Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Making Lab Making Lab : Publications Lab contentLab contentIn this section Overview Equipment Methodologies Publications Members A microfluidic device (aka 'miniature plumbing') used to regulate fluid dynamics at the scale of individual cells. This image was captured by Ravi Desai. Toggle to view hero caption PublicationsResearch topicsCell Biology (4)Computational & Systems Biology (4)Imaging (4)Microfabrication & Bioengineering (4)Structural Biology & Biophysics (4)Biochemistry & Proteomics (2)Chemical Biology & High Throughput (2)Developmental Biology (2)Metabolism (2)Neurosciences (2)Cell Cycle & Chromosomes (1)Genome Integrity & Repair (1)Human Biology & Physiology (1)Immunology (1)Infectious Disease (1)Signalling & Oncogenes (1)Stem Cells (1)Tumour Biology (1) Facet Research topicsJournalDevelopmental Cell (2)Nature Communications (2)Bioengineering & Translational Medicine (1)Biomedical Optics Express (1)FEBS Journal (1)Journal of Neural Engineering (1)Nature Cell Biology (1)PLOS ONE (1)Proceedings of the National Academy of Sciences of the United States of America (1) Facet JournalYear published2022 (2)2021 (1)2020 (2)2019 (1)2017 (4)2015 (1) Facet Year published Publications Displaying 1 - 10 of 11Last updated : 28 March 2023 03:47 Integrated role of human thymic stromal cells in hematopoietic stem cell extravasation Authors (7)Sara Watson Yousef JavanmardiLuca Zanieri Somayeh ShahrezaRoberta RagazziniPaola Bonfanti Emad Moeendarbary Bioengineering & Translational Medicine Published 1 March 2023 Crick labs/ facilitiesPaola BonfantiMaking LabLight MicroscopyFull details jULIEs: nanostructured polytrodes for low traumatic extracellular recordings and stimulation in the mammalian brain Authors (13)Romeo RaczMihaly Kollo Gabriella Racz Ciprian BulzTobias AckelsTom Warner[...] Chi ChenZhiwen Ye Livia de HozEde RanczAndreas Schaefer Journal of Neural Engineering Published 28 February 2022 Crick labs/ facilitiesAndreas SchaeferEde RanczMaking LabTranslation teamElectron MicroscopyBiological Research FacilityFull details Dual-view light-sheet imaging through a tilted glass interface using a deformable mirror Authors (7) Nikita Vladimirov Friedrich Preusser Jan Wisniewski Ziv YanivRavi Desai Andrew Woehler Stephan Preibisch Biomedical Optics Express Published 1 April 2021 Crick labs/ facilitiesMaking LabFull details Microfluidic flow-cell with passive flow control for microscopy applications Authors (2)Nicholas BellJustin Molloy PLOS ONE Published 15 December 2020 Crick labs/ facilitiesJustin MolloyMaking LabFull details Modular microfluidics enables kinetic insight from time-resolved cryo-EM Authors (11)Erik Maeots Byungjin LeeAndrea Nans Seung-Geun JeongNasr Nasr EsfahaniShan Ding Daniel J Smith Chang-Soo Lee Sung Sik Lee Matthias PeterRadoslav Enchev Nature Communications Published 10 July 2020 Crick labs/ facilitiesRadoslav EnchevStructural BiologyMaking LabLight MicroscopyFull details Cellular geometry scaling ensures robust division site positioning Authors (2)Ying GuSnezhka Oliferenko Nature Communications Published 21 January 2019 Crick labs/ facilitiesSnezhana OliferenkoMaking LabFull details Myosin II controls junction fluctuations to guide epithelial tissue ordering Authors (7)Scott Curran Charlotte Strandkvist Jasper BathmannMarc De Gennes Alexandre KablaGuillaume Salbreux Buzz Baum Developmental Cell Published 20 November 2017 Crick labs/ facilitiesGuillaume SalbreuxMaking LabFull details An engineered photoswitchable mammalian pyruvate kinase Authors (9) Stefanie GehrigJames MacphersonPaul Driscoll Alastair Symon Stephen R MartinJames Macrae Jens Kleinjung Franca FraternaliDimitrios Anastasiou FEBS Journal Published 1 September 2017 Crick labs/ facilitiesDimitrios AnastasiouStructural BiologyMetabolomicsMaking LabBioinformatics and BiostatisticsMRC Biomedical NMR CentreFull