Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Fermentation Fermentation lab : Publications Lab contentLab contentIn this section Overview Publications Publications Displaying 1 - 10 of 35Last updated : 24 April 2024 03:31 Establishment of dsDNA-dsDNA interactions by the condensin complex Authors (8)Tony TangGeorge Pobegalov Hideki Tanizawa Zhuo A Chen Juri RappsilberMaxim Molodtsov Ken-ichi NomaFrank Uhlmann Molecular Cell Published 1 November 2023 Crick labs/ facilitiesFrank UhlmannMaxim MolodtsovFermentationBioinformatics and BiostatisticsFull details DNA-directed termination of RNA polymerase II transcription Authors (8) Zhong Han George A Moore Richard Mitter David Lopez MartinezLi Wan A Barbara Dirac Svejstrup David S RuedaJesper Svejstrup Molecular Cell Published 21 September 2023 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details Replisome-cohesin interactions provided by the Tof1-Csm3 and Mrc1 cohesion establishment factors Authors (6)Sudikchya ShresthaMasashi Minamino Zhuo A ChenCeline Bouchoux Juri RappsilberFrank Uhlmann Chromosoma Published 1 June 2023 Crick labs/ facilitiesFrank UhlmannFermentationBioinformatics and BiostatisticsFull details A replication fork determinant for the establishment of sister chromatid cohesion Authors (5)Masashi MinaminoCeline BouchouxBerta CanalJohn DiffleyFrank Uhlmann Cell Published 16 February 2023 Crick labs/ facilitiesFrank UhlmannJohn DiffleyStructural BiologyFermentationFull details Functional crosstalk between the cohesin loader and chromatin remodelers Authors (6)Sofia Munoz-FelixAndrew JonesCeline BouchouxTegan Gilmore Harshil PatelFrank Uhlmann Nature Communications Published 13 December 2022 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyHigh Throughput ScreeningFermentationFull details N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast Authors (18) Radhika A VarierTheodora SideriCharlotte CapitanchikZornitsa ManovaEnrica CalvaniAlice Rossi[...] Michiel VermeulenMarkus RalserJernej UleNicholas LuscombeFolkert Van Werven eLife Published 24 November 2022 Crick labs/ facilitiesFolkert van WervenJernej UleMarkus RalserNicholas LuscombeProteomicsMetabolomicsBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details RSC and GRFs confer promoter directionality by restricting divergent noncoding transcription Authors (6)Chun Kit WuClaudia Vivori Harshil PatelTheodora SideriFabien MorettoFolkert Van Werven Life Science Alliance Published 1 December 2022 Crick labs/ facilitiesFolkert van WervenBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details Mechanism of replication origin melting nucleated by CMG helicase assembly Authors (8)Jacob LewisMarta Gross Joana SousaSarah HenrikusJulia GreiweAndrea NansJohn DiffleyAlessandro Costa Nature Published 30 June 2022 Crick labs/ facilitiesJohn DiffleyAlessandro CostaStructural BiologyFermentationFull details Generation of double Holliday junction DNAs and their dissolution/resolution within a chromatin context Authors (2)Han Ngoc HoStephen West Proceedings of the National Academy of Sciences of USA Published 3 May 2022 Crick labs/ facilitiesStephen WestFermentationFull details Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation Authors (8)Anne Schreiber Ben C CollinsColin DavisRadoslav Enchev Angie SedraRocco D'Antuono Ruedi Aebersold Matthias Peter Molecular Cell Published 16 December 2021 Crick labs/ facilitiesAnne SchreiberRadoslav EnchevLight MicroscopyFermentationFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Establishment of dsDNA-dsDNA interactions by the condensin complex Authors (8)Tony TangGeorge Pobegalov Hideki Tanizawa Zhuo A Chen Juri RappsilberMaxim Molodtsov Ken-ichi NomaFrank Uhlmann Molecular Cell Published 1 November 2023 Crick labs/ facilitiesFrank UhlmannMaxim MolodtsovFermentationBioinformatics and BiostatisticsFull details
DNA-directed termination of RNA polymerase II transcription Authors (8) Zhong Han George A Moore Richard Mitter David Lopez MartinezLi Wan A Barbara Dirac Svejstrup David S RuedaJesper Svejstrup Molecular Cell Published 21 September 2023 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details
Replisome-cohesin interactions provided by the Tof1-Csm3 and Mrc1 cohesion establishment factors Authors (6)Sudikchya ShresthaMasashi Minamino Zhuo A ChenCeline Bouchoux Juri RappsilberFrank Uhlmann Chromosoma Published 1 June 2023 Crick labs/ facilitiesFrank UhlmannFermentationBioinformatics and BiostatisticsFull details
A replication fork determinant for the establishment of sister chromatid cohesion Authors (5)Masashi MinaminoCeline BouchouxBerta CanalJohn DiffleyFrank Uhlmann Cell Published 16 February 2023 Crick labs/ facilitiesFrank UhlmannJohn DiffleyStructural BiologyFermentationFull details
Functional crosstalk between the cohesin loader and chromatin remodelers Authors (6)Sofia Munoz-FelixAndrew JonesCeline BouchouxTegan Gilmore Harshil PatelFrank Uhlmann Nature Communications Published 13 December 2022 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyHigh Throughput ScreeningFermentationFull details
N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast Authors (18) Radhika A VarierTheodora SideriCharlotte CapitanchikZornitsa ManovaEnrica CalvaniAlice Rossi[...] Michiel VermeulenMarkus RalserJernej UleNicholas LuscombeFolkert Van Werven eLife Published 24 November 2022 Crick labs/ facilitiesFolkert van WervenJernej UleMarkus RalserNicholas LuscombeProteomicsMetabolomicsBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details
RSC and GRFs confer promoter directionality by restricting divergent noncoding transcription Authors (6)Chun Kit WuClaudia Vivori Harshil PatelTheodora SideriFabien MorettoFolkert Van Werven Life Science Alliance Published 1 December 2022 Crick labs/ facilitiesFolkert van WervenBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details
Mechanism of replication origin melting nucleated by CMG helicase assembly Authors (8)Jacob LewisMarta Gross Joana SousaSarah HenrikusJulia GreiweAndrea NansJohn DiffleyAlessandro Costa Nature Published 30 June 2022 Crick labs/ facilitiesJohn DiffleyAlessandro CostaStructural BiologyFermentationFull details
Generation of double Holliday junction DNAs and their dissolution/resolution within a chromatin context Authors (2)Han Ngoc HoStephen West Proceedings of the National Academy of Sciences of USA Published 3 May 2022 Crick labs/ facilitiesStephen WestFermentationFull details
Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation Authors (8)Anne Schreiber Ben C CollinsColin DavisRadoslav Enchev Angie SedraRocco D'Antuono Ruedi Aebersold Matthias Peter Molecular Cell Published 16 December 2021 Crick labs/ facilitiesAnne SchreiberRadoslav EnchevLight MicroscopyFermentationFull details
