Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb High Throughput Screening High Throughput Screening : Publications Lab contentLab contentIn this section Overview What we do Publications Members A plate handling robot (Access Robot; Labcyte) collecting a 384-well PCR plate from an automated centrifuge (background) to deliver it to an acoustic liquid handling device (the Echo550; Labcyte) Toggle to view hero caption Publications Displaying 1 - 10 of 140Last updated : 19 April 2024 02:06 Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia Authors (11)Fiona Grimm Agustín AsuajeAakriti JainMariana Silva Dos Santos Jens KleinjungPatricia Figueiredo Nunes Stefanie GehrigLouise Fets Salihanur DariciJames MacraeDimitrios Anastasiou The EMBO Journal Published 16 April 2024 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsBioinformatics and BiostatisticsLight MicroscopyHigh Throughput ScreeningAdvanced SequencingFull details Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 23 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20)Eva Lana-ElolaRifdat Aoidi Miriam LlorianDorota GibbinsCallan BuechsenschuetzClaudio Bussi[...] Laurent MeijerBram SnijdersMaximiliano Gutierrez Elizabeth MC FisherVictor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilitiesVictor TybulewiczMaximiliano GutierrezProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes Authors (18) Benjamin B Johnson Marie-Victoire CossonLorenza Iolanda Tsansizi Terri L HolmesTegan Gilmore Katherine Hampton[...] John Whitelock Linda Troeberg Stuart A Rushworth Andreia S Bernardo James GW Smith Cell Reports Published 23 January 2024 Crick labs/ facilitiesJim SmithHigh Throughput ScreeningBioinformatics and BiostatisticsStructural BiologyMaking LabAdvanced SequencingFull details The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes Authors (16) Federica RaguseoYiran Wang Jessica LiMarija Petric Howe Rubika Balendra Anouk Huyghebaert[...] Francesco A Aprile Yuval ElaniRickie Patani Lorenzo Di MicheleMarco di Antonio Nature Communications Published 13 December 2023 Crick labs/ facilitiesRickie PataniMarco Di AntonioHigh Throughput ScreeningFlow CytometryFull details Phenotypic profiling of solute carriers characterizes serine transport in cancer Authors (12)Vassilis Papalazarou Alice C Newman Alejandro Huerta-UribeNathalie Legrave Mattia Falcone Tong Zhang[...] Dimitris Athineos Emma Shanks Karen BlythKaren Vousden Oliver DK Maddocks Nature Metabolism Published 1 December 2023 Crick labs/ facilitiesKaren VousdenMetabolomicsLight MicroscopyHigh Throughput ScreeningFull details SARS-CoV-2 mucosal neutralising immunity after vaccination Authors (38)Edward Carr Guilia Dowgier David Greenwood Lou S Herman Agnieszka Hobbs Martina Ragno[...]Charles SwantonSonia GandhiDavid LV Bauer Emma WallMary Wu Lancet Infectious Diseases Published 1 January 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingFull details Stress granules plug and stabilize damaged endolysosomal membranes Authors (12)Claudio Bussi Agustín Mangiarotti Christian Vanhille-CamposBeren AylanEnrica PellegrinoNatalia Athanasiadi[...] Angela Rodgers Titus M Franzmann Anđela Šarić Rumiana DimovaMaximiliano Gutierrez Nature Published 30 November 2023 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyHuman Embryonic Stem CellHigh Throughput ScreeningFull details High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription Authors (10)Simon Butterworth Kristina Kordova Sambamurthy Chandrasekaran Kaitlin K ThomasFrancesca TorelliEloise LockyerAmelia EdwardsRobert Goldstone Anita A KoshyMoritz Treeck Cell Host and Microbe Published 11 October 2023 Crick labs/ facilitiesMoritz TreeckAdvanced SequencingHigh Throughput ScreeningFlow CytometryCell ServicesFull details PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection Authors (19)Daniel Fisch Moritz M Pfleiderer Eleni Anastasakou Gillian M Mackie