Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Proteomics Proteomics : Publications Lab contentLab contentIn this section Overview Publications Members The Mass Spectrometry Proteomics STP. Toggle to view hero caption Publications Displaying 31 - 40 of 236Last updated : 18 April 2024 02:48 Bump-and-hole engineering of human polypeptide N-acetylgalactosamine transferases to dissect their protein substrates and glycosylation sites in cells Authors (10)Bea CalleEdgar Gonzalez-Rodriguez Keira E MahoneyAnna CioceGanka Bineva-ToddOmur Yilmaz TastanChloe Roustan Helen Flynn Stacy A MalakerBen Schumann STAR Protocols Published 17 March 2023 Crick labs/ facilitiesBen SchumannStructural BiologyProteomicsFull details Functional crosstalk between the cohesin loader and chromatin remodelers Authors (6)Sofia Munoz-FelixAndrew JonesCeline Bouchoux Tegan Gilmore Harshil PatelFrank Uhlmann Nature Communications Published 13 December 2022 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyHigh Throughput ScreeningFermentationFull details Elongation factor-specific capture of RNA polymerase II complexes Authors (3) Lea H Gregersen Richard MitterJesper Svejstrup Cell Reports Methods Published 19 December 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsAdvanced SequencingFull details Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restriction Authors (10)Simon ButterworthFrancesca TorelliEloise LockyerJeanette WagenerOk-Ryul SongMalgorzata BroncelMatt Russell Aline Cristina A Moreira-SouzaJoanna YoungMoritz Treeck PLOS Pathogens Published 7 December 2022 Crick labs/ facilitiesMoritz TreeckProteomicsHigh Throughput ScreeningElectron MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration Authors (14) Flavia RoşianuSimeon MihaylovNoreen Eder Antonie MartiniucSuzanne Claxton Helen R Flynn[...]Mark SkehelBram Snijders Matthias KrauseSharon ToozeSila Ultanir Life Science Alliance Published 1 February 2023 Crick labs/ facilitiesSila UltanirSharon ToozeProteomicsElectron MicroscopyExperimental HistopathologyFull details N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast Authors (18) Radhika A VarierTheodora SideriCharlotte CapitanchikZornitsa ManovaEnrica CalvaniAlice Rossi[...] Michiel VermeulenMarkus RalserJernej UleNicholas LuscombeFolkert Van Werven eLife Published 24 November 2022 Crick labs/ facilitiesFolkert van WervenJernej UleMarkus RalserNicholas LuscombeProteomicsMetabolomicsBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation Authors (15)Alexander Van VlietGeorge Chiduza Sarah L MaslenVal PyeDhira JoshiStefano De Tito[...]Javier HervasNicola O'ReillyMark SkehelPeter CherepanovSharon Tooze Molecular Cell Published 17 November 2022 Crick labs/ facilitiesSharon ToozePeter Cherepanov Structural BiologyProteomicsLight MicroscopyElectron MicroscopyFull details Cell-specific bioorthogonal tagging of glycoproteins Authors (31)Anna CioceBea CalleTatiana Rizou Sarah C LoweryVicky Bridgeman Keira E Mahoney[...] Stuart M Haslam Sabine L Flitsch Stacy A MalakerIlaria MalanchiBen Schumann Nature Communications Published 25 October 2022 Crick labs/ facilitiesJernej UleBen SchumannIlaria MalanchiLuiz Pedro CarvalhoStructural BiologyProteomicsBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress Authors (9)Michelle LehnerJane Walker Kotryna TemcinaiteAnna Herlihy Michael Taschner Adam C Berger Anita H Corbett A Barbara Dirac SvejstrupJesper Svejstrup Cell Reports Published 25 October 2022 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningFlow CytometryCell ServicesBioinformatics and BiostatisticsFull details A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in calcium-induced Toxoplasma gondii egress Authors (9)Stephanie NofalCaia DominicusMalgorzata Broncel Nicholas J Katris Helen R Flynn Gustavo Arrizabalaga Cyrille Y Botté Brandon M InvergoMoritz Treeck PLOS Pathogens Published 20 October 2022 Crick labs/ facilitiesMoritz TreeckProteomicsFull details Pagination First page First Previous page Previous Page 1 Page 2 Page 3 Current page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Bump-and-hole engineering of human polypeptide N-acetylgalactosamine transferases to dissect their protein substrates and glycosylation sites in cells Authors (10)Bea CalleEdgar Gonzalez-Rodriguez Keira E MahoneyAnna CioceGanka Bineva-ToddOmur Yilmaz TastanChloe Roustan Helen Flynn Stacy A MalakerBen Schumann STAR Protocols Published 17 March 2023 Crick labs/ facilitiesBen SchumannStructural BiologyProteomicsFull details
