clavijo Matthew A CoelhoKevin Ng[...]George KassiotisMiriam Molina ArcasCharles Swanton Reuben HarrisJulian Downward Cancer Research Published 1 October 2022 Crick labs/ facilitiesCharles SwantonGeorge KassiotisJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsScientific computingFlow CytometryCell ServicesBiological Research FacilityFull details Global analysis of cytosine and adenine DNA modifications across the tree of life Authors (8) Sreejith Jayasree VarmaEnrica Calvani Nana-Maria GrüningChristoph Messner Nicholas Grayson Floriana Capuano Michael MüllederMarkus Ralser eLife Published 28 July 2022 Crick labs/ facilitiesMarkus RalserCell ServicesBiological Research FacilityFull details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers Authors (14) Edurne MugarzaFebe VanMaldegemJesse BoumelhaChristopher MooreSareena RanaMiriam Llorian Sopena[...] Pablo Romero-ClavijoKarishma ValandMegan ColeMiriam Molina ArcasJulian Downward Science advances Published 22 July 2022 Crick labs/ facilitiesJulian DownwardBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details The relative binding position of Nck and Grb2 adaptors impacts actin-based motility of Vaccinia virus Authors (2)Angika BasantMichael Way eLife Published 7 July 2022 Crick labs/ facilitiesMichael WayCell ServicesAdvanced SequencingFull details CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia Authors (14)William Grey Ana Rio-Machin Pedro CasadoEva GronroosSara Ali Juho J Miettinen[...]Charles Swanton Pedro R Cutillas John Gribben Jude FitzgibbonDominique Bonnet Science Translational Medicine Published 22 June 2022 Crick labs/ facilitiesCharles SwantonDominique BonnetFlow CytometryCell ServicesBiological Research FacilityFull details Structural analysis and development of Notum fragment screening hits Authors (21) Yuguang Zhao William Mahy Nicky J Willis Hannah L Woodward David Steadman Elliott D Bayle[...] Patricia C Salinas Paul WhitingJean-Paul Vincent Paul V Fish E Yvonne Jones ACS Chemical Neuroscience Published 6 July 2022 Crick labs/ facilitiesJean-Paul VincentStructural BiologyCell ServicesFull details Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit Authors (24) Nicky J Willis William Mahy James Sipthorp Yuguang Zhao Hannah L Woodward Benjamin N Atkinson[...] Patricia C SalinasJean-Paul Vincent E Yvonne Jones Paul Whiting Paul V Fish Journal of Medicinal Chemistry Published 26 May 2022 Crick labs/ facilitiesJean-Paul VincentStructural BiologyProteomicsTranslation teamCell ServicesFull details Real-time imaging of single γTuRC-mediated microtubule nucleation events in vitro by TIRF microscopy Authors (4)Tanja ConsolatiGil HenkinJohanna Roostalu Thomas Surrey Methods in Molecular Biology Published 28 April 2022 Crick labs/ facilitiesThomas SurreyCell ServicesFull details Pagination First page First Previous page Previous Page 1 Page 2 Current page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
An important role for RPRD1B in the heat shock response Authors (6) Simona CugusiPrashanth Bajpe Richard Mitter Harshil PatelAengus StewartJesper Svejstrup Molecular and Cellular Biology Published 1 October 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details
An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations Authors (26)Jesse BoumelhaSophie de Carne Emily K Law Pablo Romero-Clavijo Matthew A CoelhoKevin Ng[...]George KassiotisMiriam Molina ArcasCharles Swanton Reuben HarrisJulian Downward Cancer Research Published 1 October 2022 Crick labs/ facilitiesCharles SwantonGeorge KassiotisJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsScientific computingFlow CytometryCell ServicesBiological Research FacilityFull details
Global analysis of cytosine and adenine DNA modifications across the tree of life Authors (8) Sreejith Jayasree VarmaEnrica Calvani Nana-Maria GrüningChristoph Messner Nicholas Grayson Floriana Capuano Michael MüllederMarkus Ralser eLife Published 28 July 2022 Crick labs/ facilitiesMarkus RalserCell ServicesBiological Research FacilityFull details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers Authors (14) Edurne MugarzaFebe VanMaldegemJesse BoumelhaChristopher MooreSareena RanaMiriam Llorian Sopena[...] Pablo Romero-ClavijoKarishma ValandMegan ColeMiriam Molina ArcasJulian Downward Science advances Published 22 July 2022 Crick labs/ facilitiesJulian DownwardBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
The relative binding position of Nck and Grb2 adaptors impacts actin-based motility of Vaccinia virus Authors (2)Angika BasantMichael Way eLife Published 7 July 2022 Crick labs/ facilitiesMichael WayCell ServicesAdvanced SequencingFull details
CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia Authors (14)William Grey Ana Rio-Machin Pedro CasadoEva GronroosSara Ali Juho J Miettinen[...]Charles Swanton Pedro R Cutillas John Gribben Jude FitzgibbonDominique Bonnet Science Translational Medicine Published 22 June 2022 Crick labs/ facilitiesCharles SwantonDominique BonnetFlow CytometryCell ServicesBiological Research FacilityFull details
Structural analysis and development of Notum fragment screening hits Authors (21) Yuguang Zhao William Mahy Nicky J Willis Hannah L Woodward David Steadman Elliott D Bayle[...] Patricia C Salinas Paul WhitingJean-Paul Vincent Paul V Fish E Yvonne Jones ACS Chemical Neuroscience Published 6 July 2022 Crick labs/ facilitiesJean-Paul VincentStructural BiologyCell ServicesFull details
Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit Authors (24) Nicky J Willis William Mahy James Sipthorp Yuguang Zhao Hannah L Woodward Benjamin N Atkinson[...] Patricia C SalinasJean-Paul Vincent E Yvonne Jones Paul Whiting Paul V Fish Journal of Medicinal Chemistry Published 26 May 2022 Crick labs/ facilitiesJean-Paul VincentStructural BiologyProteomicsTranslation teamCell ServicesFull details
Real-time imaging of single γTuRC-mediated microtubule nucleation events in vitro by TIRF microscopy Authors (4)Tanja ConsolatiGil HenkinJohanna Roostalu Thomas Surrey Methods in Molecular Biology Published 28 April 2022 Crick labs/ facilitiesThomas SurreyCell ServicesFull details
