Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Experimental Histopathology Experimental Histopathology : Publications Lab contentLab contentIn this section Overview Publications Members Publications Displaying 41 - 50 of 233Last updated : 29 March 2024 03:54 USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Authors (19)Jessica Nelson May Zaw ThinTheo Evan Steven HowellMary WuBruna Almeida[...]Bram Snijders Andreas Prachalias Yoh Zen Debashis SarkerAxel Behrens Nature Communications Published 19 April 2022 Crick labs/ facilitiesPeter RatcliffeAxel BehrensProteomicsMetabolomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Cell-intrinsic aryl hydrocarbon receptor signalling is required for the resolution of injury-induced colonic stem cells Authors (15)Kathleen ShahMuralidhara Maradana M Joaquina Delàs Amina Metidji Frederike Graelmann Miriam Llorian[...]Gavin KellyChris Cheshire Deendyal Bhurta Sandip B BharateBrigitta Stockinger Nature Communications Published 5 April 2022 Crick labs/ facilitiesGitta StockingerNicholas LuscombeJames BriscoeBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways Authors (10)Spyridoula Nikou Chunsheng Zhou James S Griffiths Natalia K Kotowicz Bianca M ColemanMary Green David L Moyes Sarah L Gaffen Julian R Naglik Peter J Parker Science Signaling Published 5 April 2022 Crick labs/ facilitiesPeter ParkerExperimental HistopathologyCell ServicesFull details Genome-protective topoisomerase 2a-dependent G2arrest requires p53 in hTERT-positive cancer cells Authors (12)Nicola LockwoodSilvia Martini Ainara Lopez-Pardo Katharina Deiss Hendrika A Segeren Robert K Semple[...]Dimitra RepanaMathias Cobbaut Tanya SolimanFrancesca CiccarelliPeter Parker Cancer Research Published 1 March 2022 Crick labs/ facilitiesPeter ParkerFrancesca CiccarelliLight MicroscopyHigh Throughput ScreeningFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details The aryl hydrocarbon receptor contributes to tissue adaptation of intestinal eosinophils in mice Authors (6)Nicola Diny Barbora SchonfeldovaMichael Shapiro Matthew L WinderSunita Varsani-BrownBrigitta Stockinger Journal of Experimental Medicine Published 4 April 2022 Crick labs/ facilitiesGitta StockingerGenetic Modification ServiceBiological Research FacilityFlow CytometryExperimental HistopathologyElectron MicroscopyAdvanced SequencingFull details Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization Authors (12)Emma NolanVicky BridgemanLuigi OmbratoAdam KaroutasNick Rabas Celine Angeli Natascha Sewnath[...]Felipe Rodrigues Stuart HorswellPeter Faull Rebecca CarterIlaria Malanchi Nature Cancer Published 1 February 2022 Crick labs/ facilitiesIlaria MalanchiProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Normality sensing licenses local T cells for innate-like tissue surveillance Authors (7)Duncan McKenzie Rosie Hart Nourdine Bah Dmitry S UshakovMiguel Munoz-Ruiz Regina FeederleAdrian Hayday Nature Immunology Published 1 March 2022 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion Authors (27) Elizabeth R Murray Shinelle Menezes Jack C Henry Josie L Williams Lorena Alba-Castellón Priththivika Baskaran[...] Nuria Gavara Oliver Pearce Pedro Cutillas John F Marshall Angus JM Cameron Cell Reports Published 25 January 2022 Crick labs/ facilitiesPeter ParkerGenetic Modification ServiceBiological Research FacilityExperimental HistopathologyFull details Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Authors (35)Xiao Fu Yue Zhao Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Erik SahaiKevin LitchfieldSamra Turajlic TRACERx Renal ConsortiumPaul Bates Nature Ecology and Evolution Published 1 January 2022 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes Authors (8)Charlotte DouglasValdone MaciulyteJasmin ZohrenDaniel SnellShantha MahadevaiahAndrew Ojarikre Peter JI EllisJames Turner Nature Communications Published 3 December 2021 Crick labs/ facilitiesJames TurnerLight MicroscopyIn Vivo ImagingGenetic Modification ServiceFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Pagination First page First Previous page Previous Page 1 Page 2 Page 3 Page 4 Current page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Authors (19)Jessica Nelson May Zaw ThinTheo Evan Steven HowellMary WuBruna Almeida[...]Bram Snijders Andreas Prachalias Yoh Zen Debashis SarkerAxel Behrens Nature Communications Published 19 April 2022 Crick labs/ facilitiesPeter RatcliffeAxel BehrensProteomicsMetabolomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details
