Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb High Throughput Screening High Throughput Screening : Publications Lab contentLab contentIn this section Overview What we do Publications Members A plate handling robot (Access Robot; Labcyte) collecting a 384-well PCR plate from an automated centrifuge (background) to deliver it to an acoustic liquid handling device (the Echo550; Labcyte) Toggle to view hero caption Publications Displaying 31 - 40 of 140Last updated : 24 April 2024 03:31 Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance Authors (19) Jason SL YuClara Correia-Melo Francisco Zorrilla Lucia Herrera-DominguezMary Wu Johannes Hartl[...]Michael Howell Judith Berman Kiran R Patil Mohammad Tauqeer AlamMarkus Ralser Nature Microbiology Published 1 April 2022 Crick labs/ facilitiesMarkus RalserHigh Throughput ScreeningFull details A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses Authors (7)Davide Coda Harshil PatelIlaria Gori Tessa E GaarenstroomOk-Ryul SongMichael HowellCaroline Hill Journal of Cell Science Published 15 April 2022 Crick labs/ facilitiesCaroline HillHigh Throughput ScreeningBioinformatics and BiostatisticsFlow CytometryCell ServicesAdvanced SequencingFull details Genome-protective topoisomerase 2a-dependent G2arrest requires p53 in hTERT-positive cancer cells Authors (12)Nicola LockwoodSilvia Martini Ainara Lopez-Pardo Katharina Deiss Hendrika A Segeren Robert K Semple[...]Dimitra RepanaMathias Cobbaut Tanya SolimanFrancesca CiccarelliPeter Parker Cancer Research Published 1 March 2022 Crick labs/ facilitiesPeter ParkerFrancesca CiccarelliLight MicroscopyHigh Throughput ScreeningFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19)Edward CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C WallEdward Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Functional profiling of long intergenic non-coding RNAs in fission yeast Authors (15) Maria Rodriguez-Lopez Shajahan Anver Cristina CotobalStephan Kamrad Michal MaleckiClara Correia-Melo[...]Mary Wu Luis MontemayorMichael HowellMarkus Ralser Jürg Bähler eLife Published 5 January 2022 Crick labs/ facilitiesMarkus RalserHigh Throughput ScreeningFull details Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Toxoplasma-proximal and distal control by GBPs in human macrophages Authors (5)Daniel FischBarbara Clough Rabia KhanLyn Healy Eva-Maria Frickel Pathogens and Disease Published 1 December 2021 Crick labs/ facilitiesEva FrickelHuman Embryonic Stem CellHigh Throughput ScreeningFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Pagination First page First Previous page Previous Page 1 Page 2 Page 3 Current page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance Authors (19) Jason SL YuClara Correia-Melo Francisco Zorrilla Lucia Herrera-DominguezMary Wu Johannes Hartl[...]Michael Howell Judith Berman Kiran R Patil Mohammad Tauqeer AlamMarkus Ralser Nature Microbiology Published 1 April 2022 Crick labs/ facilitiesMarkus RalserHigh Throughput ScreeningFull details
A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses Authors (7)Davide Coda Harshil PatelIlaria Gori Tessa E GaarenstroomOk-Ryul SongMichael HowellCaroline Hill Journal of Cell Science Published 15 April 2022 Crick labs/ facilitiesCaroline HillHigh Throughput ScreeningBioinformatics and BiostatisticsFlow CytometryCell ServicesAdvanced SequencingFull details
Genome-protective topoisomerase 2a-dependent G2arrest requires p53 in hTERT-positive cancer cells Authors (12)Nicola LockwoodSilvia Martini Ainara Lopez-Pardo Katharina Deiss Hendrika A Segeren Robert K Semple[...]Dimitra RepanaMathias Cobbaut Tanya SolimanFrancesca CiccarelliPeter Parker Cancer Research Published 1 March 2022 Crick labs/ facilitiesPeter ParkerFrancesca CiccarelliLight MicroscopyHigh Throughput ScreeningFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19)Edward CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C WallEdward Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Functional profiling of long intergenic non-coding RNAs in fission yeast Authors (15) Maria Rodriguez-Lopez Shajahan Anver Cristina CotobalStephan Kamrad Michal MaleckiClara Correia-Melo[...]Mary Wu Luis MontemayorMichael HowellMarkus Ralser Jürg Bähler eLife Published 5 January 2022 Crick labs/ facilitiesMarkus RalserHigh Throughput ScreeningFull details
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Toxoplasma-proximal and distal control by GBPs in human macrophages Authors (5)Daniel FischBarbara Clough Rabia KhanLyn Healy Eva-Maria Frickel Pathogens and Disease Published 1 December 2021 Crick labs/ facilitiesEva FrickelHuman Embryonic Stem CellHigh Throughput ScreeningFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