Fabian Wendt Xiangyang Liu[...] Avinash R Shenoy Bernd Wollscheid Kendle M Maslowski Wojtek P Galej Eva-Maria Frickel Science Published 6 October 2023 Crick labs/ facilitiesEva FrickelProteomicsHigh Throughput ScreeningAdvanced SequencingFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia Authors (11)Fiona Grimm Agustín AsuajeAakriti JainMariana Silva Dos Santos Jens KleinjungPatricia Figueiredo Nunes Stefanie GehrigLouise Fets Salihanur DariciJames MacraeDimitrios Anastasiou The EMBO Journal Published 16 April 2024 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsBioinformatics and BiostatisticsLight MicroscopyHigh Throughput ScreeningAdvanced SequencingFull details
Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 23 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20)Eva Lana-ElolaRifdat Aoidi Miriam LlorianDorota GibbinsCallan BuechsenschuetzClaudio Bussi[...] Laurent MeijerBram SnijdersMaximiliano Gutierrez Elizabeth MC FisherVictor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilitiesVictor TybulewiczMaximiliano GutierrezProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes Authors (18) Benjamin B Johnson Marie-Victoire CossonLorenza Iolanda Tsansizi Terri L HolmesTegan Gilmore Katherine Hampton[...] John Whitelock Linda Troeberg Stuart A Rushworth Andreia S Bernardo James GW Smith Cell Reports Published 23 January 2024 Crick labs/ facilitiesJim SmithHigh Throughput ScreeningBioinformatics and BiostatisticsStructural BiologyMaking LabAdvanced SequencingFull details
The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes Authors (16) Federica RaguseoYiran Wang Jessica LiMarija Petric Howe Rubika Balendra Anouk Huyghebaert[...] Francesco A Aprile Yuval ElaniRickie Patani Lorenzo Di MicheleMarco di Antonio Nature Communications Published 13 December 2023 Crick labs/ facilitiesRickie PataniMarco Di AntonioHigh Throughput ScreeningFlow CytometryFull details
Phenotypic profiling of solute carriers characterizes serine transport in cancer Authors (12)Vassilis Papalazarou Alice C Newman Alejandro Huerta-UribeNathalie Legrave Mattia Falcone Tong Zhang[...] Dimitris Athineos Emma Shanks Karen BlythKaren Vousden Oliver DK Maddocks Nature Metabolism Published 1 December 2023 Crick labs/ facilitiesKaren VousdenMetabolomicsLight MicroscopyHigh Throughput ScreeningFull details
SARS-CoV-2 mucosal neutralising immunity after vaccination Authors (38)Edward Carr Guilia Dowgier David Greenwood Lou S Herman Agnieszka Hobbs Martina Ragno[...]Charles SwantonSonia GandhiDavid LV Bauer Emma WallMary Wu Lancet Infectious Diseases Published 1 January 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingFull details
Stress granules plug and stabilize damaged endolysosomal membranes Authors (12)Claudio Bussi Agustín Mangiarotti Christian Vanhille-CamposBeren AylanEnrica PellegrinoNatalia Athanasiadi[...] Angela Rodgers Titus M Franzmann Anđela Šarić Rumiana DimovaMaximiliano Gutierrez Nature Published 30 November 2023 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyHuman Embryonic Stem CellHigh Throughput ScreeningFull details
High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription Authors (10)Simon Butterworth Kristina Kordova Sambamurthy Chandrasekaran Kaitlin K ThomasFrancesca TorelliEloise LockyerAmelia EdwardsRobert Goldstone Anita A KoshyMoritz Treeck Cell Host and Microbe Published 11 October 2023 Crick labs/ facilitiesMoritz TreeckAdvanced SequencingHigh Throughput ScreeningFlow CytometryCell ServicesFull details
PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection Authors (19)Daniel Fisch Moritz M Pfleiderer Eleni Anastasakou Gillian M Mackie Fabian Wendt Xiangyang Liu[...] Avinash R Shenoy Bernd Wollscheid Kendle M Maslowski Wojtek P Galej Eva-Maria Frickel Science Published 6 October 2023 Crick labs/ facilitiesEva FrickelProteomicsHigh Throughput ScreeningAdvanced SequencingFull details
