Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb High Throughput Screening High Throughput Screening : Publications Lab contentLab contentIn this section Overview What we do Publications Members A plate handling robot (Access Robot; Labcyte) collecting a 384-well PCR plate from an automated centrifuge (background) to deliver it to an acoustic liquid handling device (the Echo550; Labcyte) Toggle to view hero caption Publications Displaying 71 - 80 of 140Last updated : 19 April 2024 03:55 GATA3 mediates a fast, irreversible commitment to BMP4-driven differentiation in human embryonic stem cells Authors (13)Alexandra Gunne-BradenAdrienne SullivanBorzo Gharibi Rahuman SM Sheriff Alok Maity Yi-Fang Wang[...]Michael HowellRobert Goldstone Roy WollmanPhil EastSilvia Santos Cell Stem Cell Published 7 May 2020 Crick labs/ facilitiesSilvia SantosHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingHuman Embryonic Stem CellFull details Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis Authors (17)Cristina Morales TorresMary WuSebastijan HoborElanor Wainwright Matthew J Martin Harshil Patel[...]Dominique Bonnet Paul D SmithCharles SwantonMichael HowellPaola Scaffidi Nature Communications Published 14 April 2020 Crick labs/ facilitiesCharles SwantonPaola ScaffidiDominique BonnetProteomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsBiological Research FacilityAdvanced SequencingFull details Regulation of the RNAPII pool is integral to the DNA damage response Authors (18) Ana Tufegdžić Vidaković Richard MitterGavin KellyMichelle Neumann Michelle HarremanMarta Rodriguez Martinez[...] Ronald C Conaway Joan W ConawayBram SnijdersAengus StewartJesper Svejstrup Cell Published 19 March 2020 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsHigh Throughput ScreeningCell ServicesAdvanced SequencingFull details IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche Authors (17) Sissy E Wamaitha Katarzyna J GrybelGregorio Alanis LobatoClaudia GerriSugako OgushiAfshan Mccarthy[...] Phil Snell Leila ChristieJulian DownwardJames TurnerKathy Niakan Nature Communications Published 7 February 2020 Crick labs/ facilitiesJames TurnerKathy NiakanJulian DownwardHuman Embryonic Stem CellScientific computingLight MicroscopyHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsFull details Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist Authors (7)Kevin NgJan AttigGeorge YoungEleonora Ottina Spyros I Papamichos Ioannis KotsianidisGeorge Kassiotis eLife Published 15 November 2019 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisScientific computingLight MicroscopyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii Authors (10)Alexander HuntMatt RussellJeanette Wagener Robyn Kent Romain CarmeilleChris PeddieLucy Collinson Aoife Heaslip Gary E WardMoritz Treeck eLife Published 2 October 2019 Crick labs/ facilitiesMoritz TreeckElectron MicroscopyLight MicroscopyHigh Throughput ScreeningFlow CytometryCell ServicesFull details Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability Authors (11) Diana Zatreanu Zhong Han Richard Mitter Emanuela Tumini Hannah WilliamsLea GregersenBarbara Dirac-Svejstrup Stefania RomaAengus Stewart Andres AguileraJesper Svejstrup Molecular Cell Published 3 October 2019 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsHigh Throughput ScreeningAdvanced SequencingFull details A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice Authors (12)Joanna YoungCaia DominicusJeanette WagenerSimon Butterworth Xingda YeGavin Kelly[...] Becky SaundersRachael InstrellMichael HowellAengus Stewart Moritz Treeck Nature Communications Published 3 September 2019 Crick labs/ facilitiesMoritz TreeckHigh Throughput ScreeningBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma Authors (14) Thanos P MourikisLorena Benedetti Elizabeth FoxallDamjan TemelkovskiJoel Nulsen Juliane Perner[...] Christopher Yau Rebecca C FitzgeraldPaola Scaffidi Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) ConsortiumFrancesca Ciccarelli Nature Communications Published 15 July 2019 Crick labs/ facilitiesPaola ScaffidiFrancesca CiccarelliHigh Throughput ScreeningFlow CytometryCell ServicesAdvanced SequencingFull details RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability Authors (4)Jessica DiringStephane MouilleronNeil McDonaldRichard Treisman Nature Cell Biology Published 1 July 2019 Crick labs/ facilitiesRichard TreismanNeil McDonaldStructural BiologyLight MicroscopyHigh Throughput ScreeningFlow CytometryFermentationBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details Pagination First page First Previous page Previous … Page 4 Page 5 Page 6 Page 7 Current page 8 Page 9 Page 10 Page 11 Page 12 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