Functional crosstalk between the cohesin loader and chromatin remodelers Authors (6)Sofia Munoz-FelixAndrew JonesCeline Bouchoux Tegan Gilmore Harshil PatelFrank Uhlmann Nature Communications Published 13 December 2022 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyHigh Throughput ScreeningFermentationFull details
Elongation factor-specific capture of RNA polymerase II complexes Authors (3) Lea H Gregersen Richard MitterJesper Svejstrup Cell Reports Methods Published 19 December 2022 Crick labs/ facilitiesJesper SvejstrupBioinformatics and BiostatisticsProteomicsAdvanced SequencingFull details
Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restriction Authors (10)Simon ButterworthFrancesca TorelliEloise LockyerJeanette WagenerOk-Ryul SongMalgorzata BroncelMatt Russell Aline Cristina A Moreira-SouzaJoanna YoungMoritz Treeck PLOS Pathogens Published 7 December 2022 Crick labs/ facilitiesMoritz TreeckProteomicsHigh Throughput ScreeningElectron MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration Authors (14) Flavia RoşianuSimeon MihaylovNoreen Eder Antonie MartiniucSuzanne Claxton Helen R Flynn[...]Mark SkehelBram Snijders Matthias KrauseSharon ToozeSila Ultanir Life Science Alliance Published 1 February 2023 Crick labs/ facilitiesSila UltanirSharon ToozeProteomicsElectron MicroscopyExperimental HistopathologyFull details
N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast Authors (18) Radhika A VarierTheodora SideriCharlotte CapitanchikZornitsa ManovaEnrica CalvaniAlice Rossi[...] Michiel VermeulenMarkus RalserJernej UleNicholas LuscombeFolkert Van Werven eLife Published 24 November 2022 Crick labs/ facilitiesFolkert van WervenJernej UleMarkus RalserNicholas LuscombeProteomicsMetabolomicsBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details
ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation Authors (15)Alexander Van VlietGeorge Chiduza Sarah L MaslenVal PyeDhira JoshiStefano De Tito[...]Javier HervasNicola O'ReillyMark SkehelPeter CherepanovSharon Tooze Molecular Cell Published 17 November 2022 Crick labs/ facilitiesSharon ToozePeter Cherepanov Structural BiologyProteomicsLight MicroscopyElectron MicroscopyFull details
Cell-specific bioorthogonal tagging of glycoproteins Authors (31)Anna CioceBea CalleTatiana Rizou Sarah C LoweryVicky Bridgeman Keira E Mahoney[...] Stuart M Haslam Sabine L Flitsch Stacy A MalakerIlaria MalanchiBen Schumann Nature Communications Published 25 October 2022 Crick labs/ facilitiesJernej UleBen SchumannIlaria MalanchiLuiz Pedro CarvalhoStructural BiologyProteomicsBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress Authors (9)Michelle LehnerJane Walker Kotryna TemcinaiteAnna Herlihy Michael Taschner Adam C Berger Anita H Corbett A Barbara Dirac SvejstrupJesper Svejstrup Cell Reports Published 25 October 2022 Crick labs/ facilitiesJesper SvejstrupProteomicsHigh Throughput ScreeningFlow CytometryCell ServicesBioinformatics and BiostatisticsFull details
A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in calcium-induced Toxoplasma gondii egress Authors (9)Stephanie NofalCaia DominicusMalgorzata Broncel Nicholas J Katris Helen R Flynn Gustavo Arrizabalaga Cyrille Y Botté Brandon M InvergoMoritz Treeck PLOS Pathogens Published 20 October 2022 Crick labs/ facilitiesMoritz TreeckProteomicsFull details