Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Cell Services Cell Services : Publications Lab contentLab contentIn this section Overview Techniques Publications Members Colour-enhanced image of human colon cancer cells in culture. Image credit: Wellcome Collection. Toggle to view hero caption Publications Displaying 81 - 90 of 133Last updated : 23 April 2024 03:27 Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii Authors (10)Alexander HuntMatt RussellJeanette Wagener Robyn Kent Romain CarmeilleChris PeddieLucy Collinson Aoife Heaslip Gary E WardMoritz Treeck eLife Published 2 October 2019 Crick labs/ facilitiesMoritz TreeckElectron MicroscopyLight MicroscopyHigh Throughput ScreeningFlow CytometryCell ServicesFull details Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer Authors (12)Miriam Molina ArcasChristopher MooreSareena RanaFebe VanMaldegemEdurne Mugarza Pablo Romero-Clavijo[...] Stuart Horswell Lian-Sheng Li Matthew R JanesDavid HancockJulian Downward Science Translational Medicine Published 18 September 2019 Crick labs/ facilitiesJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsCell ServicesBiological Research FacilityAdvanced SequencingFull details Metastatic-niche labelling reveals parenchymal cells with stem features Authors (18)Luigi OmbratoEmma Nolan Ivana Kurelac Antranik MavousianVicky Bridgeman Ivonne Heinze[...] Valerie SpeirsLucy Collinson Alessandro Ori Joo-Hyeon LeeIlaria Malanchi Nature Published 28 August 2019 Crick labs/ facilitiesIlaria MalanchiElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma Authors (14) Thanos P MourikisLorena Benedetti Elizabeth FoxallDamjan TemelkovskiJoel Nulsen Juliane Perner[...] Christopher Yau Rebecca C FitzgeraldPaola Scaffidi Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) ConsortiumFrancesca Ciccarelli Nature Communications Published 15 July 2019 Crick labs/ facilitiesPaola ScaffidiFrancesca CiccarelliHigh Throughput ScreeningFlow CytometryCell ServicesAdvanced SequencingFull details Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines Authors (23) Jamie L Almeida Aleksandra Dakic Karin Kindig Maikan Kone Deborah LD Letham Scott Langdon[...] Manuela Natoli Beth Bauer Susanne M Gollin Dale W Lewis Yvonne Reid PLOS ONE Published 20 June 2019 Crick labs/ facilitiesCell ServicesFull details TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation Authors (3)Daniel Miller Bernhard SchmiererCaroline Hill Journal of Cell Science Published 15 July 2019 Crick labs/ facilitiesCaroline HillCell ServicesFull details A ubiquitin-binding domain that binds a structural fold distinct from that of ubiquitin Authors (8) Michael Lim Joseph A Newman Hannah L WilliamsLaura Masino Hazel Aitkenhead Angeline E Gravard Opher GileadiJesper Svejstrup Structure Published 6 August 2019 Crick labs/ facilitiesJesper SvejstrupStructural BiologyProteomicsCell ServicesFull details SCAF4 and SCAF8, mRNA anti-terminator proteins Authors (8)Lea Gregersen Richard Mitter Alejandro P Ugalde Takayuki Nojima Nicholas J Proudfoot Reuven AgamiAengus StewartJesper Svejstrup Cell Published 13 June 2019 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details Role of forward and reverse signaling in Eph receptor and ephrin mediated cell segregation Authors (4) Zhonglin WuTimothy AshlinQiling Xu David G Wilkinson Experimental Cell Research Published 1 August 2019 Crick labs/ facilitiesDavid WilkinsonLight MicroscopyCell ServicesFull details Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen Authors (14) Benjamin N Atkinson David Steadman Yuguang Zhao James Sipthorp Luca Vecchia Reinis R Ruza[...] Amy MonaghanSvend Kjaer Magda Bictash E Yvonne