GATA3 mediates a fast, irreversible commitment to BMP4-driven differentiation in human embryonic stem cells Authors (13)Alexandra Gunne-BradenAdrienne SullivanBorzo Gharibi Rahuman SM Sheriff Alok Maity Yi-Fang Wang[...]Michael HowellRobert Goldstone Roy WollmanPhil EastSilvia Santos Cell Stem Cell Published 7 May 2020 Crick labs/ facilitiesSilvia SantosHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingHuman Embryonic Stem CellFull details
Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis Authors (17)Cristina Morales TorresMary WuSebastijan HoborElanor Wainwright Matthew J Martin Harshil Patel[...]Dominique Bonnet Paul D SmithCharles SwantonMichael HowellPaola Scaffidi Nature Communications Published 14 April 2020 Crick labs/ facilitiesCharles SwantonPaola ScaffidiDominique BonnetProteomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsBiological Research FacilityAdvanced SequencingFull details
Regulation of the RNAPII pool is integral to the DNA damage response Authors (18) Ana Tufegdžić Vidaković Richard MitterGavin KellyMichelle Neumann Michelle HarremanMarta Rodriguez Martinez[...] Ronald C Conaway Joan W ConawayBram SnijdersAengus StewartJesper Svejstrup Cell Published 19 March 2020 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsHigh Throughput ScreeningCell ServicesAdvanced SequencingFull details
IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche Authors (17) Sissy E Wamaitha Katarzyna J GrybelGregorio Alanis LobatoClaudia GerriSugako OgushiAfshan Mccarthy[...] Phil Snell Leila ChristieJulian DownwardJames TurnerKathy Niakan Nature Communications Published 7 February 2020 Crick labs/ facilitiesJames TurnerKathy NiakanJulian DownwardHuman Embryonic Stem CellScientific computingLight MicroscopyHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsFull details
Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist Authors (7)Kevin NgJan AttigGeorge YoungEleonora Ottina Spyros I Papamichos Ioannis KotsianidisGeorge Kassiotis eLife Published 15 November 2019 Crick labs/ facilitiesJonathan StoyeGeorge KassiotisScientific computingLight MicroscopyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii Authors (10)Alexander HuntMatt RussellJeanette Wagener Robyn Kent Romain CarmeilleChris PeddieLucy Collinson Aoife Heaslip Gary E WardMoritz Treeck eLife Published 2 October 2019 Crick labs/ facilitiesMoritz TreeckElectron MicroscopyLight MicroscopyHigh Throughput ScreeningFlow CytometryCell ServicesFull details
Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability Authors (11) Diana Zatreanu Zhong Han Richard Mitter Emanuela Tumini Hannah WilliamsLea GregersenBarbara Dirac-Svejstrup Stefania RomaAengus Stewart Andres AguileraJesper Svejstrup Molecular Cell Published 3 October 2019 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsHigh Throughput ScreeningAdvanced SequencingFull details
A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice Authors (12)Joanna YoungCaia DominicusJeanette WagenerSimon Butterworth Xingda YeGavin Kelly[...] Becky SaundersRachael InstrellMichael HowellAengus Stewart Moritz Treeck Nature Communications Published 3 September 2019 Crick labs/ facilitiesMoritz TreeckHigh Throughput ScreeningBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details
Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma Authors (14) Thanos P MourikisLorena Benedetti Elizabeth FoxallDamjan TemelkovskiJoel Nulsen Juliane Perner[...] Christopher Yau Rebecca C FitzgeraldPaola Scaffidi Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) ConsortiumFrancesca Ciccarelli Nature Communications Published 15 July 2019 Crick labs/ facilitiesPaola ScaffidiFrancesca CiccarelliHigh Throughput ScreeningFlow CytometryCell ServicesAdvanced SequencingFull details
RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability Authors (4)Jessica DiringStephane MouilleronNeil McDonaldRichard Treisman Nature Cell Biology Published 1 July 2019 Crick labs/ facilitiesRichard TreismanNeil McDonaldStructural BiologyLight MicroscopyHigh Throughput ScreeningFlow CytometryFermentationBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
