Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb High Throughput Screening High Throughput Screening : Publications Lab contentLab contentIn this section Overview What we do Publications Members A plate handling robot (Access Robot; Labcyte) collecting a 384-well PCR plate from an automated centrifuge (background) to deliver it to an acoustic liquid handling device (the Echo550; Labcyte) Toggle to view hero caption Publications Displaying 21 - 30 of 140Last updated : 29 March 2024 03:46 GEN1 promotes common fragile site expression Authors (7)Anaid BenitezMarie SebaldKanagaraj RadhakrishnanMonica Rodrigo BrenniYing Wai ChanEric Chih-Chao LiangStephen West Cell Reports Published 28 February 2023 Crick labs/ facilitiesStephen WestLight MicroscopyHigh Throughput ScreeningFlow CytometryAdvanced SequencingFull details Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details Functional crosstalk between the cohesin loader and chromatin remodelers Authors (6)Sofia Munoz-FelixAndrew JonesCeline Bouchoux Tegan Gilmore Harshil PatelFrank Uhlmann Nature Communications Published 13 December 2022 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyHigh Throughput ScreeningFermentationFull details Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restriction Authors (10)Simon ButterworthFrancesca TorelliEloise LockyerJeanette WagenerOk-Ryul SongMalgorzata BroncelMatt Russell Aline Cristina A Moreira-SouzaJoanna YoungMoritz Treeck PLOS Pathogens Published 7 December 2022 Crick labs/ facilitiesMoritz TreeckProteomicsHigh Throughput ScreeningElectron MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress Authors (9)Michelle LehnerJane Walker Kotryna TemcinaiteAnna Herlihy Michael Taschner Adam C Berger Anita H Corbett A Barbara Dirac SvejstrupJesper Svejstrup Cell Reports Published 25 October 2022 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningFlow CytometryCell ServicesBioinformatics and BiostatisticsFull details WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed Authors (19)Mary WuEdward Carr Ruth HarveyHarriet MearsSvend Kjaer Hermaleigh Townsley[...] Bryan WilliamsSonia GandhiCharles Swanton Emma C WallDavid LV Bauer The Lancet Published 17 December 2022 Crick labs/ facilitiesCharles SwantonNicola LewisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: a nested case-control within the SIREN study Authors (37) Ana Atti Ferdinando InsalataEdward Carr Ashley D Otter Javier Castillo-OlivaresMary Wu[...] Susan Hopkins Tim Brooks Victoria Hall The SIREN Study Group The Crick COVID Immunity Pipeline Consortium Journal of Infection Published 1 November 2022 Crick labs/ facilitiesRupert BealeWorldwide Influenza CentreHigh Throughput ScreeningFull details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Authors (19)Jessica Nelson May Zaw ThinTheo Evan Steven HowellMary WuBruna Almeida[...]Bram Snijders Andreas Prachalias Yoh Zen Debashis SarkerAxel Behrens Nature Communications Published 19 April 2022 Crick labs/ facilitiesPeter RatcliffeAxel BehrensProteomicsMetabolomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Pagination First page First Previous page Previous Page 1 Page 2 Current page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
GEN1 promotes common fragile site expression Authors (7)Anaid BenitezMarie SebaldKanagaraj RadhakrishnanMonica Rodrigo BrenniYing Wai ChanEric Chih-Chao LiangStephen West Cell Reports Published 28 February 2023 Crick labs/ facilitiesStephen WestLight MicroscopyHigh Throughput ScreeningFlow CytometryAdvanced SequencingFull details
Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details
Functional crosstalk between the cohesin loader and chromatin remodelers Authors (6)Sofia Munoz-FelixAndrew JonesCeline Bouchoux Tegan Gilmore Harshil PatelFrank Uhlmann Nature Communications Published 13 December 2022 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyHigh Throughput ScreeningFermentationFull details
Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restriction Authors (10)Simon ButterworthFrancesca TorelliEloise LockyerJeanette WagenerOk-Ryul SongMalgorzata BroncelMatt Russell Aline Cristina A Moreira-SouzaJoanna YoungMoritz Treeck PLOS Pathogens Published 7 December 2022 Crick labs/ facilitiesMoritz TreeckProteomicsHigh Throughput ScreeningElectron MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress Authors (9)Michelle LehnerJane Walker Kotryna TemcinaiteAnna Herlihy Michael Taschner Adam C Berger Anita H Corbett A Barbara Dirac SvejstrupJesper Svejstrup Cell Reports Published 25 October 2022 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningFlow CytometryCell ServicesBioinformatics and BiostatisticsFull details
WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed Authors (19)Mary WuEdward Carr Ruth HarveyHarriet MearsSvend Kjaer Hermaleigh Townsley[...] Bryan WilliamsSonia GandhiCharles Swanton Emma C WallDavid LV Bauer The Lancet Published 17 December 2022 Crick labs/ facilitiesCharles SwantonNicola LewisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details
Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details
Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: a nested case-control within the SIREN study Authors (37) Ana Atti Ferdinando InsalataEdward Carr Ashley D Otter Javier Castillo-OlivaresMary Wu[...] Susan Hopkins Tim Brooks Victoria Hall The SIREN Study Group The Crick COVID Immunity Pipeline Consortium Journal of Infection Published 1 November 2022 Crick labs/ facilitiesRupert BealeWorldwide Influenza CentreHigh Throughput ScreeningFull details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Authors (19)Jessica Nelson May Zaw ThinTheo Evan Steven HowellMary WuBruna Almeida[...]Bram Snijders Andreas Prachalias Yoh Zen Debashis SarkerAxel Behrens Nature Communications Published 19 April 2022 Crick labs/ facilitiesPeter RatcliffeAxel BehrensProteomicsMetabolomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details