Jones Paul V Fish MedChemComm Published 1 August 2019 Crick labs/ facilitiesStructural BiologyCell ServicesFull details Pagination First page First Previous page Previous … Page 5 Page 6 Page 7 Page 8 Current page 9 Page 10 Page 11 Page 12 Page 13 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii Authors (10)Alexander HuntMatt RussellJeanette Wagener Robyn Kent Romain CarmeilleChris PeddieLucy Collinson Aoife Heaslip Gary E WardMoritz Treeck eLife Published 2 October 2019 Crick labs/ facilitiesMoritz TreeckElectron MicroscopyLight MicroscopyHigh Throughput ScreeningFlow CytometryCell ServicesFull details
Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer Authors (12)Miriam Molina ArcasChristopher MooreSareena RanaFebe VanMaldegemEdurne Mugarza Pablo Romero-Clavijo[...] Stuart Horswell Lian-Sheng Li Matthew R JanesDavid HancockJulian Downward Science Translational Medicine Published 18 September 2019 Crick labs/ facilitiesJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsCell ServicesBiological Research FacilityAdvanced SequencingFull details
Metastatic-niche labelling reveals parenchymal cells with stem features Authors (18)Luigi OmbratoEmma Nolan Ivana Kurelac Antranik MavousianVicky Bridgeman Ivonne Heinze[...] Valerie SpeirsLucy Collinson Alessandro Ori Joo-Hyeon LeeIlaria Malanchi Nature Published 28 August 2019 Crick labs/ facilitiesIlaria MalanchiElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma Authors (14) Thanos P MourikisLorena Benedetti Elizabeth FoxallDamjan TemelkovskiJoel Nulsen Juliane Perner[...] Christopher Yau Rebecca C FitzgeraldPaola Scaffidi Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) ConsortiumFrancesca Ciccarelli Nature Communications Published 15 July 2019 Crick labs/ facilitiesPaola ScaffidiFrancesca CiccarelliHigh Throughput ScreeningFlow CytometryCell ServicesAdvanced SequencingFull details
Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines Authors (23) Jamie L Almeida Aleksandra Dakic Karin Kindig Maikan Kone Deborah LD Letham Scott Langdon[...] Manuela Natoli Beth Bauer Susanne M Gollin Dale W Lewis Yvonne Reid PLOS ONE Published 20 June 2019 Crick labs/ facilitiesCell ServicesFull details
TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation Authors (3)Daniel Miller Bernhard SchmiererCaroline Hill Journal of Cell Science Published 15 July 2019 Crick labs/ facilitiesCaroline HillCell ServicesFull details
A ubiquitin-binding domain that binds a structural fold distinct from that of ubiquitin Authors (8) Michael Lim Joseph A Newman Hannah L WilliamsLaura Masino Hazel Aitkenhead Angeline E Gravard Opher GileadiJesper Svejstrup Structure Published 6 August 2019 Crick labs/ facilitiesJesper SvejstrupStructural BiologyProteomicsCell ServicesFull details
SCAF4 and SCAF8, mRNA anti-terminator proteins Authors (8)Lea Gregersen Richard Mitter Alejandro P Ugalde Takayuki Nojima Nicholas J Proudfoot Reuven AgamiAengus StewartJesper Svejstrup Cell Published 13 June 2019 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details
Role of forward and reverse signaling in Eph receptor and ephrin mediated cell segregation Authors (4) Zhonglin WuTimothy AshlinQiling Xu David G Wilkinson Experimental Cell Research Published 1 August 2019 Crick labs/ facilitiesDavid WilkinsonLight MicroscopyCell ServicesFull details
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen Authors (14) Benjamin N Atkinson David Steadman Yuguang Zhao James Sipthorp Luca Vecchia Reinis R Ruza[...] Amy MonaghanSvend Kjaer Magda Bictash E Yvonne Jones Paul V Fish MedChemComm Published 1 August 2019 Crick labs/ facilitiesStructural BiologyCell ServicesFull details