Cell-intrinsic aryl hydrocarbon receptor signalling is required for the resolution of injury-induced colonic stem cells Authors (15)Kathleen ShahMuralidhara Maradana M Joaquina Delàs Amina Metidji Frederike Graelmann Miriam Llorian[...]Gavin KellyChris Cheshire Deendyal Bhurta Sandip B BharateBrigitta Stockinger Nature Communications Published 5 April 2022 Crick labs/ facilitiesGitta StockingerNicholas LuscombeJames BriscoeBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways Authors (10)Spyridoula Nikou Chunsheng Zhou James S Griffiths Natalia K Kotowicz Bianca M ColemanMary Green David L Moyes Sarah L Gaffen Julian R Naglik Peter J Parker Science Signaling Published 5 April 2022 Crick labs/ facilitiesPeter ParkerExperimental HistopathologyCell ServicesFull details
Genome-protective topoisomerase 2a-dependent G2arrest requires p53 in hTERT-positive cancer cells Authors (12)Nicola LockwoodSilvia Martini Ainara Lopez-Pardo Katharina Deiss Hendrika A Segeren Robert K Semple[...]Dimitra RepanaMathias Cobbaut Tanya SolimanFrancesca CiccarelliPeter Parker Cancer Research Published 1 March 2022 Crick labs/ facilitiesPeter ParkerFrancesca CiccarelliLight MicroscopyHigh Throughput ScreeningFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
The aryl hydrocarbon receptor contributes to tissue adaptation of intestinal eosinophils in mice Authors (6)Nicola Diny Barbora SchonfeldovaMichael Shapiro Matthew L WinderSunita Varsani-BrownBrigitta Stockinger Journal of Experimental Medicine Published 4 April 2022 Crick labs/ facilitiesGitta StockingerGenetic Modification ServiceBiological Research FacilityFlow CytometryExperimental HistopathologyElectron MicroscopyAdvanced SequencingFull details
Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization Authors (12)Emma NolanVicky BridgemanLuigi OmbratoAdam KaroutasNick Rabas Celine Angeli Natascha Sewnath[...]Felipe Rodrigues Stuart HorswellPeter Faull Rebecca CarterIlaria Malanchi Nature Cancer Published 1 February 2022 Crick labs/ facilitiesIlaria MalanchiProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Normality sensing licenses local T cells for innate-like tissue surveillance Authors (7)Duncan McKenzie Rosie Hart Nourdine Bah Dmitry S UshakovMiguel Munoz-Ruiz Regina FeederleAdrian Hayday Nature Immunology Published 1 March 2022 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion Authors (27) Elizabeth R Murray Shinelle Menezes Jack C Henry Josie L Williams Lorena Alba-Castellón Priththivika Baskaran[...] Nuria Gavara Oliver Pearce Pedro Cutillas John F Marshall Angus JM Cameron Cell Reports Published 25 January 2022 Crick labs/ facilitiesPeter ParkerGenetic Modification ServiceBiological Research FacilityExperimental HistopathologyFull details
Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Authors (35)Xiao Fu Yue Zhao Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Erik SahaiKevin LitchfieldSamra Turajlic TRACERx Renal ConsortiumPaul Bates Nature Ecology and Evolution Published 1 January 2022 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details
CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes Authors (8)Charlotte DouglasValdone MaciulyteJasmin ZohrenDaniel SnellShantha MahadevaiahAndrew Ojarikre Peter JI EllisJames Turner Nature Communications Published 3 December 2021 Crick labs/ facilitiesJames TurnerLight MicroscopyIn Vivo ImagingGenetic Modification ServiceFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details