Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Electron Microscopy Electron Microscopy : Publications Lab contentLab contentIn this section Overview Technologies Microscopy prototyping Publications Members News A false-coloured SEM image of cultured lung cancer cells Toggle to view hero caption PublicationsResearch topicsImaging (132)Model Organisms (76)Cell Biology (73)Biochemistry & Proteomics (61)Chemical Biology & High Throughput (48)Infectious Disease (48)Computational & Systems Biology (47)Structural Biology & Biophysics (40)Cell Cycle & Chromosomes (37)Immunology (37)Genome Integrity & Repair (35)Genetics & Genomics (33)Tumour Biology (28)Signalling & Oncogenes (27)Human Biology & Physiology (26)Developmental Biology (23)Stem Cells (18)Neurosciences (15)Gene Expression (11)Metabolism (11)Microfabrication & Bioengineering (11)Synthetic Biology (4) Facet Research topicsJournal (-)Trends in Immunology (6) Facet Journal Publications Displaying 1 - 10 of 196Last updated : 16 April 2024 03:22 Accelerating data sharing and reuse in volume electron microscopy Authors (6) Kirk James Czymmek Ilya Belevich Johanna Bischof Aastha MathurLucy Collinson Eija Jokitalo Nature Cell Biology Published 12 April 2024 Crick labs/ facilitiesElectron MicroscopyFull details Automated segmentation of cell organelles in volume electron microscopy using deep learning Authors (13) Nebojša Nešić Xavier Heiligenstein Lydia Zopf Valentin Blüml Katharina S Keuenhof Michael Wagner[...] Zhiyang Li Georgios TsaramirsisChris Peddie Miloš Stojmenović Andreas Walter Microscopy Research and Technique Published 19 March 2024 Crick labs/ facilitiesElectron MicroscopyFull details Integrating cellular electron microscopy with multimodal data to explore biology across space and time Authors (6) Caitlyn L McCafferty Sven Klumpe Rommie E Amaro Wanda KukulskiLucy Collinson Benjamin D Engel Cell Published 1 February 2024 Crick labs/ facilitiesElectron MicroscopyFull details Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer Authors (40) Peter Kreuzaler Paolo IngleseAvinash GhanateErsa Gjelaj Vincen WuYulia Panina[...] George Poulogiannis Greg McMahon Zoltan Takats Josephine BunchMariia Yuneva Nature Metabolism Published 1 November 2023 Crick labs/ facilitiesMariia YunevaLuiz Pedro CarvalhoMetabolomicsExperimental HistopathologyElectron MicroscopyBiological Research FacilityFull details Interview with FocalPlane Scientific Advisory Board member Lucy Collinson Authors (2) Helen ZennerLucy Collinson Journal of Cell Science Published 15 October 2023 Crick labs/ facilitiesElectron MicroscopyFull details Current progress and challenges in large-scale 3D mitochondria instance segmentation Authors (27) Daniel Franco-Barranco Zudi Lin Won-Dong Jang Xueying Wang Qijia Shen Wenjie Yin[...] Dorsa Ziaei Stephan Huschauer Ignacio Arganda-Carreras Hanspeter Pfister Donglai Wei IEEE Transactions on Medical Imaging Published 1 December 2023 Crick labs/ facilitiesElectron MicroscopyScientific computingFull details Bridging Imaging Users to Imaging Analysis - A community survey Authors (8) Suganya Sivagurunathan Stefania Marcotti Carl J NelsonMartin JonesDavid Barry Thomas JA Slater Kevin W Eliceiri Beth A Cimini Journal of Microscopy Published 20 September 2023 Crick labs/ facilitiesLight MicroscopyElectron MicroscopyFull details Emergent mechanical control of vascular morphogenesis Authors (29) Jordan Whisler Somayeh ShahrezaKarin Schlegelmilch Nil Ege Yousef Javanmardi Andrea Malandrino[...] Fernando Calvo Christiana RuhrbergErik Sahai Roger Kamm Emad Moeendarbary Science advances Published 11 August 2023 Crick labs/ facilitiesErik SahaiExperimental HistopathologyElectron MicroscopyFull details Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation Authors (13) Paul-Christian BurdaAbhinay Ramaprasad Sabrina Bielfeld Emma Pietsch Anna Woitalla Christoph Söhnchen[...]Aaron SaitLucy Collinson Dominik SchwudkeMichael