details Orexin-driven GAD65 network of the lateral hypothalamus sets physical activity in mice Authors (4) Christin Kosse Cornelia Schöne Edward Bracey Denis Burdakov Proceedings of the National Academy of Sciences of the United States of America Published 25 April 2017 Crick labs/ facilitiesDenis BurdakovMaking LabFull details Cell-cell contact area affects notch signaling and notch-dependent patterning Authors (13) O Shaya U Binshtok M Hersch D Rivkin S Weinreb L Amir-Zilberstein[...]Ravi Desai RJ Goodyear GP Richardson CS Chen D Sprinzak Developmental Cell Published 13 March 2017 Crick labs/ facilitiesMaking LabFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Integrated role of human thymic stromal cells in hematopoietic stem cell extravasation Authors (7)Sara Watson Yousef JavanmardiLuca Zanieri Somayeh ShahrezaRoberta RagazziniPaola Bonfanti Emad Moeendarbary Bioengineering & Translational Medicine Published 1 March 2023 Crick labs/ facilitiesPaola BonfantiMaking LabLight MicroscopyFull details
jULIEs: nanostructured polytrodes for low traumatic extracellular recordings and stimulation in the mammalian brain Authors (13)Romeo RaczMihaly Kollo Gabriella Racz Ciprian BulzTobias AckelsTom Warner[...] Chi ChenZhiwen Ye Livia de HozEde RanczAndreas Schaefer Journal of Neural Engineering Published 28 February 2022 Crick labs/ facilitiesAndreas SchaeferEde RanczMaking LabTranslation teamElectron MicroscopyBiological Research FacilityFull details
Dual-view light-sheet imaging through a tilted glass interface using a deformable mirror Authors (7) Nikita Vladimirov Friedrich Preusser Jan Wisniewski Ziv YanivRavi Desai Andrew Woehler Stephan Preibisch Biomedical Optics Express Published 1 April 2021 Crick labs/ facilitiesMaking LabFull details
Microfluidic flow-cell with passive flow control for microscopy applications Authors (2)Nicholas BellJustin Molloy PLOS ONE Published 15 December 2020 Crick labs/ facilitiesJustin MolloyMaking LabFull details
Modular microfluidics enables kinetic insight from time-resolved cryo-EM Authors (11)Erik Maeots Byungjin LeeAndrea Nans Seung-Geun JeongNasr Nasr EsfahaniShan Ding Daniel J Smith Chang-Soo Lee Sung Sik Lee Matthias PeterRadoslav Enchev Nature Communications Published 10 July 2020 Crick labs/ facilitiesRadoslav EnchevStructural BiologyMaking LabLight MicroscopyFull details
Cellular geometry scaling ensures robust division site positioning Authors (2)Ying GuSnezhka Oliferenko Nature Communications Published 21 January 2019 Crick labs/ facilitiesSnezhana OliferenkoMaking LabFull details
Myosin II controls junction fluctuations to guide epithelial tissue ordering Authors (7)Scott Curran Charlotte Strandkvist Jasper BathmannMarc De Gennes Alexandre KablaGuillaume Salbreux Buzz Baum Developmental Cell Published 20 November 2017 Crick labs/ facilitiesGuillaume SalbreuxMaking LabFull details
An engineered photoswitchable mammalian pyruvate kinase Authors (9) Stefanie GehrigJames MacphersonPaul Driscoll Alastair Symon Stephen R MartinJames Macrae Jens Kleinjung Franca FraternaliDimitrios Anastasiou FEBS Journal Published 1 September 2017 Crick labs/ facilitiesDimitrios AnastasiouStructural BiologyMetabolomicsMaking LabBioinformatics and BiostatisticsMRC Biomedical NMR CentreFull details
Orexin-driven GAD65 network of the lateral hypothalamus sets physical activity in mice Authors (4) Christin Kosse Cornelia Schöne Edward Bracey Denis Burdakov Proceedings of the National Academy of Sciences of the United States of America Published 25 April 2017 Crick labs/ facilitiesDenis BurdakovMaking LabFull details
Cell-cell contact area affects notch signaling and notch-dependent patterning Authors (13) O Shaya U Binshtok M Hersch D Rivkin S Weinreb L Amir-Zilberstein[...]Ravi Desai RJ Goodyear GP Richardson CS Chen D Sprinzak Developmental Cell Published 13 March 2017 Crick labs/ facilitiesMaking LabFull details
