Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb High Throughput Screening High Throughput Screening : Publications Lab contentLab contentIn this section Overview What we do Publications Members A plate handling robot (Access Robot; Labcyte) collecting a 384-well PCR plate from an automated centrifuge (background) to deliver it to an acoustic liquid handling device (the Echo550; Labcyte) Toggle to view hero caption Publications Displaying 41 - 50 of 140Last updated : 28 March 2024 02:20 Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients Authors (86)Edward Carr Mary Wu Ruth Harvey Emma C WallGavin KellySaira Hussain[...]Emma RussellAndy RiddellSvend KjaerAnnabel BorgChloe Roustan The Lancet Published 18 September 2021 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains Authors (30)Nikhil FaulknerKevin NgMary Wu Ruth Harvey Marios Margaritis Stavroula Paraskevopoulou[...]Michael HowellDavid LV Bauer Eleni Nastouli SAFER InvestigatorsGeorge Kassiotis eLife Published 29 July 2021 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease Authors (14)Berta Canal Ryo FujisawaAllison McClure Tom D DeeganMary WuRachel Ulferts[...]Jingkun ZengRupert BealeMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase Authors (12)Agostina BertolinFlorian WeissmannJingkun ZengViktor PosseJennifer MilliganBerta Canal[...]Mary WuLucy DruryMichael HowellRupert BealeJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease Authors (22)Jennifer MilliganTheresa ZeisnerGeorge PapageorgiouDhira JoshiChristelle SoudyRachel Ulferts[...]Michael HowellRupert Beale Karim LabibNicola O'ReillyJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Authors (19)Berta CanalAllison McClureJoseph CurranMary WuRachel UlfertsFlorian Weissmann[...]Clovis Basier Karim LabibRupert BealeMichael HowellJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningStructural BiologyFermentationFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease Authors (19)Chew Theng LimKang Wei TanMary WuRachel Ulferts Lee A ArmstrongEiko Ozono[...]Nicola O'ReillyRupert Beale Yogesh Kulathu Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase Authors (21)Saz BasuTiffany MakRachel UlfertsMary Wu Tom Deegan Ryo Fujisawa[...]Rupert Beale Victoria H CowlingMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Pagination First page First Previous page Previous Page 1 Page 2 Page 3 Page 4 Current page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients Authors (86)Edward Carr Mary Wu Ruth Harvey Emma C WallGavin KellySaira Hussain[...]Emma RussellAndy RiddellSvend KjaerAnnabel BorgChloe Roustan The Lancet Published 18 September 2021 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details
Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains Authors (30)Nikhil FaulknerKevin NgMary Wu Ruth Harvey Marios Margaritis Stavroula Paraskevopoulou[...]Michael HowellDavid LV Bauer Eleni Nastouli SAFER InvestigatorsGeorge Kassiotis eLife Published 29 July 2021 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease Authors (14)Berta Canal Ryo FujisawaAllison McClure Tom D DeeganMary WuRachel Ulferts[...]Jingkun ZengRupert BealeMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase Authors (12)Agostina BertolinFlorian WeissmannJingkun ZengViktor PosseJennifer MilliganBerta Canal[...]Mary WuLucy DruryMichael HowellRupert BealeJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease Authors (22)Jennifer MilliganTheresa ZeisnerGeorge PapageorgiouDhira JoshiChristelle SoudyRachel Ulferts[...]Michael HowellRupert Beale Karim LabibNicola O'ReillyJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Authors (19)Berta CanalAllison McClureJoseph CurranMary WuRachel UlfertsFlorian Weissmann[...]Clovis Basier Karim LabibRupert BealeMichael HowellJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningStructural BiologyFermentationFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease Authors (19)Chew Theng LimKang Wei TanMary WuRachel Ulferts Lee A ArmstrongEiko Ozono[...]Nicola O'ReillyRupert Beale Yogesh Kulathu Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase Authors (21)Saz BasuTiffany MakRachel UlfertsMary Wu Tom Deegan Ryo Fujisawa[...]Rupert Beale Victoria H CowlingMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details