Blackman Tim-Wolf Gilberger mBio Published 31 August 2023 Crick labs/ facilitiesMike BlackmanElectron MicroscopyFull details The role of Plasmodium V-ATPase in vacuolar physiology and antimalarial drug uptake Authors (8) Arne Alder Cecilia P SanchezMatt RussellLucy Collinson Michael LanzerMichael Blackman Tim-Wolf Gilberger Joachim M Matz Proceedings of the National Academy of Sciences of USA Published 25 July 2023 Crick labs/ facilitiesMike BlackmanElectron MicroscopyFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Accelerating data sharing and reuse in volume electron microscopy Authors (6) Kirk James Czymmek Ilya Belevich Johanna Bischof Aastha MathurLucy Collinson Eija Jokitalo Nature Cell Biology Published 12 April 2024 Crick labs/ facilitiesElectron MicroscopyFull details
Automated segmentation of cell organelles in volume electron microscopy using deep learning Authors (13) Nebojša Nešić Xavier Heiligenstein Lydia Zopf Valentin Blüml Katharina S Keuenhof Michael Wagner[...] Zhiyang Li Georgios TsaramirsisChris Peddie Miloš Stojmenović Andreas Walter Microscopy Research and Technique Published 19 March 2024 Crick labs/ facilitiesElectron MicroscopyFull details
Integrating cellular electron microscopy with multimodal data to explore biology across space and time Authors (6) Caitlyn L McCafferty Sven Klumpe Rommie E Amaro Wanda KukulskiLucy Collinson Benjamin D Engel Cell Published 1 February 2024 Crick labs/ facilitiesElectron MicroscopyFull details
Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer Authors (40) Peter Kreuzaler Paolo IngleseAvinash GhanateErsa Gjelaj Vincen WuYulia Panina[...] George Poulogiannis Greg McMahon Zoltan Takats Josephine BunchMariia Yuneva Nature Metabolism Published 1 November 2023 Crick labs/ facilitiesMariia YunevaLuiz Pedro CarvalhoMetabolomicsExperimental HistopathologyElectron MicroscopyBiological Research FacilityFull details
Interview with FocalPlane Scientific Advisory Board member Lucy Collinson Authors (2) Helen ZennerLucy Collinson Journal of Cell Science Published 15 October 2023 Crick labs/ facilitiesElectron MicroscopyFull details
Current progress and challenges in large-scale 3D mitochondria instance segmentation Authors (27) Daniel Franco-Barranco Zudi Lin Won-Dong Jang Xueying Wang Qijia Shen Wenjie Yin[...] Dorsa Ziaei Stephan Huschauer Ignacio Arganda-Carreras Hanspeter Pfister Donglai Wei IEEE Transactions on Medical Imaging Published 1 December 2023 Crick labs/ facilitiesElectron MicroscopyScientific computingFull details
Bridging Imaging Users to Imaging Analysis - A community survey Authors (8) Suganya Sivagurunathan Stefania Marcotti Carl J NelsonMartin JonesDavid Barry Thomas JA Slater Kevin W Eliceiri Beth A Cimini Journal of Microscopy Published 20 September 2023 Crick labs/ facilitiesLight MicroscopyElectron MicroscopyFull details
Emergent mechanical control of vascular morphogenesis Authors (29) Jordan Whisler Somayeh ShahrezaKarin Schlegelmilch Nil Ege Yousef Javanmardi Andrea Malandrino[...] Fernando Calvo Christiana RuhrbergErik Sahai Roger Kamm Emad Moeendarbary Science advances Published 11 August 2023 Crick labs/ facilitiesErik SahaiExperimental HistopathologyElectron MicroscopyFull details
Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation Authors (13) Paul-Christian BurdaAbhinay Ramaprasad Sabrina Bielfeld Emma Pietsch Anna Woitalla Christoph Söhnchen[...]Aaron SaitLucy Collinson Dominik SchwudkeMichael Blackman Tim-Wolf Gilberger mBio Published 31 August 2023 Crick labs/ facilitiesMike BlackmanElectron MicroscopyFull details
The role of Plasmodium V-ATPase in vacuolar physiology and antimalarial drug uptake Authors (8) Arne Alder Cecilia P SanchezMatt RussellLucy Collinson Michael LanzerMichael Blackman Tim-Wolf Gilberger Joachim M Matz Proceedings of the National Academy of Sciences of USA Published 25 July 2023 Crick labs/ facilitiesMike BlackmanElectron MicroscopyFull details
